Journal of Infectious Diseases and Epidemiology,
Journal Year:
2021,
Volume and Issue:
7(4)
Published: April 30, 2021
Coronavirus
infectious
disease
2019
(COVID-19)
pandemic
is
a
global
public
health
issue
due
to
new
coronavirus
called
severe
acute
respiratory
syndrome
virus
2
(SARS-Cov-2).
It
very
contagious
with
often
benign
symptoms.
However,
some
patients
present
clinical
signs
and
are
more
at
risk
die.
The
aim
of
this
study
was
assess
the
factors
associated
COVID-19
in
an
Epidemic
Treatment
Center
(ETC)
Dakar,
Senegal.
Tuberculosis & respiratory diseases,
Journal Year:
2024,
Volume and Issue:
87(2), P. 145 - 154
Published: Feb. 18, 2024
The
consequences
of
coronavirus
disease
2019
(COVID-19)
are
particularly
severe
in
older
adults
with
a
disproportionate
number
and
fatal
outcomes.
Therefore,
this
integrative
review
aimed
to
provide
comprehensive
overview
the
clinical
characteristics,
management
approaches,
prognosis
patients
diagnosed
COVID-19.
Common
presentations
include
fever,
cough,
dyspnea.
Additionally,
preexisting
comorbidities,
especially
diabetes
pulmonary
cardiovascular
diseases,
were
frequently
observed
associated
adverse
Management
strategies
varied,
however,
early
diagnosis,
vigilant
monitoring,
multidisciplinary
care
identified
as
key
factors
for
enhancing
patient
Nonetheless,
remains
guarded
patients,
increased
rates
hospitalization,
mechanical
ventilation,
mortality.
However,
timely
therapeutic
interventions,
antiviral
supportive
treatments,
have
demonstrated
some
efficacy
mitigating
age
group.
In
conclusion,
while
remain
highly
susceptible
outcomes
from
COVID-19,
intervention,
rigorous
can
play
pivotal
role
improving
their
Journal of Neuroinflammation,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Aug. 28, 2024
Trauma
can
result
in
systemic
inflammation
that
leads
to
organ
dysfunction,
but
the
impact
on
brain,
particularly
following
extracranial
insults,
has
been
largely
overlooked.
Journal of Personalized Medicine,
Journal Year:
2022,
Volume and Issue:
12(5), P. 706 - 706
Published: April 28, 2022
The
severity
of
ailments
caused
by
SARS-CoV-2
varies
and
the
clinical
picture
has
already
evolved
during
pandemic,
complicating
diagnostics.
In
Poland,
no
study
been
performed
to
assess
patients
across
successive
pandemic
waves.
aim
was
present
characteristics
who
medical
center
because
persistent
symptoms
after
COVID-19,
differences
between
hospitalized/non-hospitalized,
vaccinated/non-vaccinated
individuals
different
waves
in
Poland.
This
is
a
retrospective
evaluating
presentation
COVID-19
from
STOP-COVID
registry
PoLoCOV-Study.
includes
isolation.
patients’
data
were
obtained
suffered
September
2020
December
2021.The
divided
into
groups
according
infection
rate
increase
pattern
(II/III/IV
wave),
status
vaccination
place
Regardless
wave,
most
commonly
reported
weaknesses
cough
headache.
arterial
hypertension
hyperlipidemia
frequent
concomitant
chronic
conditions.
Hospitalized
more
often
weakness
or
while
home-isolated
likely
have
rhinitis
Patients
completed
course
showed
shorter
duration
lower
mean
number
symptoms.
Additionally,
vaccinated
less
taste
and/or
olfactory
dysfunction
than
unvaccinated
individuals.
To
conclude,
persistence
resulted
significant
changes
observed
picture.
Successive
deterioration
subjective
assessment
disease
severity.
A
seemed
occur
frequently
later
Tuberculosis & respiratory diseases,
Journal Year:
2023,
Volume and Issue:
86(3), P. 216 - 225
Published: March 31, 2023
Tuberculosis
(TB)-related
stigma
has
been
well-documented.
Since
the
emergence
of
coronavirus
disease
2019
(COVID-19),
different
organizations
have
alerted
to
fact
that
could
arise
again.
Due
stigma's
negative
effects,
this
qualitative
study
aimed
explore
felt
by
patients
evaluating
following:
COVID-19
and
its
temporal
progression
through
pandemic;
perceived
with
TB
before
during
difference
individuals
who
contracted
both
diseases.A
semi-structured
interview
was
developed
according
available
literature
on
theme.
It
performed
individually
in
2022
upon
receiving
signed
informed
consent.
Participants
were
recruited
a
purposive
sampling
approach
searching
medical
records.
Those
currently
or
previously
had
pulmonary
and/
included.
Data
subjected
thematic
analysis.Nine
interviewed,
including
six
(66.7%)
females.
The
median
age
51±14.7
years.
Four
participants
(44.4%)
completed
high
school
four
never
smokers.
Three
COVID-19.
only
two
Interviews
identified
eight
main
themes:
knowledge
beliefs,
several
misconceptions
identified;
attitudes
towards
disease,
varying
from
social
support
exclusion;
education,
assumed
as
extreme
importance;
internalized
stigma,
self-rejection;
experienced
discrimination
episodes;
anticipated
modifying
actions
for
avoiding
stigma;
judgment
others
prevailed;
evolution
stigma.Individuals
expressed
strong
diseases.
De-stigmatization
respiratory
infectious
diseases
is
crucial
limiting
impact.
World Journal of Clinical Cases,
Journal Year:
2021,
Volume and Issue:
9(24), P. 7218 - 7223
Published: Aug. 24, 2021
BACKGROUNDWe
present
a
rare
case
of
status
epilepticus
in
56-year-old
man
which
arose
as
complication
after
vaccination
with
the
coronavirus
disease
2019
(COVID-19)
mRNA-1273
vaccine.The
patient's
history
included
well-compensated
secondary
epilepsy.The
root
cause
situation
was
fever
had
developed
side
effect
vaccination.
CASE
SUMMARYA
received
first
dose
vaccine
against
severe
acute
respiratory
syndrome-coronavirus-2.The
administered
intramuscularly
(100
mg,
0.5
mL).The
next
morning
found
to
be
suffering
from
and
headaches
while
at
same
time
experiencing
general
weakness.He
lost
consciousness
suddenly
experienced
generalized
clonic
seizures
turned
into
epilepticus.When
Emergency
Medical
Service
arrived
patient
unconscious
spontaneous
breathing
seizures.It
necessary
administer
diazepam
repeatedly.It
also
high
doses
levetiracetam
temporary
propofol.The
brought
under
control
approximately
90
min
transport
Department.A
follow-up
electroencephalogram
no
longer
revealed
abnormal
indications
epileptic
fit.The
temporarily
hospitalized
Intensive
Care
Unit
seven
days
care
discharged
without
any
further
apparent
effects.
Canadian Journal of Gastroenterology and Hepatology,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 9
Published: Nov. 3, 2022
We
studied
2731
patients
with
known
CLD
who
were
hospitalized
at
the
Johns
Hopkins
Health
System
COVID-19
between
March
1,
2020,
and
December
15,
2021.
The
primary
outcome
was
all-cause
mortality,
secondary
outcomes
MV
vasopressors.
Multivariable
Cox
regression
models
performed
to
explore
factors
associated
outcomes.Overall,
80.1%
had
severe
COVID-19,
mortality
8.9%,
12.8%
required
MV,
11.2%
received
vasopressor
support.
Older
underlying
comorbidities
more
likely
have
COVID-19.
There
association
elevated
aminotransferases
total
bilirubin
Hepatic
decompensation
independently
(HR
2.94;
95%
CI
1.23-7.06).
Alcohol-related
liver
disease
(ALD,
HR
2.79,
CI,
1.00-8.02)
increased
risk
for
independent
related
support
chronic
pulmonary
malignancy.COVID-19
infection
in
is
poor
outcomes.
SARS-CoV-2
hepatic
an
of
in-hospital
hazard,
ALD
among
hazard
MV.
Malaysian Journal of Fundamental and Applied Sciences,
Journal Year:
2022,
Volume and Issue:
18(6), P. 630 - 643
Published: Dec. 29, 2022
Treatment
of
COVID-19
that
is
based
on
plants
could
be
a
more
cost-effective
therapy
against
the
disease.
Flavonoids,
group
compounds
have
been
observed
to
various
effects,
including
antiviral
activity,
were
chosen
as
candidate
molecule
for
treatment
COVID-19.
Kalanchoe
Pinnata
one
containing
flavonoids
has
demonstrated
activity.
The
structure
ACE2
and
retrieved
cleaned
from
unnecessary
residues.
was
subjected
molecular
docking
in
order
analyze
binding
affinity.
Following
that,
ADME
properties
each
flavonoid
analyzed
accordingly.
QSAR
analysis
also
performed
type
flavonoid.
Lastly,
dynamics
simulation
conducted.
All
tested
able
bind
human
SARS-CoV-2
Spike
protein,
but
unable
compete
with
them
affinity
protein
lower
compared
ACE2-Spike
interaction.
toxicity
showed
most
ligands
absorbed
by
GI
tract,
low
bioavailability.
cause
no
major
effects
sufficiently
distributed
body.
Molecular
revealed
among
compounds,
quercetin
rutin
interact
stably.
friedelin,
kaempferol,
quercetin,
are
mostly
non-toxic,
high
Cramer
values
indicate
there
initial
safety
impressions
these
molecules
toxicity.
In
conclusion,
potential
drug
development
in-silico
predictions
results
obtained.
Friedelin
Narcissin
whose
proteins
relatively
stronger
had
unstable
interactions
results,
may
further
investigation.
However,
research
required
assess
effectiveness
specially
measure
compounds.
CNS & Neurological Disorders - Drug Targets,
Journal Year:
2022,
Volume and Issue:
22(3), P. 417 - 430
Published: April 6, 2022
Depression
and
anxiety
belong
to
a
family
of
mental
disturbances
that
have
increased
significantly
in
recent
years.
The
etiology
both
disorders
comprises
multiple
complex
factors,
from
genetic
background
environmental
influence.
Since
depression
present
severe
symptoms,
they
represent
greater
clinical
burden
therapeutic
difficulty.
Currently,
standardized
diagnostic
procedures
for
allow
the
addition
further
treatments,
including
psychotherapy
and/or
pharmacological
intervention,
with
effective
outcomes.
However,
steps
should
be
considered
regard
consideration
endocannabinoid
system's
role
anxiety.This
study
aimed
review
evidence
animal
research
studies
on
cannabinoid
receptors,
major
endocannabinoids
-anandamide
(AEA)
2-arachidonoylglycerol
(2-AG)-
enzymes
related
synthesis
degradation
these
chemicals
as
putative
biomarkers
elements
included
online
search,
identification,
analysis
articles
(basic
trials)
published
English
PubMed
linked
AEA,
2-
AG,
associated
anxiety.The
neurobiological
relevance
system
offers
or
manipulation
this
potential
strategy
management
mood
disorders,
anxiety.Although
described
approach
is
promising,
no
solid
yet
available,
along
additional
experiments
using
models
mimic
human
anxiety,
trials
are
needed
explore
well
anandamide
membrane
transporter,
none
which
been
adequately
studied
anxiety.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: March 31, 2023
Inflammation
and
cytokine
storm
have
been
reported
to
be
the
main
cause
of
acute
symptoms
coronavirus
disease
(COVID-19).
Diet-induced
inflammation
may
affect
condition
patients
with
COVID-19.
Therefore,
this
study
aimed
investigate
relationship
between
severity,
inflammatory
immune
system
biomarkers,
dietary
index
(DII)
in
COVID-19.This
cross-sectional
was
conducted
on
500
adult
Patients
were
divided
into
mild,
moderate,
severe
conditions
based
clinical
laboratory
evidence.
A
validated
food
frequency
questionnaire
(FFQ)
used
determine
DII
energy-adjusted
(E-DII)
scores.
The
serum
C-reactive
protein
(CRP)
level
blood
cell
count
measured
for
all
patients.
Multiple
linear
regression
explore
association
E-DII
CRP,
counts,
hospitalization
COVID-19.Coronavirus
(COVID-19)
higher
had
consumption
fat
carbohydrate
lower
intakes
protein,
anti-inflammatory
nutrients,
garlic,
caffeine,
tea,
onion,
fiber
(P
<
0.05).
There
a
positive
CRP
(β
=
1.024,
P
0.001),
1.062,
WBC
0.486,
0.009),
neutrophil
0.565,
neutrophil-to-lymphocyte
ratio
0.538,
0.001)
negative
lymphocyte
-0.569,
0.001).
1.645,
0.417,
0.02),
0.35,
0.03).There
is
correlation
inflammation,
hyperactivation,
length
hospital
stay
Further
longitudinal
studies
are
necessary.
