Antimicrobial Resistance: Addressing a Global Threat to Humanity

PLoS Medicine, Journal Year: 2023, Volume and Issue: 20(7), P. e1004264 - e1004264

Published: July 3, 2023

Language: Английский

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The scope of the antimicrobial resistance challenge

The Lancet, Journal Year: 2024, Volume and Issue: 403(10442), P. 2426 - 2438

Published: May 23, 2024

Language: Английский

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Burden of bacterial antimicrobial resistance in low-income and middle-income countries avertible by existing interventions: an evidence review and modelling analysis

The Lancet, Journal Year: 2024, Volume and Issue: 403(10442), P. 2439 - 2454

Published: May 23, 2024

Language: Английский

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Expanding antibiotic, vaccine, and diagnostics development and access to tackle antimicrobial resistance

The Lancet, Journal Year: 2024, Volume and Issue: 403(10443), P. 2534 - 2550

Published: May 23, 2024

Language: Английский

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Global trends in antibiotic consumption during 2016–2023 and future projections through 2030

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(49)

Published: Nov. 18, 2024

Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant among them. Analyzing trends and patterns in can aid developing policies mitigate the burden of antimicrobial disparities access antibiotics. Using pharmaceutical sales data licensed from IQVIA, we estimate national-level 67 countries during 2016–2023 analyze effects economic growth COVID-19 pandemic. Finally, project through 2030 assuming current trends. We find that estimated reported increased 16.3% 29.5 34.3 billion defined daily doses (DDDs) 2016 2023, reflecting 10.6% increase rate 13.7 15.2 DDDs per 1,000 inhabitants day. Increases were most pronounced upper-middle- lower-middle-income countries. While pandemic significantly reduced globally, was high-income countries, these reductions use 2020 sharper, lasted longer, than other By 2030, that, without rapidly nations, such as investments improve infrastructure, particularly water sanitation, along improved vaccination, will by 52.3% an 49.3 2023 75.1 DDDs.

Language: Английский

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Vaccine value profile for Klebsiella pneumoniae

Vaccine, Journal Year: 2024, Volume and Issue: 42(19), P. S125 - S141

Published: March 19, 2024

Klebsiella pneumoniae causes community- and healthcare-associated infections in children adults. Globally 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) 4.95 UI: 3.62-6.57) deaths were attributed to associated with bacterial antimicrobial resistance (AMR), respectively. K. was the second leading pathogen AMR resistant bacteria. Furthermore, rise of both hospital-acquired is a concern for neonates infants who are at high risk invasive disease. There limited antibiotic pipeline new antibiotics treat multidrug infections, vaccines targeted against considered be priority by World Health Organization. Vaccination pregnant women could reduce K.pneumoniae disease their young offspring. In addition, vulnerable children, adolescents adult populations underlying diseases such as immunosuppression from hematologic malignancy, chemotherapy, patients undergoing abdominal and/or urinary surgical procedures, or prolonged intensive care management also potential target groups vaccine. A 'Vaccine Value Profile' (VVP) K.pneumoniae, which contemplates vaccination protect babies birth through least three months age other high-risk populations, provides high-level, holistic assessment available information inform public health, economic societal value preventatives therapeutics. This VVP developed working group subject matter experts academia, non-profit organizations, public-private partnerships, multi-lateral collaboration stakeholders WHO. All contributors have extensive expertise on various elements collectively aimed identify current research knowledge gaps. The using only existing publicly information.

Language: Английский

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Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(10), P. 826 - 844

Published: Sept. 11, 2023

Language: Английский

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Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: A global public health threat

Microbiological Research, Journal Year: 2024, Volume and Issue: 288, P. 127839 - 127839

Published: Aug. 11, 2024

Language: Английский

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Glycoconjugate vaccines against antimicrobial resistant pathogens

Expert Review of Vaccines, Journal Year: 2023, Volume and Issue: 22(1), P. 1055 - 1078

Published: Oct. 30, 2023

Introduction Antimicrobial resistance (AMR) is responsible for the death of millions worldwide and stands as a major threat to our healthcare systems, which are heavily reliant on antibiotics fight bacterial infections. The development vaccines against main pathogens involved urgently required prevention remains essential rise AMR.

Language: Английский

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The role of vaccines in reducing antimicrobial resistance: A review of potential impact of vaccines on AMR and insights across 16 vaccines and pathogens

Vaccine, Journal Year: 2024, Volume and Issue: 42(19), P. S1 - S8

Published: June 13, 2024

In 2019, an estimated 4.95 million deaths were linked to antimicrobial resistance (AMR). Vaccines can prevent many of these by averting both drug-sensitive and resistant infections, reducing antibiotic usage, lowering the likelihood developing genes. However, their role in mitigating AMR is currently underutilized. This article builds upon previous research that utilizes Vaccine Value Profiles—tools assess health, socioeconomic, societal impact pathogens—to inform vaccine development. We analyze effects 16 pathogens, covered Profiles, on AMR, explore how vaccines could reduce AMR. The also provides insights into development usage. are crucial lessening infectious diseases curbing To fully realize potential, must be more prominently featured overall strategy combat requires ongoing investment new implementation additional prevention control measures address this global threat effectively.

Language: Английский

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