Circadian rhythms, metabolism, and nutrition support in critically ill adult patients: a narrative review DOI
Yu‐Hsiang Chiu, Anushka Sharma, Hassan S. Dashti

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Purpose of review The human circadian system regulates several physiological processes, including metabolism, which becomes significantly disrupted during critical illness. common use 24-h continuous nutrition support feeding in the intensive care unit (ICU) may further exacerbate these disruptions; this evaluates recent evidence comparing and intermittent schedules critically ill adults. Recent findings Research different adults remains limited. meta-analyses suggest that ICU have comparable adverse event profiles, gastrointestinal intolerance. A retrospective study found did not impact glucose variation adults, a randomized controlled trial reported no significant differences amino acid, lipid-based, or small molecule metabolite profiles between two regimens. Potential benefits include stimulation muscle protein synthesis, preservation normal hormone secretion, improved attainment nutritional goals. Summary Current suggests safety for adult patients. However, daytime cyclic are expected to align more closely with physiology. Given lack existing supportive data, dynamic approach – transitioning from early-acute metabolic phase be appropriate.

Language: Английский

Wearables in Chronomedicine and Interpretation of Circadian Health DOI Creative Commons
Denis Gubin,

Dietmar Weinert,

Oliver Stefani

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 327 - 327

Published: Jan. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Language: Английский

Citations

2
Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death. DOI Creative Commons
Nadim El Jamal, Thomas G. Brooks,

Antonijo Mrčela

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Background The ICU environment is disruptive to a patient’s biological rhythms where sleep-wake cycles are often desynchronized from the environmental day-night changes. This puts patients at increased risk develop delirium with consequent fiscal pressure for health care system. An underappreciated dimension how time-specific patient phenotypes in critical relate clinical outcomes. We set out analyze rhythmic components (or lack thereof) physiological data streams sampled high resolution were associated future incidence of and death. To offer cues further interrogation into mechanism prognosis, we examined differences 24-hour fluctuations labs populations risk. Methods Rhythmic using dipping ratios JTK_CYCLE statistics derived blood heart rate measurements available admissions recorded MIMIC IV database. Logistic adjusted regression models assessed association between disrupted vital sign during same hospital admission Aggregation numeric lab across first 24 hours all allowed modelling patterns subsequent studies link potential biochemical mechanisms perturbed adverse Results Patients reverse 40% higher have diagnosis (Odds Ratio: 1.40, 95% CI: 1.14-1.72) 13% death 1.13, 1.02-1.26). Compared population nocturnal dip, dippers showed biochemistry profiles suggestive altered circadian programs specifically parameters renal, metabolic, hemostatic function. Conclusions Reverse can be an early development accompanied by biorhythms multiple organ systems. Dampened reversed patients. Considering inclusion these factors preventive may improve outcomes reduce burden on

Language: Английский

Citations

0
Daily variation in blood glucose levels during continuous enteral nutrition in patients on the intensive care unit: a retrospective observational study DOI Creative Commons
Floor W Hiemstra, Dirk Jan Stenvers, Andries Kalsbeek

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 104, P. 105169 - 105169

Published: May 30, 2024

The circadian timing system coordinates daily cycles in physiological functions, including glucose metabolism and insulin sensitivity. Here, the aim was to characterise 24-h variation levels critically ill patients during continuous enteral nutrition after controlling for potential sources of bias.

Language: Английский

Citations

3
Circadian rhythms, metabolism, and nutrition support in critically ill adult patients: a narrative review DOI
Yu‐Hsiang Chiu, Anushka Sharma, Hassan S. Dashti

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Purpose of review The human circadian system regulates several physiological processes, including metabolism, which becomes significantly disrupted during critical illness. common use 24-h continuous nutrition support feeding in the intensive care unit (ICU) may further exacerbate these disruptions; this evaluates recent evidence comparing and intermittent schedules critically ill adults. Recent findings Research different adults remains limited. meta-analyses suggest that ICU have comparable adverse event profiles, gastrointestinal intolerance. A retrospective study found did not impact glucose variation adults, a randomized controlled trial reported no significant differences amino acid, lipid-based, or small molecule metabolite profiles between two regimens. Potential benefits include stimulation muscle protein synthesis, preservation normal hormone secretion, improved attainment nutritional goals. Summary Current suggests safety for adult patients. However, daytime cyclic are expected to align more closely with physiology. Given lack existing supportive data, dynamic approach – transitioning from early-acute metabolic phase be appropriate.

Language: Английский

Citations

0