Nutrients,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2451 - 2451
Published: May 24, 2023
The
microbial
cells
colonizing
the
human
body
form
an
ecosystem
that
is
integral
to
regulation
and
maintenance
of
health.
Elucidation
specific
associations
between
microbiome
health
outcomes
facilitating
development
microbiome-targeted
recommendations
treatments
(e.g.,
fecal
microbiota
transplant;
pre-,
pro-,
post-biotics)
help
prevent
treat
disease.
However,
potential
such
improve
has
yet
be
fully
realized.
Technological
advances
have
led
proliferation
a
wide
range
tools
methods
collect,
store,
sequence,
analyze
samples.
differences
in
methodology
at
each
step
these
analytic
processes
can
lead
variability
results
due
unique
biases
limitations
component.
This
technical
hampers
detection
validation
with
small
medium
effect
sizes.
Therefore,
American
Society
for
Nutrition
(ASN)
Nutritional
Microbiology
Group
Engaging
Members
(GEM),
sponsored
by
Institute
Advancement
Food
Sciences
(IAFNS),
hosted
satellite
session
on
nutrition
gut
research
review
currently
available
research,
best
practices,
as
well
standards
aid
comparability
results.
manuscript
summarizes
topics
discussed
session.
Consideration
guidelines
principles
reviewed
this
will
increase
accuracy,
precision,
ultimately
understanding
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 11, 2024
Clinical
studies
of
the
urinary
tract
microbiome,
termed
urobiome,
suggest
a
direct,
antibiotic-dependent,
impact
urobiome
on
kidney
physiology.
However,
evidence
for
bacteria
comes
from
indirect
sources
or
infected
tissue.
Further,
it
is
unclear
how
antibiotics
bacteria.
Here
we
show
direct
presence
in
kidneys,
with
microniches
nephrons.
In
murine
administration
cefazolin,
commonly
used
perioperative
antibiotic,
led
to
loss
uroprotective
Lactobacillus
spp.
and
proliferation
Enterobacteriaceae
(which
includes
many
known
uropathogens).
This
effect
was
dependent
treatment
duration,
recovery
post
treatment.
Uroprotective
L.
crispatus
strain
stone-associated
E.
coli
differentially
influenced
calcium
oxalate
(CaOx)
crystallization
through
incorporation
CaOx
inhibitors
promoters,
respectively.
humans,
microbial
signatures
were
identified
kidney,
unique
niches
between
glomeruli
tubules,
established
RNA
sequencing
analysis
imaging
two
independent
populations.
Collectively,
findings
support
hypothesis
that
kidneys
harbor
stable
antibiotic-responsive
microbiota
can
influence
lithogenesis.
The
unique,
age-dependent
tubuli
carry
implications
non-infectious
diseases.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Oct. 6, 2023
Abstract
The
outbreak
of
Coronavirus
disease
2019
(COVID-19),
caused
by
SARS-CoV-2,
forced
us
to
face
a
pandemic
with
unprecedented
social,
economic,
and
public
health
consequences.
Several
nations
have
launched
campaigns
immunize
millions
people
using
various
vaccines
prevent
infections.
Meanwhile,
therapeutic
approaches
discoveries
continuously
arise;
however,
identifying
infected
patients
that
are
going
experience
the
more
severe
outcomes
COVID-19
is
still
major
need,
focus
efforts,
reducing
hospitalization
mitigating
drug
adverse
effects.
Microbial
communities
colonizing
respiratory
tract
exert
significant
effects
on
host
immune
responses,
influencing
susceptibility
infectious
agents.
Through
16S
rDNAseq
we
characterized
upper
airways’
microbiota
192
subjects
nasopharyngeal
swab
positive
for
SARS-CoV-2.
Patients
were
divided
into
groups
based
presence
symptoms,
pneumonia
severity,
need
oxygen
therapy
or
intubation.
Indeed,
unlike
most
literature,
our
study
focuses
microbial
signatures
predictive
progression
rather
than
probability
infection
itself,
which
consensus
lacking.
Diversity,
differential
abundance,
network
analysis
at
different
taxonomic
levels
synergistically
adopted,
in
robust
bioinformatic
pipeline,
highlighting
novel
possible
taxa
correlated
patients’
AIDS,
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 12, 2023
The
perturbation
of
tryptophan
(TRP)
metabolism
has
been
linked
with
HIV
infection
and
cardiovascular
disease
(CVD),
but
the
interrelationship
among
TRP
metabolites,
gut
microbiota,
atherosclerosis
remain
unclear
in
context
infection.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2451 - 2451
Published: May 24, 2023
The
microbial
cells
colonizing
the
human
body
form
an
ecosystem
that
is
integral
to
regulation
and
maintenance
of
health.
Elucidation
specific
associations
between
microbiome
health
outcomes
facilitating
development
microbiome-targeted
recommendations
treatments
(e.g.,
fecal
microbiota
transplant;
pre-,
pro-,
post-biotics)
help
prevent
treat
disease.
However,
potential
such
improve
has
yet
be
fully
realized.
Technological
advances
have
led
proliferation
a
wide
range
tools
methods
collect,
store,
sequence,
analyze
samples.
differences
in
methodology
at
each
step
these
analytic
processes
can
lead
variability
results
due
unique
biases
limitations
component.
This
technical
hampers
detection
validation
with
small
medium
effect
sizes.
Therefore,
American
Society
for
Nutrition
(ASN)
Nutritional
Microbiology
Group
Engaging
Members
(GEM),
sponsored
by
Institute
Advancement
Food
Sciences
(IAFNS),
hosted
satellite
session
on
nutrition
gut
research
review
currently
available
research,
best
practices,
as
well
standards
aid
comparability
results.
manuscript
summarizes
topics
discussed
session.
Consideration
guidelines
principles
reviewed
this
will
increase
accuracy,
precision,
ultimately
understanding
