Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(6), P. 1724 - 1724

Published: June 11, 2018

Arterial hypertension is a disease with complex pathogenesis. Despite considerable knowledge about this socially significant disease, the role of magnesium deficiency (MgD) as risk factor not fully understood. Magnesium natural calcium antagonist. It potentiates production local vasodilator mediators (prostacyclin and nitric oxide) alters vascular responses to variety vasoactive substances (endothelin-1, angiotensin II, catecholamines). MgD stimulates aldosterone inflammatory response, while expression/activity various antioxidant enzymes (glutathione peroxidase, superoxide dismutase, catalase) levels important antioxidants (vitamin C, vitamin E, selenium) are decreased. balances effects catecholamines in acute chronic stress. may be associated development insulin resistance, hyperglycemia, changes lipid metabolism, which enhance atherosclerotic arterial stiffness. regulates collagen elastin turnover wall matrix metalloproteinase activity. helps protect elastic fibers from deposition maintains elasticity vessels. Considering numerous positive on number mechanisms related hypertension, consuming healthy diet that provides recommended amount can an appropriate strategy for helping control blood pressure.

Language: Английский

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The Role of Magnesium in the Pathogenesis of Metabolic Disorders

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1714 - 1714

Published: April 20, 2022

Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It involved in many fundamental processes, and Mg deficiency often correlated with negative health outcomes. On the one hand, most western civilizations consume less than recommended daily allowance of Mg. other a growing body evidence has indicated that chronic hypomagnesemia may be implicated pathogenesis various metabolic disorders such as overweight obesity, insulin resistance (IR) type 2 diabetes mellitus (T2DM), hypertension (HTN), changes lipid metabolism, low-grade inflammation. High intake diet and/or supplementation seems to prevent complications. The protective action include limiting adipose tissue accumulation, improving glucose enhancing endothelium-dependent vasodilation, normalizing profile, attenuating inflammatory processes. Thus, it currently plays important role developing associated although more randomized controlled trials (RCTs) evaluating strategies are needed. This work represents review synthesis recent data on disorders.

Language: Английский

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Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies

Nutrition Journal, Journal Year: 2017, Volume and Issue: 16(1)

Published: May 5, 2017

The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum concentration risk hypertension. We aimed to review evidence from perform a dose-response meta-analysis investigate relationship concentrations searched systematically PubMed, EMBASE Cochrane Library databases October 1951 through June 2016. Prospective reporting effect estimates with 95% confidence intervals (CIs) for hypertension in more than two categories and/or were included. Random-effects models used combine estimated effects. Nine articles (six on intake, one both) ten studies, including 20,119 cases 180,566 participates, eligible inclusion meta-analysis. found an inverse [relative (RR) = 0.92; CI: 0.86, 0.98] comparing highest group lowest. A 100 mg/day increment was associated 5% reduction (RR 0.95; 0.90, 1.00). marginally significant 0.91; 0.80, 1.02). Current supports However, about is limited.

Language: Английский

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Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review

Nutrients, Journal Year: 2017, Volume and Issue: 9(6), P. 538 - 538

Published: May 25, 2017

Low-grade metabolic acidosis is a condition characterized by slight decrease in blood pH, within the range considered normal, and feeding one of main factors that may influence occurrence such condition. The excessive consumption acid precursor foods (sources phosphorus proteins), to detriment those precursors bases potassium, calcium, magnesium), leads acid-base balance volubility. If this occurs prolonged, chronic way, low-grade can become significant predispose imbalances as kidney stone formation, increased bone resorption, reduced mineral density, loss muscle mass, well risk diseases type 2 diabetes mellitus, hypertension, non-alcoholic hepatic steatosis. Considering increase number studies investigating diet-induced on clinical outcomes, review gathers available evidence evaluating association disturbance imbalances, related mechanisms. It necessary look at western dietary pattern most countries increasing incidence non-comunicable for between fruit vegetable intake appropriate supply protein, mainly from animal sources, so it does not exceed daily recommendations.

Language: Английский

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The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature

Food Research International, Journal Year: 2019, Volume and Issue: 128, P. 108749 - 108749

Published: Nov. 7, 2019

Language: Английский

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Sleep architecture and vitamin D in hypertensives with obstructive sleep apnea: A polysomnographic study

Dental and Medical Problems, Journal Year: 2023, Volume and Issue: 61(1), P. 43 - 52

Published: Oct. 20, 2023

Background.Obstructive sleep apnea (OSA) and arterial hypertension (AH) are closely linked disorders with common pathophysiological features.Objectives.The present study aimed to investigate the relationship between AH OSA by examining architecture, vitamin D concentration electrolyte levels in patients these coexisting conditions. Material methods.A total of 133 suspected having were recruited for examination.The participants divided into 2 groups: hypertensives (n = 52); normotensives 81).One full-night polysomnographic examinations conducted, followed statistical analysis collected data. Results.Hypertensive individuals displayed increased apnea-hypopnea index (AHI), oxygen desaturation (ODI), respiratory arousal (RAI), periodic limb movement (PLMI) as compared non-hypertensive individuals.Moreover, efficiency (SE), bruxism (BAI) saturation (SpO ) level decreased hypertensive group.In terms biochemical parameters, exhibited a lower magnesium (Mg) level, higher C-reactive protein (CRP), uric acid (UA) glucose.Notably, there no differences normotensive individuals. Conclusions.The explored potential influence calcium (Ca), Mg, D, UA concentrations on architecture comorbid OSA.The findings revealed several notable associations.Firstly, fragmentation correlated Ca suggesting role both arousals.Secondly, was AHI fragmentation.Additionally, alterations Mg observed among OSA.However, further research is needed fully comprehend impact factors apnea.

Language: Английский

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Rare earth elements and hypertension risk among housewives: A pilot study in Shanxi Province, China

Environmental Pollution, Journal Year: 2016, Volume and Issue: 220, P. 837 - 842

Published: Nov. 2, 2016

Language: Английский

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Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies

Journal of Trace Elements in Medicine and Biology, Journal Year: 2016, Volume and Issue: 38, P. 64 - 73

Published: March 31, 2016

Language: Английский

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Watermelon extract reduces blood pressure but does not change sympathovagal balance in prehypertensive and hypertensive subjects

Blood Pressure, Journal Year: 2016, Volume and Issue: 25(4), P. 244 - 248

Published: March 7, 2016

Previous studies have shown that watermelon extract reduces blood pressure through vasodilation. However, those not verified whether sympathetic nervous activity is influenced by extract. This study aimed to evaluate the effect of supplementation with for 6 weeks on and sympathovagal balance prehypertensive hypertensive individuals. Forty volunteers participated in a randomized, double-blind, experimental placebo-controlled study. They consumed g daily (n = 20; age 48.7 ± 1.9 years, 10 men) or placebo 47.4 1.2 11 weeks. Blood cardiac autonomic modulation were measured. Watermelon promoted significant reduction systolic (137.8 3.9 126.0 4.0 mmHg, p < 0.0001) diastolic (79.2 2.2 72.3 2.0 0.001) pressure, but showed no differences compared group. occurred without change from beginning (1.7 0.1) end 0.4). In conclusion, individuals, does alter these

Language: Английский

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Association of hypomagnesemia with cardiovascular diseases and hypertension

International Journal of Cardiology Hypertension, Journal Year: 2019, Volume and Issue: 1, P. 100005 - 100005

Published: May 1, 2019

The objective of this study was to review the current evidence on effects Mg2+ deficiency cardiovascular disease (CVD) and hypertension, since is a potent vasodilator modulates vasomotor tone, blood pressure peripheral flow. Several factors could contribute its when it occurs, associated with an increased incidence (CVD), heart failure (HF), cardiac arrhythmias. In order get better updated perspective status implications in CVD, arrhythmias, focused Medline search English language literature conducted between 2014 2018 30 pertinent papers were retrieved. analysis data showed that difficult occur, under normal circumstances, because plentiful green leafy vegetables, cereals, nuts, drinking water. However, can occur special circumstances such as hypertension HF treated large doses diuretics, patients chronic kidney (CKD) hemodialysis, gastroesophageal reflux proton pump inhibitors. When hypomagnesemia serious arrhythmias aggravation hypertension. suggests does HF, Retaining levels will prevent onset these diseases.

Language: Английский

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