Stimulatory responses in α‐ and β‐cells by near‐infrared (810 nm) photobiomodulation DOI

Caleb Liebman,

Sheccid Alejandra Loya,

Michael C. Lawrence

et al.

Journal of Biophotonics, Journal Year: 2021, Volume and Issue: 15(3)

Published: Nov. 27, 2021

Significant efforts have been committed to better understand and regulate insulin secretion as it has direct implications on diabetes. The first phase of biphasic in response glucose lasts about 10 minutes, followed by a more sustained release persisting several hours. Attenuated the is typically associated with abnormal β-cells. While near-infrared photobiomodulation (PBM) demonstrates potential for multiple therapeutic applications, photostimulatory effects α- β-cells remain be further elucidated. Herein, we demonstrate that 810 nm PBM exposure at fluence 9 J/cm2 can elevate intracellular reactive oxygen species within 15 minutes following photostimulation. In addition, calcium spiking showed an approximately 3-fold increase both ATC1 (α-cells) BTC6 (β-cells) correlates hormone stimulation. Our findings could lay foundation development non-biologic therapeutics augment islet transplantation.

Language: Английский

Transcranial Photobiomodulation for Executive Function in Bipolar Disorder (TPEB): Study Protocol DOI Creative Commons
David Richer Araujo Coelho, Aura Maria Hurtado Puerto, Willians Fernando Vieira

et al.

Photonics, Journal Year: 2024, Volume and Issue: 11(8), P. 761 - 761

Published: Aug. 15, 2024

Bipolar disorder (BD) is a debilitating psychiatric characterized by mood disturbances and executive function deficits. Impairments in function, including impulsivity, significantly impact the daily lives of individuals with BD. Transcranial photobiomodulation (t-PBM) near-infrared light offers promising noninvasive neurostimulation approach to improve cognitive function. The Photobiomodulation for Executive Function Disorder (TPEB) study aims explore potential t-PBM BD impairments. This will include 20 adults who each receive one sham session on first day stimulation (treatment 1), followed four days 2 5). Cerebral blood flow changes be evaluated using functional magnetic resonance imaging. Impulsivity, decision-making, reward responsiveness assessed Barratt Impulsiveness Scale, Iowa Gambling Task, gambling task that evaluates reward. outcomes involve examining cerebral flow, improvements reductions impulsivity manic symptoms. TPEB provide valuable insights into as therapeutic intervention enhance

Language: Английский

Citations

4
Photobiomodulation Therapy Restores IL-10 Secretion in a Murine Model of Chronic Asthma: Relevance to the Population of CD4+CD25+Foxp3+ Cells in Lung DOI Creative Commons
Auriléia Aparecida de Brito, Tawany Gonçalves Santos,

Karine Zanella Herculano

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 12

Published: Feb. 2, 2022

It is largely known that photobiomodulation (PBM) has beneficial effects on allergic pulmonary inflammation. Our previous study showed an anti-inflammatory effect of the PBM in acute experimental model asthma, and we see this mechanism partly dependent IL-10. However, it remains unclear whether activation regulatory T cells mediated by a chronic asthma. In sense, objective was to verify role inflammatory response asthma model. The protocol used for induction administration OVA subcutaneously (days 0 14) intranasally (3 times/week, 5 weeks). On day 50, animals were sacrificed evaluation different parameters. diode, with wavelength 660 nm, power 100 mW, J 50 s/point, three application points. results decreases macrophages, neutrophils, lymphocytes bronchoalveolar lavage fluid (BALF). Moreover, decreased release cytokines lung, mucus, collagen airways mechanics. When analyzed percentage Treg group irradiated laser, verified increase these cells, as well IL-10 BALF. Therefore, conclude use therapy airway inflammation attenuated process, functional structural parameters, probably due cells.

Language: Английский

Citations

19
Combination of Group Singular Value Decomposition and eLORETA Identifies Human EEG Networks and Responses to Transcranial Photobiomodulation DOI Creative Commons
Xinlong Wang, Hashini Wanniarachchi,

Anqi Wu

et al.

Frontiers in Human Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: May 10, 2022

Transcranial Photobiomodulation (tPBM) has demonstrated its ability to alter electrophysiological activity in the human brain. However, it is unclear how tPBM modulates brain electroencephalogram (EEG) networks and related cognition. In this study, we recorded 64-channel EEG from 44 healthy humans before, during, after 8-min, right-forehead, 1,064-nm or sham stimulation with an irradiance of 257 mW/cm 2 . data processing, a novel methodology by combining group singular value decomposition (gSVD) exact low-resolution electromagnetic tomography (eLORETA) was implemented performed on noise-free time series. The gSVD+eLORETA algorithm produced 11 gSVD-derived principal components (PCs) projected 2D sensor 3D source domain/space. These PCs took more than 70% weight entire signals were justified as networks. Finally, baseline-normalized power changes each network frequency band (delta, theta, alpha, beta gamma) quantified during first 4-min, second post tPBM/sham periods, followed comparisons frequency-specific between conditions. Our results showed that tPBM-induced increases alpha powers occurred at default mode network, executive control frontal parietal lateral visual network. Moreover, decompose into individual, independent facilitated better visualize significant decreases gamma tPBM. Many similarities found cortical locations SVD-revealed fMRI-identified resting-state This consistency may shed light mechanistic associations tPBM-modulated improved cognition outcomes.

Language: Английский

Citations

17
Pilot study comparing effects of infrared neuromodulation and transcranial magnetic stimulation using magnetic resonance imaging DOI Creative Commons
Sophia A. Bibb,

Emily Yu,

M. Fiona Molloy

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 13, 2025

No prior work has directly compared the impacts of transcranial photobiomodulation (tPBM) and magnetic stimulation (TMS) on human brain. This within-subjects pilot study compares effects tPBM TMS somatomotor cortex brain structural functional connectivity. Eight healthy participants underwent four lab visits each, each visit consisting a pre-stimulation MRI, or sham, post-stimulation respectively. Stimulation sham sessions were counterbalanced across subjects. Collected measures included MRI data, data from finger-tapping task, resting state connectivity, Analyses indicated increased activation left region during right-hand task following both TMS. Additionally, trending increases in left-lateralized connectivity M1 to thalamus observed after tPBM, but not Thus, may be superior at inducing changes connected nodes cortex, although further research is warranted explore potential therapeutic benefits clinical utility tPBM.

Language: Английский

Citations

0
基于近红外光的脑功能成像与神经调控技术（特邀） DOI

贺江山 He Jiangshan,

杨玉强 Yang Yuqiang,

蒋明哲 Jiang Mingzhe

et al.

Chinese Journal of Lasers, Journal Year: 2025, Volume and Issue: 52(9), P. 0907302 - 0907302

Published: Jan. 1, 2025

Citations

0
Metabolic Connectivity and Hemodynamic-Metabolic Coherence of Human Prefrontal Cortex at Rest and Post Photobiomodulation Assessed by Dual-Channel Broadband NIRS DOI Creative Commons
Xinlong Wang,

Liang-Chieh Ma,

Sadra Shahdadian

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(1), P. 42 - 42

Published: Jan. 5, 2022

Billions of neurons in the human brain form neural networks with oscillation rhythms. Infra-slow (ISO) presents three main physiological sources: endogenic, neurogenic, and myogenic vasomotions. Having an vivo methodology for absolute quantification ISO from can facilitate detection abnormalities cerebral hemodynamic metabolic activities. In this study, we introduced a novel measurement-plus-analysis framework non-invasive prefrontal by (1) taking dual-channel broadband near infrared spectroscopy (bbNIRS) measurements 12 healthy humans during 6-min rest 4-min post transcranial photobiomodulation (tPBM) (2) performing wavelet transform coherence (WTC) analysis on measured time series data. The WTC indexes (IC, between 0 1) enabled assessment ipsilateral hemodynamic-metabolic bilateral functional connectivity each band cortex. At rest, was consistent across bands (IC ≅ 0.66), while relatively weaker. For post-tPBM/sham comparison, our analyses revealed key findings: 8-min, right-forehead, 1064-nm tPBM enhanced amplitude bilaterally, promoted neurogenic rhythm, (3) made effect endothelial cells, causing alteration side

Language: Английский

Citations

16
Enhancement of Frequency-Specific Hemodynamic Power and Functional Connectivity by Transcranial Photobiomodulation in Healthy Humans DOI Creative Commons
Nghi Cong Dung Truong, Xinlong Wang, Hashini Wanniarachchi

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 10, 2022

Transcranial photobiomodulation (tPBM) has been considered a safe and effective brain stimulation modality being able to enhance cerebral oxygenation neurocognitive function. To better understand the underlying neurophysiological effects of tPBM in human brain, we utilized 111-channel functional near infrared spectroscopy (fNIRS) system map hemodynamic responses over whole head 8-min with 1,064-nm laser given on forehead 19 healthy participants. Instead analyzing broad-frequency signals (0-0.2 Hz), investigated frequency-specific three infra-slow oscillation (ISO) components consisting endogenic, neurogenic, myogenic vasomotions. Significant changes induced by spectral power oxygenated hemoglobin concentration (Δ[HbO]), connectivity (FC), global network metrics at each ISO frequency bands were identified mapped topographically for comparisons. Our novel findings revealed that significantly increased endogenic Δ[HbO] powers right frontopolar area site. Also, demonstrated enabled significant enhancements FC across cortical regions as well several metrics. These consistent recent reports met expectation is highly associated endothelial activity, which stimulated tPBM-evoked nitric oxide (NO) release.

Language: Английский

Citations

15
Neuromodulation of brain power topography and network topology by prefrontal transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hashini Wanniarachchi

et al.

Journal of Neural Engineering, Journal Year: 2022, Volume and Issue: 19(6), P. 066013 - 066013

Published: Nov. 1, 2022

Objective.Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and patients with Alzheimer's disease. In this study, we aimed to identify key cortical regions that present significant changes caused by tPBM the electroencephalogram (EEG) oscillation powers functional connectivity human brain.Approach. A 64-channel EEG was recorded from 45 participants during a 13 min period consisting of 2 baseline, 8 tPBM/sham intervention, 3 recovery. After pre-processing normalizing data at five rhythms, cluster-based permutation tests were performed for multiple comparisons spectral power topographies, followed graph-theory analysis as topological approach quantification brain metrics global nodal/cluster levels.Main results. enhancement observed clusters channels over frontoparietal alpha band centroparietal beta band. The measures network revealed reduction synchronization, efficiency, small-worldness connectivity, implying an complexity. addition, band, nodal graphical demonstrated increases local information integration centrality frontal clusters, accompanied decrease segregation bilateral frontal, left parietal, occipital regions.Significance.Frontal increased frontal-central-parietal regions, enhanced complexity beta-wave network, augmented flow oscillations across prefrontal regions. This study sheds light on potential link between electrophysiological effects improvement induced tPBM.

Language: Английский

Citations

15
Repeated Photobiomodulation Induced Reduction of Bilateral Cortical Hemodynamic Activation During a Working Memory Task in Healthy Older Adults DOI Creative Commons
Zhishan Hu, Xiujuan Qu,

Lexuan Li

et al.

IEEE Journal of Biomedical and Health Informatics, Journal Year: 2023, Volume and Issue: 27(6), P. 2876 - 2885

Published: March 20, 2023

Transcranial photobiomodulation (tPBM) is an emerging non-invasive light-based neuromodulation technique that shows promising potential for improving working memory (WM) performance in older adults. However, the neurophysiological mechanisms associated with tPBM underlie improvement of WM and persistence such have not been investigated. Sixty-one healthy adults were recruited to receive a baseline sham stimulation, followed by one-week active (12 min daily, 1064-nm laser, 250 mW/cm 2 ) three-week follow-ups. N-back task was conducted on post-stimulation baseline, first (Day 1) seventh 7) days treatment, at During task, functional near-infrared spectroscopy (fNIRS) imaging employed record cortical hemodynamic changes. Brain activations during follow-up sessions compared determine how had changed activity long these changes persisted. We found stimulation Day 1 induced significantly decreased activation right hemisphere 3-back. The expanded from only both hemispheres 7. persisted one week supramarginal gyrus left angular two weeks somatosensory association cortex. These accompanied improved accuracy N-back. findings provide important evidence understanding neural underlying cognitive enhancement after tPBM.

Language: Английский

Citations

9
Effect of NIR light on the permeability of the blood-brain barriers in in vitro models DOI Creative Commons
Ting Zhou, Tymish Y. Ohulchanskyy, Junle Qu

et al.

Biomedical Optics Express, Journal Year: 2021, Volume and Issue: 12(12), P. 7544 - 7544

Published: Nov. 8, 2021

The blood-brain barrier (BBB) is a dynamic between the blood microcirculation system and brain parenchyma, which plays an important role in pathogenesis of variety neurological diseases. Meanwhile, non-invasive therapeutic approach photobiomodulation (PBM) has emerged as promising treatment for disorders through irradiation with near infrared (NIR) light. However, despite multiple encouraging results reported PBM vitro vivo, mechanisms its effect on brain, especially BBB, remain barely known. Herein, NIR light BBB models was studied. 808 nm laser at doses 10 30 J/cm2 found to significantly increase permeability this model. showed that affected mitochondria cells models, leading mitochondrial activity, reactive oxygen species (ROS) level Ca2+ influx. activity matrix metalloproteinases expression tight junction proteins endothelial were be inhibited by light, resulting permeability. This study suggested new strategy drug transport across development treatments disorders.

Language: Английский

Citations

20