Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities

Molecules, Journal Year: 2016, Volume and Issue: 21(5), P. 529 - 529

Published: April 28, 2016

Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol) is a naturally occurring sesquiterpene alcohol that present in various plants with floral odor. It synthesized as an intermediate the production of (3E)-4,8-dimethy-1,3,7-nonatriene (DMNT), herbivore-induced volatile protects from herbivore damage. Chemically, nerolidol exists two geometric isomers, trans and cis form. The usage widespread across different industries. has been widely used cosmetics (e.g., shampoos perfumes) non-cosmetic products detergents cleansers). In fact, U.S. Food Drug Administration (FDA) also permitted use food flavoring agent. fact common ingredient many attracted researchers to explore more medicinal properties may exert beneficial effect on human health. Therefore, aim this review compile consolidate data pharmacological biological activities displayed by nerolidol. Furthermore, includes pharmacokinetic toxicological studies summary, demonstrated highlight prospects promising chemical or drug candidate field agriculture medicine.

Language: Английский

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Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads

Advances in pharmacology, Journal Year: 2017, Volume and Issue: unknown, P. 67 - 134

Published: Jan. 1, 2017

Language: Английский

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Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants

Molecules, Journal Year: 2015, Volume and Issue: 20(10), P. 18923 - 18966

Published: Oct. 16, 2015

In addition to interacting with functional proteins such as receptors, ion channels, and enzymes, a variety of drugs mechanistically act on membrane lipids change the physicochemical properties biomembranes reported for anesthetic, adrenergic, cholinergic, non-steroidal anti-inflammatory, analgesic, antitumor, antiplatelet, antimicrobial, antioxidant drugs. As well these membrane-acting drugs, bioactive plant components, phytochemicals, amphiphilic or hydrophobic structures, are presumed interact biological membranes biomimetic prepared phospholipids cholesterol, resulting in modification fluidity, microviscosity, order, elasticity, permeability potencies being consistent their pharmacological effects. A novel mechanistic point view phytochemicals would lead better understanding bioactivities, an insight into medicinal benefits, strategic implication discovering drug leads from plants. This article reviews interactions different classes by highlighting induced changes property. The be reviewed include membrane-interactive flavonoids, terpenoids, stilbenoids, capsaicinoids, phloroglucinols, naphthodianthrones, organosulfur compounds, alkaloids, anthraquinonoids, ginsenosides, pentacyclic triterpene acids, curcuminoids. interaction's applicability discovery phytochemical is also discussed while referring previous screening isolating studies.

Language: Английский

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Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review

Foods, Journal Year: 2021, Volume and Issue: 10(6), P. 1360 - 1360

Published: June 11, 2021

Propolis is a complex phytocompound made from resinous and balsamic material harvested by bees flowers, branches, pollen, tree exudates. Humans have used propolis therapeutically for centuries. The aim of this article to provide comprehensive review the antiviral, antibacterial, antifungal, antiparasitic properties propolis. mechanisms action are discussed. There two distinct impacts with regards antimicrobial anti-parasitic propolis, on pathogens host. With pathogens, acts disrupting ability invade host cells forming physical barrier inhibiting enzymes proteins needed invasion into cells. also inhibits replication process pathogens. Moreover, metabolic processes cellular organelles components responsible energy production. regard host, functions as an immunomodulator. It upregulates innate immunity modulates inflammatory signaling pathways. helps maintain host’s antioxidant status. More importantly, small number human clinical trials demonstrated efficacy safety adjuvant therapy pathogenic infections.

Language: Английский

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D-Limonene: Promising and Sustainable Natural Bioactive Compound

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4605 - 4605

Published: May 27, 2024

The discovery of antibiotics and pesticides has greatly contributed to the social economic development human society but, due long-term irrational application, it led drug-resistant microorganisms, environmental damage, other hazards, so selection alternative natural, safe, non-hazardous bioactive substances is an effective solution for this problem. D-limonene a compound widely present in various plant essential oils, exhibiting excellent broad-spectrum bioactivity promising prospects clinical application. This review provides detailed overview biological activities D-limonene, emphasizing its antimicrobial, anthelmintic, insecticidal, medicinal potential. While nanoencapsulation technology shows promise improving physicochemical properties enhancing practical applications, also crucial comprehensively evaluate potential side effects before use.

Language: Английский

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Rethinking how volatiles are released from plant cells

Trends in Plant Science, Journal Year: 2015, Volume and Issue: 20(9), P. 545 - 550

Published: July 17, 2015

Language: Английский

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The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis

PLoS ONE, Journal Year: 2015, Volume and Issue: 10(12), P. e0144946 - e0144946

Published: Dec. 16, 2015

Among neglected tropical diseases, leishmaniasis is one of the most important ones, affecting more than 12 million people worldwide. The available treatments are not well tolerated, and present diverse side effects, justifying search for new therapeutic compounds. In study, activity ursolic acid (UA) oleanolic (OA) were assayed in experimental cutaneous (in vitro vivo). Promastigote forms L. amazonensis incubated with OA UA 24h, effective concentration 50% (EC50) was estimated. Ultraestructural alterations Leishmania promastigotes after treatment evaluated by transmission electron microscopy, possible mode action through Annexin V propidium iodide staining, caspase 3/7 activity, DNA fragmentation transmembrane mitochondrial potential. potential intracellular amastigotes, its infected BALB/c mice. eliminated an EC50 6.4 μg/mL, comparable miltefosine, while presented only a marginal effect on promastigote at 100 μg/mL. mechanism which programmed cell death, independent 3/7, but it highly dependent mitochondria activity. toxic peritoneal macrophages from mice, able to eliminate associated nitric oxide (NO) production. did amastigotes nor trigger NO. mice submitted lesser lesion size parasitism compared control. This study showed, first time, that programed importantly, vivo. Therefore, can be considered interesting candidate future tests as prototype drug leishmaniasis.

Language: Английский

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Antiparasitic activity of nerolidol in a mouse model of schistosomiasis

International Journal of Antimicrobial Agents, Journal Year: 2017, Volume and Issue: 50(3), P. 467 - 472

Published: June 27, 2017

Language: Английский

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Melaleuca alternifolia (tea tree) oil and its monoterpene constituents in treating protozoan and helminthic infections

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 130, P. 110624 - 110624

Published: Sept. 2, 2020

Australian tea tree (Melaleuca alternifolia) oil (TTO) and its monoterpene constituents such as terpinen-4-ol (T4O), 1,8-cineole, limonene, p-cymene, α-terpinene have been shown to be effective in controlling a wide range of parasitic infections. The anti-parasitic effects these compounds are mainly due their anti-histamine anti-acetylcholinesterase activities well ability modulate host inflammatory responses. This review attempts summarize recent advances the uses TTO 15 major treating infections both humans animals. Activities against protozoans (Plasmodium falciparum, Leishmania spp., Trypanosoma Acanthamoeba castellanii, Trichomonas vaginalis, Eimeria, Ichthyophthirius multifiliis), nematodes (Haemonchus contortus Anisakis simplex), cestode (Echinococcus ortleppi), monogeneans (Gasterosteus spp. Dactylogyrus minutus) reported, showing good potentials Further studies necessary for developing anti-parasite therapies using or monoterpenes constituents.

Language: Английский

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Ecotoxicity of a novel biopesticide from Artemisia absinthium on non-target aquatic organisms

Chemosphere, Journal Year: 2018, Volume and Issue: 216, P. 131 - 146

Published: Oct. 18, 2018

Biopesticides are increasingly being used to replace synthetic pesticides for pest control. This change raises concern its environmental impacts, especially on non-target organisms. In this study, the ecotoxicological effects of a potential nematicide from Spanish populations Artemisia absinthium (var. Candial) were evaluated freshwater and aquatic The study focused aqueous extract (hydrolate), principal component which ((−) -(Z) −2,6-dimethylocta-5,7-diene-2,3-diol) is responsible nematicidal effect. Until now, hydrolate has been considered byproduct process obtain essential oils, there no studies ecotoxicity any plant with biopesticide properties. Our results indicated that A. caused acute toxicity organisms at dilutions as low 0.2%. sensitivity organisms, most least sensitive, was: Daphnia magna (LC50 = 0,236%) > Vibrio fisheri 1,85%) Chlamydomonas reinhardtii 16,49). Moreover, organic was highly toxic D. 0,093 mg/L). also tested natural river microbial community. Bacterial growth not affected; physiology community only slightly modified, namely through an increased ability degrade different substrates, mainly carbohydrates. provides first time exhaustive assessment exposure plant-derived shows these products may cause broad range

Language: Английский

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