The gut–kidney axis

Pediatric Nephrology, Journal Year: 2016, Volume and Issue: 32(11), P. 2005 - 2014

Published: Nov. 15, 2016

Language: Английский

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Gut microbiome in chronic kidney disease: challenges and opportunities

Translational research, Journal Year: 2016, Volume and Issue: 179, P. 24 - 37

Published: May 1, 2016

Language: Английский

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Chronic kidney disease and the gut microbiome

AJP Renal Physiology, Journal Year: 2019, Volume and Issue: 316(6), P. F1211 - F1217

Published: March 13, 2019

The gut microbiome is composed of a diverse population bacteria that have beneficial and adverse effects on human health. has recently gained attention increasingly noted to play significant role in health number disease states. Increasing urea concentration during chronic kidney (CKD) leads alterations the intestinal flora can increase production gut-derived toxins alter epithelial barrier. These changes lead an acceleration process injury. A strategies been proposed interrupt this pathway injury CKD. purpose review summarize CKD, tools used study microbial population, attempts its composition for therapeutic purposes.

Language: Английский

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Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS–based metabolomics approach

Kidney International, Journal Year: 2017, Volume and Issue: 92(3), P. 634 - 645

Published: April 8, 2017

Gut microbiota is involved in the metabolism of uremic solutes. However, precise influence to retention solutes CKD obscure. To clarify this, we compared adenine-induced renal failure and control mice under germ-free or specific pathogen-free (SPF) conditions, examining metabolite profiles plasma, feces, urine using a capillary electrophoresis time-of-flight mass spectrometry-based approach. Mice with conditions demonstrated significant changes plasma metabolites. Among 183 detected solutes, levels 11 including major toxins, were significantly lower than SPF failure. These considered microbiota-derived included indoxyl sulfate, p-cresyl phenyl cholate, hippurate, dimethylglycine, γ-guanidinobutyrate, glutarate, 2-hydroxypentanoate, trimethylamine N-oxide, phenaceturate. Metabolome profiling showed that these classified into three groups depending on their origins: completely derived from (indoxyl sulfate), both host (dimethylglycine), dietary components (trimethylamine N-oxide). Additionally, resulted disappearance colonic short-chain fatty acids, decreased utilization intestinal amino more severe damage Microbiota-derived acids efficient acid may have renoprotective effect, loss factors exacerbate Thus, contributes substantially production harmful but conversely, growth without has effects progression.

Language: Английский

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Kidney disease and obesity: epidemiology, mechanisms and treatment

Nature Reviews Nephrology, Journal Year: 2017, Volume and Issue: 13(3), P. 181 - 190

Published: Jan. 16, 2017

Language: Английский

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Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins

Clinical Science, Journal Year: 2018, Volume and Issue: 132(5), P. 509 - 522

Published: March 9, 2018

In chronic kidney disease (CKD), influx of urea and other retained toxins exerts a change in the gut microbiome. There is decreased number beneficial bacteria that produce short-chain fatty acids, an essential nutrient for colonic epithelium, concurrent with increase uremic such as indoxyl sulphate, p-cresyl trimethylamine-N-oxide (TMAO). Due to intestinal wall inflammation degradation intercellular tight junctions, gut-derived translocate into bloodstream exert systemic effects. this review, we discuss evidence supporting role promoting multiorgan dysfunction via inflammatory, oxidative stress, apoptosis pathways. End-organ effects include vascular calcification, fibrosis, anemia, impaired immune system, adipocyte insulin resistance, low turnover bone disease. Higher blood levels are associated increased cardiovascular events mortality CKD population. Clinical trials have examined interventions trap toxic products or reverse microbial dysbiosis oral activated charcoal AST-120, prebiotics probiotics not shown impact on survival outcomes but were limited by sample size short trials. summary, microbiome major contributor adverse progression CKD.

Language: Английский

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Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 76(24), P. 4961 - 4978

Published: May 30, 2019

Language: Английский

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Intestinal microbiome and fitness in kidney disease

Nature Reviews Nephrology, Journal Year: 2019, Volume and Issue: 15(9), P. 531 - 545

Published: June 26, 2019

Language: Английский

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The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

Frontiers in Microbiology, Journal Year: 2020, Volume and Issue: 11

Published: June 25, 2020

The gastrointestinal (GI) microbiome of cats and dogs is increasingly recognized as a metabolically active organ inextricably linked to pet health. Food serves substrate for the GI plays significant role in defining composition metabolism microbiome. microbiome, turn, facilitates host's nutrient digestion production postbiotics, which are bacterially derived compounds that can influence Consequently, owners have shaping through food they choose provide. Yet, clear understanding impact these choices on thus overall health pet, lacking. Pet foods formulated contain typical nutritional building blocks carbohydrates, proteins, fats, but include microbiome-targeted ingredients, such prebiotics probiotics. Each categories, well their relative proportions food, affect and/or function Accumulating evidence suggests dietary components may not only disease, also allergies, oral health, weight management, diabetes, kidney disease changes Until recently, focus research was characterize alterations states, while less effort has been devoted how nutrition by modifying function. This review summarizes examines impacting host variety states. Understanding modulate reveal new avenues enhancing resilience dogs.

Language: Английский

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The Signaling of Cellular Senescence in Diabetic Nephropathy

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 16

Published: Oct. 3, 2019

Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western countries. Notably, it has a rapidly rising prevalence China. The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal (ESRD) death. However, pathogenic mechanisms diabetic have not been determined. Cellular senescence, which recently gained broad attention, thought be an important player onset development nephropathy. In this issue, we generally review cellular senescence nephropathy, involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss Klotho, Wnt/β-catenin signaling activation, persistent inflammation, accumulation uremic toxins. Moreover, highlight potential therapeutic targets provide clues for clinical strategies.

Language: Английский

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