Acute kidney injury

Nature Reviews Disease Primers, Journal Year: 2021, Volume and Issue: 7(1)

Published: July 15, 2021

Language: Английский

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Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

Gut, Journal Year: 2020, Volume and Issue: 69(12), P. 2131 - 2142

Published: April 2, 2020

Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced studies in animals. The aim the study is to characterise relationships between intestinal microbiome composition, toxins and human end-stage disease (ESRD). Design Characterisation microbiome, serum faecal metabolome phenotypes a cohort 223 patients ESRD 69 healthy controls. Multidimensional data integration reveal links these datasets use chronic kidney (CKD) rodent models test effects on toxin accumulation severity. Results A group species enriched correlates tightly patient clinical variables encode functions involved secondary bile acids synthesis; relative abundance or concentrations metabolites. Microbiota transplanted injured germ-free mice antibiotic-treated rats induce higher production aggravated fibrosis oxidative stress more than microbiota Two species, Eggerthella lenta Fusobacterium nucleatum , increase promote development CKD rat model. probiotic Bifidobacterium animalis decreases reduces levels severity rats. Conclusion Aberrant sculpts detrimental aggravating outcomes, suggesting that will be promising target for diminishing toxicity those patients. Trial registration number This was registered at ClinicalTrials.gov ( NCT03010696 ).

Language: Английский

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Role of the gut microbiota in type 2 diabetes and related diseases

Metabolism, Journal Year: 2021, Volume and Issue: 117, P. 154712 - 154712

Published: Jan. 23, 2021

Language: Английский

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Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay

Trends in Endocrinology and Metabolism, Journal Year: 2020, Volume and Issue: 31(11), P. 818 - 834

Published: April 10, 2020

Language: Английский

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Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2020, Volume and Issue: 17(3), P. 153 - 171

Published: Sept. 22, 2020

Language: Английский

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Association of metabolic dysfunction-associated fatty liver disease with kidney disease

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(4), P. 259 - 268

Published: Jan. 10, 2022

Language: Английский

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The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9641 - 9641

Published: Sept. 6, 2021

Diabetic kidney disease (DKD) is a progressive disorder, which increasing globally in prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal clinical management, significant number patients with develop DKD. Hence, hitherto unrecognized factors are likely be involved initiation progression An extensive studies have demonstrated role microbiota health disease. Dysregulation resulting deficiency short chain fatty acids (SCFAs) such as propionate, acetate, butyrate, by-products healthy gut metabolism, been obesity, type 1 2 diabetes. However, it not clear date whether changes causative or merely associated diseases. It also protective effects on humans. Few investigated centrality reduced SCFA DKD development potential therapeutic supplemental SCFAs insulin resistance, inflammation, metabolic changes. receptors expressed kidneys, emerging data that intestinal dysbiosis activates renal renin-angiotensin system, contributes In this review, we will summarize complex relationship between kidney, examine evidence for obesity-related disease, explore mechanisms involved. addition, describe therapies modulate prevent reduce progression.

Language: Английский

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Targeting innate immunity-driven inflammation in CKD and cardiovascular disease

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(12), P. 762 - 778

Published: Sept. 5, 2022

Language: Английский

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Coupling Probiotics with 2D CoCuMo‐LDH Nanosheets as a Tumor‐Microenvironment‐Responsive Platform for Precise NIR‐II Photodynamic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 13, 2023

Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as TME-responsive platform NIR-II The CoCuMo-LDH loaded on LA can be transformed from crystalline into amorphous through etching by LA-metabolite-enabled low pH and overexpressed glutathione. TME-induced in situ amorphization of boost its photodynamic activity singlet oxygen (1 O2 ) generation under 1270 nm laser irradiation relative 1 quantum yield 1.06, which highest among previously NIR-excited PSs. In vitro vivo assays prove that LA&LDH effectively achieve complete cell apoptosis eradication irradiation. This study proves used highly efficient

Language: Английский

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Targeting Lactobacillus johnsonii to reverse chronic kidney disease

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 5, 2024

Abstract Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing CKD. Here, using microbiomics 480 participants including healthy controls and patients stage 1–5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae- Lactobacillus - johnsonii correlated CKD progression, whose abundance strongly clinical markers. L. reduced rats adenine-induced supplementation ameliorated lesion. Serum indole-3-aldehyde (IAld), level negatively creatinine rats, decreased serum of induced unilateral ureteral obstruction (UUO) 5/6 nephrectomy (NX) as well late patients. Treatment IAld dampened lesion through aryl hydrocarbon receptor (AHR) signal or UUO, cultured 1-hydroxypyrene-induced HK-2 cells. Renoprotective effect was partially diminished AHR deficiency mice Our further data showed treatment attenuated by via increasing level. Taken together, targeting might reverse This study provides a deeper understanding how microbial-produced tryptophan metabolism affects host discovers potential pathways for prophylactic therapeutic treatments

Language: Английский

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