Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2—A Candidate for Passive Immunization against COVID-19 DOI Creative Commons
Hendris Wongso, I Nyoman Bayu Mahendra, Wyanda Arnafia

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(1), P. 128 - 128

Published: Jan. 17, 2022

The coronavirus disease 2019 (COVID-19) has become a substantial threat to the international health sector and global economy. As of 26 December 2021, number mortalities resulting from COVID-19 exceeded 5.3 million worldwide. absence an effective non-vaccine treatment prompted quest for prophylactic agents that can be used combat COVID-19. This study presents feasibility chicken egg yolk antibody (IgY) anti-receptor-binding domain (RBD) spike SARS-CoV-2 as strong candidate neutralize virus application in passive immunization. For purpose preclinical studies, we radiolabeled IgY anti-RBD with radionuclide iodine-131. allowed us evaluate several biological characteristics vitro, vivo, ex vivo. data suggest could specifically bind antigens; however, little uptake was observed normal cells (MRC-5) (<2%). Furthermore, vivo biodistribution revealed predominantly accumulated trachea mice compared other organs. We also found possessed good safety profile when intranasal agent. Taken together, propose potential immunization against

Language: Английский

Predictors of Fatigue Progression in Long COVID Among Young People DOI Creative Commons

Elias Myrstad Brodwall,

Joel Selvakumar, Lise Beier Havdal

et al.

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: unknown, P. 100982 - 100982

Published: March 1, 2025

Language: Английский

Citations

0
The importance of playing the long game when it comes to pandemic surveillance DOI Creative Commons
Freya M. Shearer, Marc Lipsitch

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(15)

Published: April 9, 2025

Language: Английский

Citations

0
Habitual adherence to a traditional Mediterranean diet and risk of SARS-CoV-2 infection and Coronavirus disease 2019 (COVID-19): a longitudinal analysis DOI
Sukshma Sharma, Augusto Di Castelnuovo, Simona Costanzo

et al.

International Journal of Food Sciences and Nutrition, Journal Year: 2023, Volume and Issue: 74(3), P. 382 - 394

Published: April 3, 2023

Evidence on habitual Mediterranean diet (MD) and risk of SARS-CoV-2 infection, COVID-19 is limited. 1,520 participants from the Moli-sani Study (2017-2020) were tested during January-September 2021 adherence to MD was ascertained through Diet Score (MDS). infection cases determined serology, previous clinical diagnosis disease self-reported. Results presented as odd ratios (OR) with 95% confidence intervals (CI). The MDS not associated likelihood (OR= 0.94; CI: 0.83-1.06) 0.82; 0.62-1.10) diagnosis. High consumption cereals lower odds (OR = 0.91; 0.83-1.00; for each 25 g/d increase). Likelihood having being diagnosed decreased in association increasing olive oil intake 0.10; 0.01-0.79; additional 10 g/d), moderate alcohol 0.18; 0.04-0.82) higher intakes fruits nuts 0.89; 0.79-0.99). Our findings emphasise adoption maintenance a balanced key strategy reduce future infections COVID-19.

Language: Английский

Citations

10
The predictive role of symptoms in COVID-19 diagnostic models: A longitudinal insight DOI Creative Commons
Olivia Bird, Eva Galiza,

D. N. Baxter

et al.

Epidemiology and Infection, Journal Year: 2024, Volume and Issue: 152

Published: Jan. 1, 2024

Abstract To investigate the symptoms of SARS-CoV-2 infection, their dynamics and discriminatory power for disease using longitudinally, prospectively collected information reported at time occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was predominant strain. Participants were assessed infection via nasal/throat PCR recruitment, vaccination appointments, when symptomatic. Statistical techniques implemented to infer estimates representative population, accounting multiple symptomatic episodes associated with one individual. An optimal diagnostic model derived. 4-month prevalence 2.1%; increasing 19.4% (16.0%–22.7%) in participants reporting loss appetite 31.9% (27.1%–36.8%) those anosmia/ageusia. identified anosmia and/or ageusia, fever, congestion, cough be significantly infection. Symptoms’ vastly different two groups; after slow start peaking later lasting longer PCR+ participants, whilst exhibiting consistent decline PCR- with, on average, fewer than days reported. Anosmia/ageusia peaked late confirmed (day 12), indicating low discrimination early diagnosis.

Language: Английский

Citations

3
Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2—A Candidate for Passive Immunization against COVID-19 DOI Creative Commons
Hendris Wongso, I Nyoman Bayu Mahendra, Wyanda Arnafia

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(1), P. 128 - 128

Published: Jan. 17, 2022

The coronavirus disease 2019 (COVID-19) has become a substantial threat to the international health sector and global economy. As of 26 December 2021, number mortalities resulting from COVID-19 exceeded 5.3 million worldwide. absence an effective non-vaccine treatment prompted quest for prophylactic agents that can be used combat COVID-19. This study presents feasibility chicken egg yolk antibody (IgY) anti-receptor-binding domain (RBD) spike SARS-CoV-2 as strong candidate neutralize virus application in passive immunization. For purpose preclinical studies, we radiolabeled IgY anti-RBD with radionuclide iodine-131. allowed us evaluate several biological characteristics vitro, vivo, ex vivo. data suggest could specifically bind antigens; however, little uptake was observed normal cells (MRC-5) (<2%). Furthermore, vivo biodistribution revealed predominantly accumulated trachea mice compared other organs. We also found possessed good safety profile when intranasal agent. Taken together, propose potential immunization against

Language: Английский

Citations

16