Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2022, Volume and Issue: 40(11), P. 771 - 773
Published: Nov. 1, 2022
Language: Английский
Science Advances, Journal Year: 2022, Volume and Issue: 8(48)
Published: Dec. 2, 2022
Transcranial photobiomodulation (tPBM) is a safe and noninvasive intervention that has shown promise for improving cognitive performance. Whether tPBM can modulate brain activity thereby enhance working memory (WM) capacity in humans remains unclear. In this study, we found 1064-nm applied to the right prefrontal cortex (PFC) improves visual increases occipitoparietal contralateral delay (CDA). The CDA set-size effect during retention mediated between subsequent WM capacity. behavioral benefits corresponding changes were absent with at wavelength of 852 nm or stimulation left PFC. Our findings provide converging evidence PFC improve
Language: Английский
Citations
49
Stroke, Journal Year: 2024, Volume and Issue: 55(6), P. 1641 - 1649
Published: April 4, 2024
The current management of patients with stroke intravenous thrombolysis and endovascular thrombectomy is effective only when it timely performed on an appropriately selected but minor fraction patients. development novel adjunctive therapy highly desired to reduce morbidity mortality stroke. Since endothelial dysfunction implicated in the pathogenesis featured suppressed nitric oxide synthase (eNOS) concomitant deficiency, restoring represents a promising approach treating injury.
Language: Английский
Citations
9
Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15
Published: April 26, 2024
Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological conditions, such as depression, traumatic brain injury, and autism spectrum disorder (ASD).
Language: Английский
Citations
8
Journal of NeuroEngineering and Rehabilitation, Journal Year: 2024, Volume and Issue: 21(1)
Published: April 10, 2024
Abstract A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical cadaveric approaches, which light stimuli were applied head and/or neck. PubMed, Scopus, Web of Science Google Scholar databases search. total 2133 records screened, from 97 this review. that extracted analysed each article device design, actuation area, site, wavelength, mode operation, power density, energy output, per session treatment time. To organize information, 11 categories defined, according their characteristics. most category laser handpieces, relate 21% all devices, while 28% not described. Studies cognitive function physiological characterisation are well defined ones with more tangible results. There is a lack consistency when reporting PBM studies, several articles under defining stimulation protocol, wide variety same health conditions (e.g., Alzheimer’s or Parkinson’s disease) resulting positive outcomes. Standardization report these warranted, as sham-controlled comparative have greatest effect on treatments different neurological conditions.
Language: Английский
Citations
8
Neurophotonics, Journal Year: 2024, Volume and Issue: 11(01)
Published: Feb. 5, 2024
The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood–brain barrier, limiting drug delivery to central nervous system (CNS). Transcranial photobiomodulation (tPBM) a promising technology treating diseases, due its effectiveness, non-invasiveness, and affordability. tPBM has been widely used in pre-clinical experiments clinical trials such as stroke Alzheimer's disease. This review provides comprehensive overview tPBM. We summarize emerging trends new discoveries based on over one hundred references published past 20 years. discuss advantages disadvantages highlight successful experimental protocols various A better understanding mechanisms, development guidelines practice, study dose-dependent personal effects hold great promise progress
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 3, 2024
Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005-0.02 Hz), neurogenic (N; 0.02-0.04 and myogenic (M; 0.04-0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive (PFC). Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.
Language: Английский
Citations
4
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
A non-invasive device to measure the dynamics of cerebrospinal fluid (CSF) is highly desirable because CSF facilitates cleaning neurotoxic wastes in brain. better understanding helps promote healthy aging older adults and treat patients with neurological diseases. This study employed a multi-color optical method quantify prefrontal two groups: (1) (n = 16) without 27) Alzheimer's disease (2) young 26) before after light stimulation. The results revealed that coupling strengths between cerebral blood volume (CBV) were age-dependent significantly higher AD than controls. Prefrontal stimulation enhanced CBV-CSF coupling, suggesting improved drainage. underscores strategy as unique tool for monitoring interaction CBV CSF, well metabolic functions human brain, while demonstrating therapeutic potential brain treating neurodegenerative diseases involving drainage dysfunction.
Language: Английский
Citations
0
Journal of Neural Engineering, Journal Year: 2022, Volume and Issue: 19(6), P. 066013 - 066013
Published: Nov. 1, 2022
Objective.Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and patients with Alzheimer's disease. In this study, we aimed to identify key cortical regions that present significant changes caused by tPBM the electroencephalogram (EEG) oscillation powers functional connectivity human brain.Approach. A 64-channel EEG was recorded from 45 participants during a 13 min period consisting of 2 baseline, 8 tPBM/sham intervention, 3 recovery. After pre-processing normalizing data at five rhythms, cluster-based permutation tests were performed for multiple comparisons spectral power topographies, followed graph-theory analysis as topological approach quantification brain metrics global nodal/cluster levels.Main results. enhancement observed clusters channels over frontoparietal alpha band centroparietal beta band. The measures network revealed reduction synchronization, efficiency, small-worldness connectivity, implying an complexity. addition, band, nodal graphical demonstrated increases local information integration centrality frontal clusters, accompanied decrease segregation bilateral frontal, left parietal, occipital regions.Significance.Frontal increased frontal-central-parietal regions, enhanced complexity beta-wave network, augmented flow oscillations across prefrontal regions. This study sheds light on potential link between electrophysiological effects improvement induced tPBM.
Language: Английский
Citations
15
Neurophotonics, Journal Year: 2023, Volume and Issue: 10(02)
Published: June 5, 2023
Transcranial photobiomodulation (tPBM) is a noninvasive neuromodulation method that facilitates the improvement of human cognition. However, limited information available in literature on wavelength- and site-specific effects prefrontal tPBM. Moreover, 2-channel broadband near-infrared spectroscopy (2-bbNIRS) new approach for quantifying infra-slow oscillations (ISO; 0.005 to 0.2 Hz) neurophysiological networks resting brain vivo.We aim prove hypothesis hemodynamic metabolic activities cortex are significantly modulated by tPBM modulation different ISO bands.Noninvasive 8-min with an 800- or 850-nm laser sham was delivered either side forehead 26 healthy young adults. A 2-bbNIRS unit used record activity 7 min before after tPBM/sham. The measured time series were analyzed frequency domain determine coherence at each three bands. Sham-controlled values represent tPBM-induced networks.Prefrontal wavelength lateral (1) increased ipsilateral metabolic-hemodynamic coupling endogenic band (2) desynchronized bilateral metabolism neurogenic vascular smooth-muscle hemodynamics myogenic band. Site-specific also observed significant enhancement connectivity right 800-nm tPBM.Prefrontal can modulate bilaterally unilaterally cortex. Such site- wavelength-specific
Language: Английский
Citations
7
Photonics, Journal Year: 2024, Volume and Issue: 11(8), P. 761 - 761
Published: Aug. 15, 2024
Bipolar disorder (BD) is a debilitating psychiatric characterized by mood disturbances and executive function deficits. Impairments in function, including impulsivity, significantly impact the daily lives of individuals with BD. Transcranial photobiomodulation (t-PBM) near-infrared light offers promising noninvasive neurostimulation approach to improve cognitive function. The Photobiomodulation for Executive Function Disorder (TPEB) study aims explore potential t-PBM BD impairments. This will include 20 adults who each receive one sham session on first day stimulation (treatment 1), followed four days 2 5). Cerebral blood flow changes be evaluated using functional magnetic resonance imaging. Impulsivity, decision-making, reward responsiveness assessed Barratt Impulsiveness Scale, Iowa Gambling Task, gambling task that evaluates reward. outcomes involve examining cerebral flow, improvements reductions impulsivity manic symptoms. TPEB provide valuable insights into as therapeutic intervention enhance
Language: Английский
Citations
2