Movement-Related Modulation in Mouse Auditory Cortex Is Widespread Yet Locally Diverse

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(11), P. e1227232024 - e1227232024

Published: Jan. 29, 2024

Neurons in the mouse auditory cortex are strongly influenced by behavior, including both suppression and enhancement of sound-evoked responses during movement. The comprises multiple fields with different roles sound processing distinct connectivity to movement-related centers brain. Here, we asked whether modulation male mice might differ across cortical fields, thereby contributing heterogeneity at single-cell level. We used wide-field calcium imaging identify cellular-resolution two-photon visualize activity layer 2/3 excitatory neurons within each field. measured neuron's three categories (pure tones, chirps, amplitude-modulated white noise) as rested ran on a non-motorized treadmill. found that individual field typically respond just one category. Some only active rest others locomotion, those responsive conditions retain their sound-category tuning. effects locomotion vary level, neural responses, net modulatory effect is largely conserved fields. Movement-related also reflects more complex behavioral patterns, instantaneous running speed nonlocomotor movements such grooming postural adjustments, similar patterns seen all Our findings underscore complexity throughout indicate widespread phenomenon.

Language: Английский

---

Food intake enhances hippocampal sharp wave-ripples

Published: Jan. 27, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body's state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding-when need increases, if so, feeding-dependent modulation communicated other regions regulation-remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Language: Английский

---

Food intake enhances hippocampal sharp wave-ripples

Published: Jan. 27, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown influence peripheral glucose metabolism. However, whether SWRs enhanced by recent feeding–when need increases, if so, feeding-dependent modulation communicated other regions regulation, remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Language: Английский

---

Multimodal mismatch responses in mouse auditory cortex

Published: Jan. 28, 2025

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

---

Multimodal mismatch responses in mouse auditory cortex

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 10, 2025

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory cortex, we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor (AM) mismatches, they closely resemble visuomotor (VM) mismatch (V1). Finally, testing for cross modal AM coupling sound amplitude flow speed running, were amplified when paired with concurrent VM mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

---

Food intake enhances hippocampal sharp wave-ripples

eLife, Journal Year: 2025, Volume and Issue: 14

Published: April 14, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding—when need increases, if so, feeding-dependent modulation communicated other regions regulation—remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Language: Английский

---

Food intake enhances hippocampal sharp wave-ripples

Published: April 3, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding– when need increases, if so, feeding-dependent modulation communicated other regions regulation, remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Language: Английский

---

Auditory regulation of hippocampal locomotion circuits by a non-canonical reticular-limbic pathway

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Abstract The ability to rapidly detect and respond unexpected auditory stimuli is critical for adaptive behavior, especially during locomotion. Since movement suppresses cortical activity, it remains unclear how salient information influences locomotor circuits. In this work, using in vivo calcium imaging, electrophysiology, chemo- optogenetics, we investigate the path that relays loud broadband sounds dorsal hippocampus (dHPC) modulates theta oscillations. We demonstrate noise accelerates frequency decreases its power, effects mediated by entorhinal cortex (EC) medial septum (MS) inputs while independent of primary cortex. Activation cochlear nucleus (DCN) neurons projecting pontine reticular (PRN) mimics noise-driven hippocampal responses, supporting a brainstem-limbic processing route. Furthermore, selectively CA1 pyramidal neuron interneuron reflecting diverse circuit dynamics. Finally, stimulus increased coherence between dHPC prefrontal (mPFC), enhancing interregional synchronization. These results highlight mechanisms which DCN filters behaviorally relevant promoting acoustic motor integration locomotion, without direct influence

Language: Английский

---

Whisking and locomotion are jointly represented in superior colliculus neurons

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(4), P. e3003087 - e3003087

Published: April 7, 2025

Active sensation requires the brain to interpret external stimuli against an ongoing estimate of body position. While internal estimates position are often ascribed cerebral cortex, we examined midbrain superior colliculus (SC), due its close relationship with sensory periphery as well higher, motor-related regions. Using high-density electrophysiology and movement tracking, discovered that on-going kinematics whisker motion locomotion speed accurately predict firing rate mouse SC neurons. Neural activity was best predicted by movements occurring either in past, present, or future, indicating population continuously a trajectory self-motion. A combined representation slow fast whisking features absolute angle at high temporal resolution. Sensory reafference played least partial role shaping this feature tuning. Taken together, these data indicate contains joint locomotor is potentially useful guiding complex orienting involving face limbs.

Language: Английский

---

Multimodal mismatch responses in mouse auditory cortex

Published: March 22, 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

---