Serum lipoprotein subfractions are associated with the periodontal status: Results from the population‐based cohort SHIP‐TREND DOI Creative Commons
M Kapp, Birte Holtfreter, Thomas Kocher

et al.

Journal Of Clinical Periodontology, Journal Year: 2023, Volume and Issue: 51(4), P. 390 - 405

Published: Dec. 14, 2023

Abstract Aim To investigate the medium‐term associations of serum protein subfractions derived from proton nuclear magnetic resonance ( 1 H‐NMR) spectroscopy with periodontitis and tooth loss. Materials Methods A total 3031 participants cohort Study Health in Pomerania (SHIP‐TREND) were included. In addition to conventional testing, lipoprotein contents analysed by H‐NMR spectroscopy. Confounder‐adjusted variables number missing teeth using mixed‐effects models random intercepts for time across individuals, accounting multiple testing. Results While only spurious between levels blood tests found—that is, triglycerides associated mean clinical attachment level (CAL) low‐density cholesterol/high‐density cholesterol (LDL‐C/HDL‐C) ratio ‐ several emerged analysis. Specifically, elevated LDL higher probing depth (PD), CALs, increased odds having <20 teeth. HDL‐4 inversely PD. Systemic inflammation (C‐reactive protein) might mediate effects HDL triglyceride on severity. Conclusions Several observed. As underlying biochemical mechanisms remain unclear, further research is needed.

Language: Английский

The association between triglyceride-glucose index and the likelihood of cardiovascular disease in the U.S. population of older adults aged ≥ 60 years: a population-based study DOI Creative Commons
Dan Liang, Chang Liu, Yan Wang

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 3, 2024

Abstract Background The association between the triglyceride-glucose (TyG) index and likelihood of developing cardiovascular disease (CVD) in general elderly population United States aged 60 above is not well understood. objective our study was to examine relationship TyG CVD over years age States. Methods Data for this cross-sectional were sourced from 2003–2018 National Health Nutrition Examination Survey. Weighted multivariable regression analysis subgroup conducted estimate independent CVD. Non-linear correlations explored using restricted cubic splines. Results A total 6502 participants included, with a mean 8.75 ± 0.01. average prevalence 24.31% overall. Participants higher quartiles showed high rates (Quartile 1: 19.91%; Quartile 2: 21.65%; 3: 23.82%; 4: 32.43%). For CVD, possible odds observed. Our findings suggest nonlinear threshold 8.73 Interaction terms employed assess heterogeneities among each subgroup, revealing significant difference specifically alcohol consumption. This suggests that positive dependent on drinking status participants. Conclusion linked an increased US adults ≥ years. anticipated emerge as more effective metric identifying populations at early

Language: Английский

Citations

18
Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults DOI Creative Commons
Lisha Lin,

Jenna Kiryakos,

Farah Ammous

et al.

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 27, 2024

Abstract Background Dyslipidemia, which is characterized by an unfavorable lipid profile, a key risk factor for cardiovascular disease (CVD). Understanding the relationships between epigenetic aging and levels may help guide early prevention treatment efforts dyslipidemia. Methods We used weighted linear regression to cross-sectionally investigate associations five measures of age acceleration estimated from whole blood DNA methylation (HorvathAge Acceleration, HannumAge PhenoAge GrimAge DunedinPACE) four (total cholesterol (TC), LDL-C, HDL-C, triglycerides (TG)) in 3,813 participants (mean = 70 years) Health Retirement Study (HRS). As sensitivity analysis, we examined same who fasted prior draw ( n 2,531) did not take lipid-lowering medication 1,869). Using interaction models, also whether demographic factors including age, sex, educational attainment modified lipids. Results After adjusting race/ethnicity, fasting status, use, greater was associated with lower TC, higher TG p < 0.05), although effect sizes were relatively small (e.g., 7 mg/dL TC per standard deviation acceleration). DunedinPACE all lipids remained significant after further adjustment body mass index, smoking attainment. These stronger use medication, particularly LDL-C. observed largest number interactions factors, where younger participants, females, those Conclusion Multiple are older adults. A understanding how these differ across groups can shed light on downstream diseases. The inverse LDL-C could be due sample limitations or non-linear lipids, as both decrease faster at ages.

Language: Английский

Citations

5
Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults DOI
Minkyung Lee, Kyungdo Han,

Bongsung Kim

et al.

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 208, P. 111109 - 111109

Published: Jan. 21, 2024

Language: Английский

Citations

4
Trends and Prevalence of Severe Hypertriglyceridemia in Pakistan: A Five-Year Analysis (2019-2023) DOI

Quratul Ain,

Madeeha Khan, Amjad Nawaz

et al.

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults DOI Creative Commons
Lisha Lin,

Jenna Kiryakos,

Farah Ammous

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 27, 2024

Abstract Background Dyslipidemia, which is characterized by an unfavorable lipid profile, a key risk factor for cardiovascular disease (CVD). Understanding the relationships between epigenetic aging and levels may help guide early prevention treatment efforts dyslipidemia. Methods We used weighted linear regression to cross-sectionally investigate associations five measures of age acceleration estimated from whole blood DNA methylation (HorvathAge Acceleration, HannumAge PhenoAge GrimAge DunedinPACE) four (total cholesterol (TC), LDL-C, HDL-C, triglycerides (TG)) in 3,813 participants (mean = 70 years) Health Retirement Study (HRS). As sensitivity analysis, we examined same who fasted prior draw (n 2,531) did not take lipid-lowering medication 1,869). Using interaction models, also whether lipids differ demographic factors including age, sex, educational attainment. Results After adjusting race/ethnicity, fasting status, use, greater was associated with lower TC, higher TG (p < 0.05). DunedinPACE all remained significant after further body mass index, smoking These were stronger use medication, particularly LDL-C. observed largest number interactions factors, where younger participants, females, those Conclusion Epigenetic acceleration, powerful biomarker cellular aging, highly older adults. A understanding how these across groups can shed light on downstream diseases. The inverse TC LDL-C could be due sample limitations or non-linear relationship lipids, as both decrease faster at ages. More studies are needed understand temporal other health outcomes.

Language: Английский

Citations

2
Income-Related Disparities in Mortality Among Young Adults With Type 2 Diabetes DOI Creative Commons
Ji Yoon Kim, Sojeong Park, Minae Park

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(11), P. e2443918 - e2443918

Published: Nov. 12, 2024

Previous studies have indicated an inverse association between income and mortality. However, differences in health outcomes according to the level of young adults with type 2 diabetes (T2D) compared older T2D not been elucidated.

Language: Английский

Citations

2
Letter by In-Kyung Jeong Regarding Article, Trends in Prevalence of Hypertriglyceridemia and Related Factors in Korean Adults: A Serial Cross-Sectional Study DOI Creative Commons
In‐Kyung Jeong

Journal of Lipid and Atherosclerosis, Journal Year: 2024, Volume and Issue: 13(1), P. 80 - 80

Published: Jan. 1, 2024

Language: Английский

Citations

1
Functional Impact of the FADS1 rs174546 Single Nucleotide Polymorphism on Serum Lipid Levels: Insights from Molecular Mechanisms and Therapeutic Perspectives in Korean Population DOI Creative Commons
Kyun‐Hee Lee,

Soon‐Hee Kim,

Sunmin Park

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(15)

Published: July 3, 2024

Single nucleotide polymorphisms (SNP) in the fatty acid desaturase 1 (FADS1) gene is suggested as risk factor of metabolic diseases genome-wide association studies (GWAS). This study hypothesized that FADS1_rs174546T associates with serum triglycerides (TG) Korean Genome and Epidemiology Study (KoGES). In addition, functional SNP genotypes cultured cells performed.

Language: Английский

Citations

1
Human like severe hypertriglyceridemia in a high fat fed chicken model DOI Creative Commons

K Saranya,

JG Beniha,

TK Deepshikha

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 22, 2024

Summary Cardiovascular disease (CVD) is the biggest cause of mortality globally. Controlling risk factors for CVD such as blood cholesterol and triglycerides hallmark primary prevention CVD. There are several drugs to control that available but not many approaches reducing safely available. High or hypertriglyceridemia in humans classified moderate (200-400 mg/dl plasma levels) severe (400-800 mg/dl) very (>800 mg/dl). appropriate vivo models study human like hypertriglyceridemia. We show here high fat fed chickens rapidly a sustained manner respond by demonstrating triglyceride levels reminiscent humans. Such model could be useful better understanding this well serve test new therapies.

Language: Английский

Citations

1
2024 KSoLA consensus on secondary dyslipidemia DOI Creative Commons
Hoyoun Won, Jae Hyun Bae, Hyunjung Lim

et al.

The Korean Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 39(5), P. 717 - 730

Published: Aug. 30, 2024

Elevated blood cholesterol and triglyceride levels induced by secondary causes are frequently observed. The identification appropriate handling of these essential for dyslipidemia treatment. Major hypercholesterolemia hypertriglyceridemia include an unhealthy diet, diseases metabolic conditions affecting lipid levels, therapeutic side effects. It is imperative to correct prior initiating conventional lipid-lowering therapy. Guideline-based therapy can then be administered based on the subsequent levels.

Language: Английский

Citations

1