Relationship Between Schizophrenia and Sepsis : Evidence from two- sample mendelian randomization DOI Creative Commons
Songtao Liu, Lixia Mao, Yongxia Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 8, 2024

Abstract Background Observational research in its early stages has identified a potential correlation between schizophrenia and an escalated risk of sepsis patients.Inferring causal effects from observational studies is challenging due to the for confounding variables influence any associations.Two sample Mendelian randomization(MR)is method evaluating relationships that utilizes genetic variation as instrumental variable, which can reduce bias traditional studies. Method We selected single nucleotide polymorphisms (SNPs) associated with Large GenomeAssociation Study(GWAS).Using two MR analysis,we evaluated theassociation these SNPs estimate potentialcausal impact on sepsis. Result Our study uncovered no conditions. The analysis indicated minimal support causative link increased (OR = 1.00416, p 0.837). Sensitivity analyses yielded consistent results, underscoring causality's reliability. Additionally, we observed heterogeneity or pleiotropic bias. Conclusion There currently insufficient evidence direct causalrelationship schizophrenia.

Language: Английский

Impact of Antimicrobial Stewardship on Reducing Antimicrobial Resistance DOI Open Access

Sagar N Khadse,

Sarita Ugemuge, Charu Singh

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Antimicrobial resistance has become a serious global issue, posing significant threat to public health and healthcare professionals. Since the advent of penicillin, many antibiotics have lost their effectiveness in combating microbes simply due inappropriate, irrational, unnecessary, unrestricted use. The ineffectiveness an increasing number necessitates utilization more potent antimicrobial agents for combatting uncomplicated infections. In response escalating prevalence multidrug-resistant pathogens imperative curtail demand novel antibiotics, Stewardship Program was conceived implemented. This initiative is characterized by lead physician, ideally possessing expertise infectious diseases, alongside pharmacist serving as secondary leader microbiologist with defined responsibilities achieve several objectives. These objectives include reducing indiscriminate usage agents, promoting selective based on culture results, de-escalating therapy from broad-spectrum targeted transitioning parenteral oral administration when feasible. are pursued through combination pre-prescription post-prescription strategies. While widely established developed nations, pressing need exists its comprehensive implementation less regions. review aims examine strategies used stewardship programs evaluate preventing development organisms (MDROs) existing research studies. Under Program, education professionals continuous disposal information about helped restrict emergence organisms.

Language: Английский

Citations

27
Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study DOI Creative Commons
Tapio Paljärvi, Kimmo Herttua, Heidi Taipale

et al.

BMJ Mental Health, Journal Year: 2023, Volume and Issue: 26(1), P. e300700 - e300700

Published: May 1, 2023

Background Bipolar disorder (BD) is associated with increased mortality, but evidence on cause-specific mortality limited. Objective To investigate premature excess in BD. Methods Finnish nationwide cohort study of individuals and without a diagnosis BD who were aged 15–64 years during 2004–2018. Standardised ratios (SMRs) 95% CIs calculated for using the rates general population as weights. Causes death defined by International Classification Diseases, 10th revision codes. Findings Of included 47 018 BD, 3300 (7%) died follow-up. Individuals had sixfold higher due to external causes (SMR: 6.01, CI: 5.68, 6.34) twofold somatic 2.06, 1.97, 2.15). deaths causes, 83% (1061/1273) deaths, whereas 51% (1043/2027) excess. About twice number potential life lost than causes. Alcohol-related contributed more cardiovascular disease. Conclusion External gap after controlling age-specific background mortality. Clinical implication A balanced consideration between therapeutic response, different treatment options risk needed prevent reduce gap.

Language: Английский

Citations

11
Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland DOI Creative Commons
Dylan Flaws, Kyle White, Felicity Edwards

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

Language: Английский

Citations

0
Causal associations between severe mental illness and sepsis: a Mendelian randomization study DOI Creative Commons

Ruhao Yang,

Hongyu Xiang, Ting Zheng

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: March 12, 2024

Objective SMI (severe mental illness) has been identified as a risk factor for sepsis in observational studies; however, the causal association between them yet to be firmly established. We conducted MR (mendelian randomization) unveil relationship and well mortality. Methods GWAS (Genome-wide association) data major depression schizophrenia were selected exposure. mortality outcome. Genetic variants significantly associated with exposure ( P value<1x10 -6 ) instruments. primarily employed IVW (inverse-variance weighted) method analysis. Furthermore, we Cochrane’s Q test assess heterogeneity MR-Egger intercept identify horizontal pleiotropy. Results 108 SNPs (single nucleotide polymorphism) used predict 260 that predicted schizophrenia. Genetically was suggestively linked higher (OR=1.13, 95%CI 1.02-1.26, =0.023). In contrast, analysis did not find an (OR=1.00, 0.97-1.04, =0.811). no significant evidence found genetically Moreover, pleiotropy detected. Conclusion Our research revealed suggestive elevated of individuals European ancestry. This finding can serve reminder clinicians consider possibility subsequent infection depressive patients, which may help reduce incidence depression.

Language: Английский

Citations

3
Severe mental illness and infectious disease mortality: a systematic review and meta-analysis DOI Creative Commons
Amy Ronaldson,

Isabelle Nascimento Santana,

Sophie Carlisle

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 77, P. 102867 - 102867

Published: Oct. 9, 2024

Language: Английский

Citations

2
Antipsychotic use and 28-day mortality in patients hospitalized with COVID-19: A multicenter observational retrospective study DOI Creative Commons
Marina Sánchez‐Rico,

Alejandro Edán-Sánchez,

Mark Olfson

et al.

European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 75, P. 93 - 104

Published: June 16, 2023

Language: Английский

Citations

4
Association of mental disorders with sepsis: a bidirectional Mendelian randomization study DOI Creative Commons

Yuanzhi Hu,

Zihui Xiong,

Pinge Huang

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 17, 2024

Background Substantial research evidence supports the correlation between mental disorders and sepsis. Nevertheless, causal connection a particular psychological disorder sepsis remains unclear. Methods For investigating relationships sepsis, genetic variants correlated with disorders, including anorexia nervosa (AN), attention-deficit hyperactivity (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), panic (PD), posttraumatic stress (PTSD), schizophrenia (SCZ), tourette syndrome (TS), were all extracted from Psychiatric Genomics Consortium (PGC). The estimates direction these evaluated employing two-sample bidirectional MR strategy. inverse variance weighted (IVW) method was primary approach utilized. Various sensitivity analyses performed to confirm validity of effect. Meta-analysis, multivariable MR, mediation conducted ensure credibility depth this research. Results presence AN in relation greater likelihood (OR 1.08, 95% CI 1.02–1.14; p = 0.013). A meta-analysis validation cohorts supported observation 1.06, 1.02–1.09). None investigated appeared be impacted when set as exposure factor. Even after adjusting for confounding factors, remained statistically significant 1.02–1.15; Mediation analysis indicated N-formylmethionine levels (with mediated proportion 7.47%), cystatin D (2.97%), ketogluconate Metabolism (17.41%) N10-formyl-tetrahydrofolate biosynthesis (20.06%) might serve mediators pathogenesis AN-sepsis. Conclusion At gene prediction level, revealed that had association an increased In addition, levels, metabolism may function potential pathophysiology Our contribute investigation novel therapeutic strategies illness

Language: Английский

Citations

1
Severe mental illness and mortality in sepsis and septic shock: a systematic review and meta-analysis DOI
Inès Lakbar,

Eloise Maakaron,

Marc Léone

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(12), P. 3857 - 3864

Published: May 20, 2024

Language: Английский

Citations

1
The impact of hospital saturation on non-COVID-19 hospital mortality during the pandemic in France: a national population-based cohort study DOI Creative Commons
Laurent Boyer, Vanessa Pauly, Yann Brousse

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 5, 2024

A previous study reported significant excess mortality among non-COVID-19 patients due to disrupted surgical care caused by resource prioritization for COVID-19 cases in France. The primary objective was investigate if a similar impact occurred medical conditions and determine the effect of hospital saturation on during first year pandemic

Language: Английский

Citations

1
Previously healthy adults among septic patients: Population-level epidemiology and outcomes DOI
Lavi Oud, John Garza

Journal of Critical Care, Journal Year: 2023, Volume and Issue: 79, P. 154427 - 154427

Published: Sept. 15, 2023

Language: Английский

Citations

2