Food Webs and Feedbacks: The Untold Ecological Relevance of Antimicrobial Resistance as Seen in Harmful Algal Blooms DOI Creative Commons
Aabir Banerji, Nichole E. Brinkman, Benjamin C. Davis

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2121 - 2121

Published: Oct. 23, 2024

Antimicrobial resistance (AMR) has long been framed as an epidemiological and public health concern. Its impacts on the environment are unclear. Yet, basis for AMR is altered cell physiology. Just this affects how microbes interact with antimicrobials, it can also affect they their own species, other non-living environment. Moreover, if globally notorious causing landscape-level environmental issues, then these effects could alter biodiversity ecosystem function a grand scale. To investigate possibilities, we compiled peer-reviewed literature from past 20 years regarding in toxic freshwater cyanobacterial harmful algal blooms (HABs). We examined evidence of affecting HAB frequency, severity, or persistence. Although no study within our scope was explicitly designed to address question, multiple studies reported AMR-associated changes HAB-forming cyanobacteria (and co-occurring microbes) that pertained directly timing, toxicity, phase, well dynamics HAB-afflicted aquatic food webs. These findings highlight potential have far-reaching (including loss function) bring into focus importance confronting complex interrelated issues such HABs concert, interdisciplinary tools perspectives.

Language: Английский

Evolution and ecology of anti-defence systems in phages and plasmids DOI Creative Commons
Théophile Niault, Stineke van Houte, Edze R. Westra

et al.

Current Biology, Journal Year: 2025, Volume and Issue: 35(1), P. R32 - R44

Published: Jan. 1, 2025

Language: Английский

Citations

3
Virological and Pharmaceutical Properties of Clinically Relevant Phages DOI Creative Commons

Antonios-Periklis Panagiotopoulos,

Antonia P. Sagona,

Deny Tsakri

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 487 - 487

Published: May 10, 2025

As antimicrobial resistance continues to undermine the efficacy of antibiotics, global medical community is increasingly turning alternative treatment modalities. Among these, phage therapy has re-emerged as a promising strategy for managing multidrug-resistant bacterial infections. Herein, we present and briefly discuss eight essential attributes clinically relevant phages therapy, which may be categorized broadly into virological pharmacological characteristics. Virological include broad host range, strictly lytic life cycle ability manage emergence phages. Comprehensive genomic proteomic characterization forms foundation selecting engineering such candidates, ensuring both safety predictability. From standpoint, should ideally show across formulations routes administration, favorable pharmacokinetics, stability during storage scalability in manufacturing. Advances analysis, artificial intelligence-driven selection formulation technologies have further accelerated translational potential therapy. By systematically addressing each these critical attributes, this work aims inform rational development therapeutic suitable integration clinical practice.

Language: Английский

Citations

0
The Prospect and Challenge of Bacteriophages for Biocontrol in Food Industry DOI

Junxin Zhao,

Fugang Xiao,

Jingyi Gui

et al.

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: May 20, 2025

Language: Английский

Citations

0
Overview of Phage Defense Systems in Bacteria and Their Applications DOI Open Access

Xiaomei Xu,

Pengfei Gu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13316 - 13316

Published: Dec. 12, 2024

As natural parasites of bacteria, phages have greatly contributed to bacterial evolution owing their persistent threat. Diverse phage resistance systems been developed in bacteria during the coevolutionary process with phages. Conversely, contamination has a devastating effect on microbial fermentation, resulting fermentation failure and substantial economic loss. Accordingly, defense derived from can be employed obtain robust phage-resistant host cells that overcome threats posed by bacteriophages industrial processes. In this review, diverse mechanisms, including remarkable research progress potential applications, are systematically summarized. addition, development prospects challenges discussed. This review provides useful reference for developing bacteria.

Language: Английский

Citations

2
Biological warfare between two bacterial viruses in a defense archipelago sheds light on the spread of CRISPR-Cas systems DOI Creative Commons
Alejandro Rubio, Andrés Garzón, Antonio Moreno-Rodríguez

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(12), P. 115085 - 115085

Published: Dec. 1, 2024

Language: Английский

Citations

2
Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs DOI Creative Commons
Meaghan Castledine, Daniel Padfield, M. Corrie Schoeman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract Bacteriophages can be important drivers of bacterial densities, and therefore microbial community composition function. These ecological interactions are likely to greatly affected by evolutionary dynamics, because bacteria rapidly evolve resistance phage while reciprocally increase infectivity. Most studies date have explored eco-evolutionary dynamics using isolated pairs bacteria-phage but in nature, multiple phages coexist (co)evolve simultaneously. How coevolution plays out this context is poorly understood. Here, we examine how three coexisting soil ( Ochrobactrum sp., Pseudomonas Variovorax sp.) interact with species-specific bacteriophages over eight weeks experimental evolution, both as host-parasite isolation a mixed community. Across all species evolution was inhibited polyculture, the most pronounced effect on . Between there were also substantial differences host including whether coevolved. contrasts emphasise difficulty generalising from monoculture between wider systems. Future should consider simultaneously better understand coevolutionary happen natural communities. Importance This project unique examining among their phages, rather than focus single focal – makes our work more applicable contexts still working controlled synthetic While it commonly assumed that will coevolve phage, may uncommon complex communities due reduced contact rates and/or mutation rates. Furthermore, contrast population ability highlights need for studied. Over-reliance model systems known means lack an understanding interact, what extent results generalised beyond these pairs.

Language: Английский

Citations

1
Food Webs and Feedbacks: The Untold Ecological Relevance of Antimicrobial Resistance as Seen in Harmful Algal Blooms DOI Creative Commons
Aabir Banerji, Nichole E. Brinkman, Benjamin C. Davis

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2121 - 2121

Published: Oct. 23, 2024

Antimicrobial resistance (AMR) has long been framed as an epidemiological and public health concern. Its impacts on the environment are unclear. Yet, basis for AMR is altered cell physiology. Just this affects how microbes interact with antimicrobials, it can also affect they their own species, other non-living environment. Moreover, if globally notorious causing landscape-level environmental issues, then these effects could alter biodiversity ecosystem function a grand scale. To investigate possibilities, we compiled peer-reviewed literature from past 20 years regarding in toxic freshwater cyanobacterial harmful algal blooms (HABs). We examined evidence of affecting HAB frequency, severity, or persistence. Although no study within our scope was explicitly designed to address question, multiple studies reported AMR-associated changes HAB-forming cyanobacteria (and co-occurring microbes) that pertained directly timing, toxicity, phase, well dynamics HAB-afflicted aquatic food webs. These findings highlight potential have far-reaching (including loss function) bring into focus importance confronting complex interrelated issues such HABs concert, interdisciplinary tools perspectives.

Language: Английский

Citations

0