Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

The Lancet, Journal Year: 2024, Volume and Issue: 404(10452), P. 572 - 628

Published: July 31, 2024

Language: Английский

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The Role of Nutrition and Other Lifestyle Patterns in Mortality Risk in Older Adults with Multimorbidity

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 796 - 796

Published: Feb. 25, 2025

Background: Limited research has examined how older adults' lifestyles intersect with multimorbidity to influence mortality risk. Methods: In this community-dwelling prospective cohort, the Sydney Memory and Ageing Study, principal component analysis was used identify lifestyle patterns using baseline self-reported data on nutrition, factors, social engagement activities. Multimorbidity defined by physician diagnoses. Multivariable logistic regression estimate odds ratios (ORs) for cross-sectionally, Cox proportional hazards models were assess hazard (HRs) risk longitudinally. Results: Of 895 participants (mean age: 78.2 years; 56.3% female) complete data, 597 had multimorbidity. Two distinct emerged: (i) a nutrition pattern characterised higher intakes of protein, fibre, iron, zinc, magnesium, potassium, folate, (ii) an exercise-sleep-social marked weekly physical activities like bowling, bicycling, sleep quality (low snoring/sleepiness), high engagement. Neither associated cross-sectionally. Over median 5.8-year follow-up (n = 869; 140 deaths), in upper tertiles combined scores 20% lower than those lowest tertile [adjusted HR: 0.80 (95% CI: 0.65-0.97); p-trend 0.02]. This association stronger multimorbidity, 29% [0.71 (0.56-0.89); 0.01], likely due modifying relationship between (p-interaction < 0.05). While did not modify mortality, it consistently 19-20% (p-trend 0.03), regardless status. Conclusions: Older adults may particularly benefit from adopting healthy focusing activity, quality, reduce their

Language: Английский

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Determinants of Multimorbidity in a Low‐Resource Setting: A Population‐Based Cross‐Sectional Study in Bangladesh

Global Health, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Multimorbidity is a complex and highly prevalent health condition characterised by the coexistence of two or more chronic diseases within an individual. It growing public issue worldwide, predominantly in low-resource countries like Bangladesh. Therefore, this study aimed to determine prevalence associated factors multimorbidity among adult population A cross-sectional was carried out 504 respondents who were 18 years older. The generalised linear mixed model used identify risk factors. Among respondents, 65.3% (95% confidence interval [CI]: 61.0 69.3) had multimorbidity. most common conditions allergic disorder (34%, 95% CI: 30 39), gastritis (31%, 27 35), low back pain (28.4%, 24.6 32.5), oral (27%, 23 29) arthritis (21%, 25). Middle-aged adults (adjusted odds ratio [AOR] = 7.97; 3.35 18.92) older (AOR 8.44; 1.90 36.64) significantly higher than young adults. Employed 86% 0.14; 0.07 0.36) lower non-working individuals. Higher sleeping duration (6 8 h: AOR 0.44; 0.25 0.80; 10 0.26; 0.11 0.60), regular vegetable consumption 0.42; 0.22 0.80) adequate water intake 0.48; 0.29 0.79) protective against multimorbidity, whereas obesity increased 3.32; 1.06 10.43). These findings emphasise need promote healthy lifestyle habits, such as maintaining balanced diet, staying hydrated engaging physical exercise, reduce burden settings.

Language: Английский

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Association between sleep traits and primary liver cancer: A Mendelian randomization analysis

European Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 53(8)

Published: April 8, 2023

Primary liver cancer (PLC) is the sixth most frequently occurring cancer, representing one of top 5 leading causes cancer-related mortality worldwide. Recently, researchers have focused more on impact living habits incidence and development tumours. This study reports a relationship between sleep traits PLC.In this study, we used published genome-wide association studies to obtain exposure factors 6 traits. Mendelian randomization (MR) analysis was assess causal PLC via inverse-variance weighted (IVW), MR Egger median. Sensitivity reduce bias.Our investigation revealed that there negative correlation duration group bile duct by IVW (p-value = .042), result similarly observed in cell carcinoma Weighted Median .026). In contrast, positive found napping during day primary cohorts .030), .043) malignant neoplasm other unspecified parts biliary tract .016) IVW. Furthermore, our also insomnia intrahepatic ducts .022).Overall, indicates nap may be risk adequate night might keep us away from PLC.

Language: Английский

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The relationship between sleep health and multimorbidity in community dwelling populations: Systematic review and global perspectives

Sleep Medicine, Journal Year: 2023, Volume and Issue: 109, P. 270 - 284

Published: July 14, 2023

Language: Английский

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Trajectories of sleep duration and quality and their association with mild cognitive impairment, frailty, and all-cause mortality

Sleep Health, Journal Year: 2024, Volume and Issue: 10(2), P. 240 - 248

Published: Jan. 21, 2024

Language: Английский

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Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 27, 2024

Atypical temporal work patterns such as working longer than the standard 35-40 h/ week, weekend working, and nonstandard schedules (i.e. outside of typical 9-5, including but not restricted to shiftwork) are increasingly prevalent in UK. Aside from occupation-specific studies, little is known about effects these atypical on sleep among workers UK, even though poor has been linked adverse health problems, lower workplace productivity, economic costs.

Language: Английский

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Multiple geriatric syndromes in community-dwelling older adults in China

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 12, 2024

Abstract This study aims to assess the prevalence of geriatric syndromes and identify factors associated with multiple in community-dwelling older adults China. We utilized a convenience sampling method recruit from one rural urban community Chengdu, China, October 2022 March 2023. A total 706 aged 60 years or were included. Ten investigated including two mental disorders: depressive symptoms, cognitive impairment; eight somatic pain, falls, sleep disturbance, constipation, polypharmacy, multimorbidity, malnutrition frailty. Multiple defined as an individual having more syndromes. The data obtained analysed using descriptive statistics. independent risk for assessed logistic regression model. found that 90.5% participants had at least syndrome, 72.8% experiencing top four our polypharmacy (58.5%), malnutrition/at (43.1%), multimorbidity (42.1%), frailty/prefrailty (34.3%). Of adults, 368(52.1%) only disorders, 18(2.5%) disorders 253 (35.8%) somatic-mental disorders. According analysis, residence, age, marriage, BMI, self-related health significantly among adults. highlights are prevalent underscores significance certain demographic their occurrence. Future longitudinal studies needed establish temporal relationship between these factors, well explore causal relationships effective prevention strategies syndrome.

Language: Английский

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Sleep deprivation detected by voice analysis

PLoS Computational Biology, Journal Year: 2024, Volume and Issue: 20(2), P. e1011849 - e1011849

Published: Feb. 5, 2024

Sleep deprivation has an ever-increasing impact on individuals and societies. Yet, to date, there is no quick objective test for sleep deprivation. Here, we used automated acoustic analyses of the voice detect Building current machine-learning approaches, focused interpretability by introducing two novel ideas: use a fully generic auditory representation as input feature space, combined with interpretation technique based reverse correlation. The consisted spectro-temporal modulation analysis derived from neurophysiology. method aimed reveal regions that supported classifiers' decisions. Results showed features could be successfully, accuracy comparable state-of-the-art speech features. Furthermore, revealed distinct effects voice: changes in slow temporal modulations related prosody spectral quality. Importantly, relative balance varied widely across individuals, even though amount was controlled, thus confirming need characterize at individual level. Moreover, while factor correlated subjective sleepiness reports, quality did not, consistent presence both explicit implicit consequences Overall, findings show may observed vocal biomarkers. Future investigations correlating such markers physiological measures enable "sleep stethoscopes" cost-effective diagnosis

Language: Английский

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Heatwave exposure in relation to decreased sleep duration in older adults

Environment International, Journal Year: 2023, Volume and Issue: 183, P. 108348 - 108348

Published: Nov. 23, 2023

Few studies have delved into the effects of heatwaves on sleep duration loss among older adults. Our study examined correlations between heatwave exposure and reductions in this demographic. Utilizing data 7,240 adults drawn from China Health Retirement Longitudinal Study (CHARLS) 2015 to 2018, we assessed differences baseline year (2015) follow-up (2018). Absolute were defined as ≥1, 1.5, or 2 hours. Changes categorized based cut-offs 5 8 hours, including excessive decrease, moderate short persistent types. 12 definitions combining four thresholds (90th, 92.5th, 95th, 97.5th percentiles daily minimum temperature) three durations (≥2, ≥3 ≥4 days) used. Heatwave was determined by difference number preceding months' days events 2018. The results showed that increased (defined ≥ P90th percentile & lasting associated with a higher likelihood ≥1-hour reduction duration. An increase event P95th linked shifts For association an absolute exposure, while signified greater risks, effect estimates longer not uniformly consistent. We observed air pollution green space modified relationship Females, urban residents, individuals chronic diseases identified vulnerable populations. This found risk

Language: Английский

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