The Impact of Interleukin-21 and 23 Serum Level and Gene Expression in Celiac Disease among Sample of Iraqi Patients

Asian Journal of Dairy and Food Research, Journal Year: 2025, Volume and Issue: Of

Published: Jan. 7, 2025

Background: Celiac disease (CD) is an autoimmune characterized by chronic inflammation that essentially affects the small intestine and caused food contain gluten. This research aimed to explore impact of interleukin 21 (IL-21) 23 (IL-23) on development in Iraqi patients. Methods: Forty adults have CD were enrolled study with age range between 15-60 years average 36.60± 2.03 years. The diagnosis was confirmed serological examinations intestinal endoscopy Gastroenterology Liver Teaching Hospital Medical City Baghdad a forty healthy subjects included this as control group 16-59 32.22±1.97 blood serum examined for Anti tissue transglutaminase (tTG) IgA IgG (IgA ant-tTG ant-tTG) Anti-DGP ant-DGP) antibodies well IL-21 IL-23 using enzyme-linked immunoassay technique ((ELISA). Also, gene expression peripheral patients determined quantitative real-time PCR (qRT-PCR) assay. Result: results showed levels anti-tTG (IgA, IgG) anti-gliadin (IgA) significantly higher than (25.13±1.12, 19.86±1.13, 32.01±2.36 vs. 12.62±1.04, 6.83±0.82, 21.59±1.44 U/ml, respectively; p less 0.01). In addition, level increased high significant differences (490.02±20.46 565.22±22.84 vs 106.87±4.23 256.03±13.52 pg/ml; 0.01), respectively. revealed 3.33±0.35 2.83±0.27 fold change comparison control.

Language: Английский

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Phytochemistry of Punica granatum Fruit: Its Nutritional and Biological Potential

Bioactivities, Journal Year: 2024, Volume and Issue: 2(1), P. 57 - 73

Published: June 23, 2024

The present review provides a comprehensive overview of the phytochemistry, nutritional composition, and therapeutic implications associated with consumption pomegranate (Punica granatum) fruit, renowned for its dual role as taste delicacy medicinal agent. A detailed exploration phytochemical composition is undertaken. Recognized myriad health benefits, this fruit has been historically employed remedy diverse disorders, leaves, peel, bark demonstrating efficacy in treating gastrointestinal issues leading to diarrhea. Notably, juice utilized cholera, while oil extracted from seeds exhibits notable addressing skin breast cancer. underscores presence bioactive compounds, including flavonoids, tannins, ellagitannins, catechin, phenols, across various species P. granatum. In addition rich profile, emerges nutritionally boasting significant quantities vitamins C D, magnesium, potassium, dietary fibers. Its aligns properties, encompassing anti-inflammatory, antioxidant, anticancer, antimicrobial attributes. single cup arils contains 72 calories, 16 g carbohydrates, 3 fiber. This serves deepen our understanding multifaceted nature pomegranate, addresses emerging technological advancements phytochemistry.

Language: Английский

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Effect of bee venom (Apis mellifera) on liver damage in mice with Ehrlich ascites carcinoma

Regulatory Mechanisms in Biosystems, Journal Year: 2025, Volume and Issue: 33(1), P. e25040 - e25040

Published: March 4, 2025

Cancer is a terrible illness that has enormously detrimental effects on society, the economy, health care and personal lives. In 2012, there were around 14.1 million cancer cases diagnosed worldwide, with 52.5% of those instances occurring in men 47.5% women. By 2030, number predicted to increase 21.7 million. this was responsible for 8.2 fatalities globally; by end rise 13.0 The purpose our study evaluate capability Apis mellifera venom (A.M.) reduce renal toxicity tissue damage caused Ehrlich ascites carcinoma (EAC) mice. A total forty female Swiss albino mice divided evenly among four groups (G1, control, G2, A.M., G3, EAC, G4, EAC + A.M.). findings demonstrated that, comparison group, addition co-treated resulted lower levels alpha-fetoprotein (AFP), ANA, anti-dsDNA, AST, ALT, ALP. Liver slices from showed several histological alterations, including mild fibrosis, noticeable diffuse necrosis hepatic parenchyma, inflammatory cells, clogged blood sinusoids. Conversely, liver sections EAC+Apis modest improvement hepatocytes.

Language: Английский

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Impact of Chia (Salvia hispanica) Seeds Extract on Ehrlich Ascites Model Induced Kidney Toxicity in Female Mice

Asian Journal of Dairy and Food Research, Journal Year: 2024, Volume and Issue: Of

Published: June 28, 2024

Background: Ehrlich ascites carcinoma (EAC) is an undifferentiated of the breast that was initially hyperdiploid, 100% malignantand had a short life span. It also high transplantability rate, no recurrence and rapid dissemination. Methods: Therefore, our study designed to assess potential ameliorative ability Chia (Salvia hispanica) seeds extract (CSE) on induced kidney toxicity tissue damage in mice. Forty female Swiss albino mice all were split equally into four teams (Gp1, control; Gp2, CSE; Gp3, EAC; Gp4, EAC+CSE). Result: Current results revealed that; EAC elevated levels serum urea, creatinine, potassium ions, chloride renal injury significant depletion sodium calcium ions as compared normal control. In addition variable pathological changes glomeruli tubules marked damage, degeneration tissues, moderate glomerular atrophyand cellular infiltration. Treatment with CSE (EAC+CSE) improved functions structure against where take place elevation EAC. One may draw conclusion Having protect kidneys from cells toxicity.

Language: Английский

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Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Egyptian Journal of Cancer and Biomedical Research., Journal Year: 2024, Volume and Issue: 8(2), P. 27 - 34

Published: June 1, 2024

Background: Essential oils (SO) are organic substances that extracted from plant parts, which have been thought to anti-cancer characteristics. Aim: To investigate the potential protective effects of SO against liver toxicity induced in EAC–bearing female mice. Materials and Methods: Forty mice were equally divided into four groups (Gps). Gp1 was served as control, Gp2 treated with SO, Gp3 inoculated EAC, Gp4 concomitantly EAC + SO. Results: Data showed treatment EAC-bearing led an amelioration aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP) activities. also increases total protein levels compared group. There a significant improvement expression GFAP brain tissues EAC/SO group Conclusion: The current results indicate hepatoprotective essential oils.

Language: Английский

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Therapeutic Effect of Essential Oils (Citrus sinensis) against Ehrlich Ascites Model Induced Renal Toxicity in Female Mice

Agricultural Science Digest - A Research Journal, Journal Year: 2024, Volume and Issue: Of

Published: Aug. 23, 2024

Background: Cancer is one of the most dangerous diseases twentieth century and speed its spread horrific. It characterized by cellular growth invades all tissues body. In recent years, countries world have turned to cancer research in order identify new drugs treat from various sources , common disease that causes death this attributed many pathological factors, such as reactive oxygen species, which contribute initiation, development cancer. Methods: Our current aims investigate therapeutic role essential oils (C.S.) against Ehrlich Tumor renal damage Mice. The mice were divided into four group (Gp1, control group, Gp2, Essential (C.S) Gp3, EAC Gp4, with (C.S). Result: Results showed pretreated (G4) lead an improvement urea, creatinine levels when compared group. Through our results, it was shown treatment improved urea comparing Gp3. noted kidney tissue VEGF protein expression Gp4 Gp3 Groups. could be concluded has a possible benefit kidneys induce Toxicity.

Language: Английский

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In Vitro Anti-diabetic Activity of Pomegranate Peel Extract-Mediated Strontium Nanoparticles

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 30, 2023

Introduction Type 2 diabetes mellitus and its associated health complications represent a significant public issue due to wide prevalence. The primary disadvantages of current oral anti-diabetic drugs are their limited bio-availability quick release, which necessitates more frequent dosing. Similar limitations encountered when using natural products for the management type diabetes. Consequently, nanoparticles have been developed with goal enhancing physicochemical stability drugs, thereby improving bio-availability. In view given background, present study aimed explore efficacy strontium derived from pomegranate peel extract in managing mellitus. Materials methods aqueous was prepared standard protocol were by green synthesis method extract. assessed inhibitory potential against α-amylase α-glucosidase enzymes activity 3,5-dinitrosalicylic acid (DNSA) p-nitro-phenyl-ɑ-D glucopyranoside (p-NPG) assays, respectively. Results peel-mediated (PP-Sr NPs) acarbose effect diabetic enzymes, α-amylase, at different concentrations range 5-160 μg/ml. results showed that PP-Sr NPs exhibited maximum inhibition 79.28% 76.17% respectively highest concentration 160 Acarbose 88.02% 84.47% found be concentration-dependent. Conclusion From results, it is concluded may useful decreasing postprandial glucose levels. Further studies vitro cell lines vivo models substantiate antidiabetic NPs.

Language: Английский

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Effect of Some natural products against Ehrlich Ascites Carcinoma in mice: A Review

Journal of AL-Farabi for Medical Sciences, Journal Year: 2024, Volume and Issue: 1(1)

Published: Feb. 29, 2024

Cancer is a serious disease and it one of the main causes death, considered second cause, after people who suffer from heart failure. Through statistics, Breast cancer most common types cancer, with rate 99% in women 1% men. It very complex, patients this type may face numerous challenges during their treatment period. was determined that death had decreased by 1.5%, but expected to increase future due an cases (breast, prostate). Ehrlich model grows inside mouse. Its origin spontaneous mammary carcinoma, when spreads within mouse, takes two forms, either ascitic or solid. Ehrlich's ascites carcinoma breast has high importance scientific research. undifferentiated short life. This used for first time 1932, mouse abdomen, fluid obtained called ( ascites) liquid substance on which cells depend consider food means rapid tumor growth, EAC deficiency anemia thus decrease red blood hemoglobin, urea creatinine, liver enzymes total protein.Natural products are only effective lead development drugs, especially anti-cancer drugs anti-inflammatories. studies, become clear natural source drugs.

Language: Английский

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Molecular Mechanisms of Clozapine-Induced Pancreatic Damage and its Modulation by L-Carnitine in a Rat Model

Egyptian Society of Clinical Toxicology Journal, Journal Year: 2024, Volume and Issue: 12(1), P. 182 - 199

Published: June 1, 2024

Background: Clozapine (CLZ) has been considered the mainstay drug in treatment of resistant schizophrenia. Diabetes mellitus befallen during clozapine therapy. L-carnitine (LC) protective effects against many health hazards. Aim work: This experiment aimed to examine molecular mechanisms pancreatic insult caused by CLZ rats and possible ameliorating effect LC that toxicity. Material Methods: Thirty-five adult male albino were allocated into five groups equally: control (negative vehicle), LC-treated group received 350 mg/kg/day LC, CLZ-treated gavaged 25 combined LC+CLZ same previous doses. All treatments given orally for 4 weeks. Results: CLZ-treatment triggered a significant rise mean values body weight (BW) serum fasting blood glucose (FBG), amylase, insulin, Triglyceride Glucose (TyG) Index Homeostatic Model Assessment Insulin Resistance (HOMA-IR). Also, upsurge lipid peroxidation pro-inflammatory (Nuclear Factor Kappa-light-chain-enhancer activated B cells (NF-kB)) accompanying decrease catalase (CAT), Hemo oxygenase-1 (HO-1) enzyme nuclear factor erytheroid 2-related (Nrf2) activities anti-inflammatory (IL-10), decreased expression Peroxisome proliferator receptor alfa (PPAR-α) tissues occurred. There was histological immunohistochemical evidence tissue injury with increased collagen fibers. The abnormalities reversed when group. Conclusion: can ameliorate oxidant, inflammatory, apoptotic impacts induced CLZ.

Language: Английский

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Effect of Artemisia Vulgaris on Liver of Albino Mice Exposed to Cisplatin

Biomedical & Pharmacology Journal, Journal Year: 2024, Volume and Issue: 17(2), P. 1341 - 1346

Published: June 25, 2024

The herb Arte(also known as Artemisia V.) is widely used to treat a variety of illnesses, including gastrointestinal disorders, infections, and fungal infections. antibacterial component that makes this ingredient so beneficial essential for treating septicemia the prebiotic. This study looked at how vulgaris L. protected rats' livers from toxic treatment cisplatin. In virtual medicine, cisplatin frequently employed. Numerous forms human cancer, such advanced uterine esophageal privacy, ovarian have been successfully treated with it. infection other like disease. experiment, thirty 25–30 g white secretive mice aged 12 weeks were used. 72 hours spent soaking blood tissue samples in 4% paraformaldehyde before they paraffin embedded. Hematoxylin-eosin (H, E) staining was applied after sections cut into 3-m pieces embedded wax. Establishing extraction L 400 mg/kg/day extract greatest efficiency technique, separated groups revealed. proved extract's efficiency. finding offers thorough reported support use purifications A. medical systemic poisoning additional benefits definite therapeutic effects potent histochemical cancerous tissues.

Language: Английский

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