Ophthalmic Research,
Journal Year:
2021,
Volume and Issue:
64(6), P. 871 - 887
Published: Jan. 1, 2021
Optical
coherence
tomography
Angiography
(OCT-A)
represents
a
revolution
in
the
noninvasive
evaluation
of
retinal
and
choroidal
circulation
especially
detecting
early
clinical
signs
diabetic
disease
(DRD).
With
appropriate
use,
OCT-A
characteristics
measurements
have
potential
to
become
new
imaging
biomarkers
managing
treating
DRD.
Major
challenges
include
(a)
provision
standardized
outputs
from
different
instruments
providing
terminology
correctly
interpret
data;
(b)
presence
artifacts;
(c)
absence
grading
or
interpretation
method
DRD,
similar
that
already
established
fundus
photography;
(d)
establishing
how
might
be
able
provide
surrogate
markers
demonstrate
blood
barrier
breakdown
vascular
leakage,
commonly
associated
with
In
fact,
guidelines
for
DRD
are
still
evolving.
The
quantitative
data
offer
unique
opportunity
develop
tools
based
on
artificial
intelligence
assist
clinicians
diagnosing,
monitoring,
patients
diabetes.
addition,
has
useful
tool
cardiovascular
diseases
neurological
including
cognitive
impairment.
This
article
written
by
members
Diabetic
Retinopathy
expert
committee
European
Vision
Clinical
Research
network
will
review
available
evidence
use
as
an
biomarker
discuss
limits
current
application
well
future
developments
its
both
practice
research
trials
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 24, 2024
Abstract
Myocardial
infarction
is
defined
as
a
sudden
decrease
or
interruption
in
blood
flow
to
the
coronary
arteries,
causing
ischemic
necrosis
of
corresponding
cardiomyocytes.
It
unclear
whether
systemic
macrovascular
alterations
are
associated
with
retinal
microvascular
changes.
This
study
utilized
optical
coherence
tomography
angiography
(OCTA)
compare
variations
conjunctival
vascular
density
and
fundus
vessel
between
patients
myocardial
(MI)
healthy
controls.
recruited
16
(32
eyes)
MI
controls
eyes).
The
superficial
layer
(SRL),
deep
(DRL)
capillary
plexus
each
eye
were
evaluated
by
OCTA.
Parameters
measured
included
temporal
capillary,
(MIR)
(MAR)
total
MIR
(TMI).
region
was
hemisphere
segmentation
(SR,
SL,
IL,
IR),
annular
partition
(C1,
C2,
C3,
C4,
C5
C6),
modified
early
treatment
diabetic
retinopathy
(R,
S,
L,
I)
methods.
In
macular
area,
densities
displayed
notable
variations.
layers,
TMI,
MIR,
MAR,
well
C1,
C6
regions,
significantly
lower
(p
<
0.05
each).
TMI),
C2
regions
contrast,
higher
than
0.001).
layers
conjunctiva
differ
OCTA
effective
detecting
changes
ocular
microcirculation.
Life,
Journal Year:
2024,
Volume and Issue:
14(4), P. 448 - 448
Published: March 28, 2024
Background:
Retinal
microvascular
anomalies
have
been
identified
in
patients
with
cardiovascular
conditions
such
as
arterial
hypertension,
diabetes
mellitus,
and
carotid
artery
disease.
We
conducted
a
systematic
review
meta-analysis
(PROSPERO
registration
number
CRD42024506589)
to
explore
the
potential
of
retinal
vasculature
biomarker
for
diagnosis
monitoring
coronary
disease
(CAD)
through
optical
coherence
tomography
(OCT)
angiography
(OCTA).
Methods:
systematically
examined
original
articles
Pubmed,
Embase,
Web
Science
databases
from
their
inception
up
November
2023,
comparing
features
between
CAD
control
groups.
Studies
were
included
if
they
reported
sample
mean
standard
deviation
or
median
range
and/or
interquartile
(which
computed
into
deviation).
Review
Manager
5.4
(The
Cochrane
Collaboration,
2020)
software
was
used
calculate
pooled
effect
size
weighted
difference
95%
confidence
intervals
(CI)
by
random-effects
inverse
variance
method.
Results:
Eleven
studies
meeting
inclusion
criteria
incorporated
meta-analysis.
The
findings
indicated
significant
decrease
nerve
fiber
layer
(WMD
−3.11
[−6.06,
−0.16]),
subfoveal
choroid
−58.79
[−64.65,
−52.93]),
overall
thickness
−4.61
[−7.05,
−2.17])
among
compared
controls
(p
<
0.05).
Furthermore,
vascular
macular
density
notably
lower
patients,
particularly
superficial
capillary
plexus
(foveal
vessel
WMD
−2.19
[−3.02,
−1.135],
p
0.0001).
Additionally,
foveal
avascular
zone
area
statistically
larger
group
52.73
[8.79,
96.67],
=
0.02).
Heterogeneity
(I2
>
50%)
most
except
thickness,
retina
density.
Conclusion:
current
suggests
that
vascularization
could
function
noninvasive
biomarker,
providing
additional
insights
beyond
routine
examinations
assessing
dysfunction
arteries.
Acta Ophthalmologica,
Journal Year:
2021,
Volume and Issue:
100(2), P. 225 - 233
Published: Feb. 24, 2021
To
investigate
the
association
between
retinal
microvasculature
and
presence
severity
of
coronary
artery
disease
(CAD)
using
optical
coherence
tomography
angiography
(OCTA).The
cross-sectional
study
was
conducted
in
Guangdong
Provincial
People's
Hospital,
China.
Retinal
parameters
were
measured
by
OCTA
optic
disc,
including
vessel
density
(VD)
nerve
fibre
thickness
radial
peripapillary
capillary.
In
terms
entire
macula,
VD
superficial
capillary
plexus
(SCP),
deep
(DCP)
foveal
(FD-300)
included.
The
Gensini
score
used
to
evaluate
obstructive
lesions
CAD
patients.A
total
410
participants
(270
patients
140
controls)
Overall,
showed
significantly
greater
odds
having
lower
versus
higher
for
mean
SCP,
OR
=
2.33
(95%
CI
1.49-3.65);
parafoveal
2.68
1.70-4.23);
perifoveal
2.36
1.49-3.72).
Additionally,
DCP,
4.04
2.53-6.45);
4.08
2.54-6.55);
3.88
2.43-6.19).
Among
patients,
DCP
associated
with
adjusted
scores
(p
0.004
DCP;
p
0.035
0.006
DCP).SCP
found
be
among
whole
population,
while
patients.
stenosis
Ophthalmic Research,
Journal Year:
2021,
Volume and Issue:
64(6), P. 871 - 887
Published: Jan. 1, 2021
Optical
coherence
tomography
Angiography
(OCT-A)
represents
a
revolution
in
the
noninvasive
evaluation
of
retinal
and
choroidal
circulation
especially
detecting
early
clinical
signs
diabetic
disease
(DRD).
With
appropriate
use,
OCT-A
characteristics
measurements
have
potential
to
become
new
imaging
biomarkers
managing
treating
DRD.
Major
challenges
include
(a)
provision
standardized
outputs
from
different
instruments
providing
terminology
correctly
interpret
data;
(b)
presence
artifacts;
(c)
absence
grading
or
interpretation
method
DRD,
similar
that
already
established
fundus
photography;
(d)
establishing
how
might
be
able
provide
surrogate
markers
demonstrate
blood
barrier
breakdown
vascular
leakage,
commonly
associated
with
In
fact,
guidelines
for
DRD
are
still
evolving.
The
quantitative
data
offer
unique
opportunity
develop
tools
based
on
artificial
intelligence
assist
clinicians
diagnosing,
monitoring,
patients
diabetes.
addition,
has
useful
tool
cardiovascular
diseases
neurological
including
cognitive
impairment.
This
article
written
by
members
Diabetic
Retinopathy
expert
committee
European
Vision
Clinical
Research
network
will
review
available
evidence
use
as
an
biomarker
discuss
limits
current
application
well
future
developments
its
both
practice
research
trials
