Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Advances in Nutrition, Journal Year: 2017, Volume and Issue: 8(6), P. 793 - 803

Published: Nov. 1, 2017

Language: Английский

---

Magnesium deficiency and increased inflammation: current perspectives

Journal of Inflammation Research, Journal Year: 2018, Volume and Issue: Volume 11, P. 25 - 34

Published: Jan. 1, 2018

Abstract: Animal studies have shown that magnesium deficiency induces an inflammatory response results in leukocyte and macrophage activation, release of cytokines acute-phase proteins, excessive production free radicals. vitro indicate the primary mechanism through which has this effect is increasing cellular Ca 2+ , signal priming cells to give response. Primary pro-inflammatory such as tumor necrosis factor-α interleukin (IL)-1; messenger cytokine IL-6; responders E-selectin, intracellular adhesion molecule-1 vascular cell molecule-1; reactants C-reactive protein fibrinogen been determined associate with chronic low-grade inflammation (inflammatory stress). When dietary intake, supplementation, and/or serum concentration suggest/s presence deficiency, it often associated pathological conditions for stress considered a risk factor. adequate status, generally not found significantly affect markers or disease. The consistency these findings can be modified by other nutritional metabolic factors oxidative stress. In spite this, date provide convincing evidence significant contributor factor variety cardiovascular disease, hypertension, diabetes. Because commonly occurs countries where foods rich are consumed recommended amounts, should element concern health well-being countries. Keywords: adequacy, stress, disease

Language: Английский

---

Magnesium: Are We Consuming Enough?

Nutrients, Journal Year: 2018, Volume and Issue: 10(12), P. 1863 - 1863

Published: Dec. 2, 2018

Magnesium is essential for maintaining normal cellular and organ function. In-adequate magnesium balance associated with various disorders, such as skeletal deformities, cardiovascular diseases, metabolic syndrome. Unfortunately, routinely measured serum levels do not always reflect total body status. Thus, blood eclipse the wide-spread deficiency. Other measuring methods, including loading test, may provide more accurate reflections of status thus improve identification magnesium-deficient individuals, prevent deficiency related complications.

Language: Английский

---

Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(6), P. 1724 - 1724

Published: June 11, 2018

Arterial hypertension is a disease with complex pathogenesis. Despite considerable knowledge about this socially significant disease, the role of magnesium deficiency (MgD) as risk factor not fully understood. Magnesium natural calcium antagonist. It potentiates production local vasodilator mediators (prostacyclin and nitric oxide) alters vascular responses to variety vasoactive substances (endothelin-1, angiotensin II, catecholamines). MgD stimulates aldosterone inflammatory response, while expression/activity various antioxidant enzymes (glutathione peroxidase, superoxide dismutase, catalase) levels important antioxidants (vitamin C, vitamin E, selenium) are decreased. balances effects catecholamines in acute chronic stress. may be associated development insulin resistance, hyperglycemia, changes lipid metabolism, which enhance atherosclerotic arterial stiffness. regulates collagen elastin turnover wall matrix metalloproteinase activity. helps protect elastic fibers from deposition maintains elasticity vessels. Considering numerous positive on number mechanisms related hypertension, consuming healthy diet that provides recommended amount can an appropriate strategy for helping control blood pressure.

Language: Английский

---

The Role of Magnesium in the Pathogenesis of Metabolic Disorders

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1714 - 1714

Published: April 20, 2022

Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It involved in many fundamental processes, and Mg deficiency often correlated with negative health outcomes. On the one hand, most western civilizations consume less than recommended daily allowance of Mg. other a growing body evidence has indicated that chronic hypomagnesemia may be implicated pathogenesis various metabolic disorders such as overweight obesity, insulin resistance (IR) type 2 diabetes mellitus (T2DM), hypertension (HTN), changes lipid metabolism, low-grade inflammation. High intake diet and/or supplementation seems to prevent complications. The protective action include limiting adipose tissue accumulation, improving glucose enhancing endothelium-dependent vasodilation, normalizing profile, attenuating inflammatory processes. Thus, it currently plays important role developing associated although more randomized controlled trials (RCTs) evaluating strategies are needed. This work represents review synthesis recent data on disorders.

Language: Английский

---

Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(12), P. e2324 - e2333

Published: Feb. 14, 2024

Abstract Context The association between magnesium status and metabolic syndrome (MetS) remains unclear. Objective This study aimed to examine the relationship kidney reabsorption-related depletion score (MDS) MetS among US adults. Methods We analyzed data from 15 565 adults participating in National Health Nutrition Examination Survey (NHANES) 2003 2018. was defined according Cholesterol Education Program's Adult Treatment Panel III report. MDS is a scoring system developed predict of deficiency that fully considers pathophysiological factors influencing kidneys' reabsorption capability. Weighted univariate multivariable logistic regression were used assess MetS. Restricted cubic spline (RCS) analysis conducted characterize dose-response relationships. Stratified analyses by sociodemographic lifestyle also performed. Results In both analyses, higher significantly associated with increased odds Each unit increase approximately 30% risk for MetS, even after adjusting confounding (odds ratio 1.31; 95% CI, 1.17-1.45). RCS graphs depicted linear across range. positive correlation remained consistent various population subgroups exhibited no significant interaction age, sex, race, adiposity, smoking status, or alcohol consumption. Conclusion Higher urinary loss as quantified may be an independent factor adults, irrespective behavioral factors. Optimizing nutritional could potentially confer benefits patients

Language: Английский

---

Comparative effects of different dietary approaches on blood pressure in hypertensive and pre-hypertensive patients: A systematic review and network meta-analysis

Critical Reviews in Food Science and Nutrition, Journal Year: 2018, Volume and Issue: 59(16), P. 2674 - 2687

Published: May 2, 2018

Pairwise meta-analyses have shown beneficial effects of individual dietary approaches on blood pressure but their comparative not been established.Therefore we performed a systematic review different intervention trials and estimated the aggregate through network meta-analysis including hypertensive pre-hypertensive patients.PubMed, Cochrane CENTRAL, Google Scholar were searched until June 2017. The inclusion criteria defined as follows: i) Randomized trial with approach; ii) adult patients; iii) minimum period 12 weeks. In order to determine pooled effect each relative other for both diastolic systolic (SBP DBP), random was performed.A total 67 comparing 13 (DASH, low-fat, moderate-carbohydrate, high-protein, low-carbohydrate, Mediterranean, Palaeolithic, vegetarian, low-GI/GL, low-sodium, Nordic, Tibetan, control) enrolling 17,230 participants included. meta-analysis, DASH, low-glycaemic index, low-fat significantly more effective in reducing SBP (-8.73 -2.32 mmHg) DBP (-4.85 -1.27 compared control diet. According SUCRAs, DASH diet ranked most approach (90%) (91%), followed by low-carbohydrate (ranked 3rd SBP) or Mediterranean DBP). For comparisons, credibility evidence rated very low moderate, exception vs. which quality high.The present suggests that might be measure reduce among patients based high evidence.

Language: Английский

---

Circulating magnesium levels and incidence of coronary heart diseases, hypertension, and type 2 diabetes mellitus: a meta-analysis of prospective cohort studies

Nutrition Journal, Journal Year: 2017, Volume and Issue: 16(1)

Published: Sept. 19, 2017

Data on the associations between circulating magnesium (Mg) levels and incidence of coronary heart diseases (CHD), hypertension, type 2 diabetes mellitus (T2DM) are inconsistent inconclusive. The aim this study was to examine Mg in relation CHD, T2DM. Prospective cohort studies published before May 2017 were searched through PubMed, EmBase, SCOPUS, Google Scholar. A total 11 that reported multivariable-adjusted interest identified. Information characteristics participants, exposure, main outcomes, risk estimates, cofounders extracted analyzed. Of included studies, 5 results CHD (38,808 individuals [4437 cases] with an average 10.5-year follow-up), 3 hypertension (14,876 participants [3149 a 6.7-year 4 T2DM (31,284 [2680 8.8-year follow-up). Comparing highest lowest category concentration, pooled relative risks [RRs] (95% confidence intervals [CIs]) 0.86 (0.74, 0.996), 0.91 (0.80, 1.02), 0.64 (0.50, 0.81) for T2DM, respectively. Every 0.1 mmol/L increment associated 4% (RR, 0.96; 95% CI: 0.94, 0.99) reduction incidence. No significant linear association found 0.89; 0.77, 1.03) 0.90; 0.81, 1.002). observed sensitive exclusion individual studies. Findings meta-analysis suggest inversely Additional needed provide more solid evidence identify optimal range concentration respect primary prevention

Language: Английский

---

Magnesium and Hypertension in Old Age

Nutrients, Journal Year: 2020, Volume and Issue: 13(1), P. 139 - 139

Published: Dec. 31, 2020

Hypertension is a complex condition in which various actors and mechanisms combine, resulting cardiovascular cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, health expenses worldwide. In last decades, there has been an exceptional amount experimental, epidemiological, clinical studies confirming close relationship between magnesium deficit high blood pressure. Multiple may help to explain bulk evidence supporting protective effect against hypertension its complications. increases sharply with advancing age, hence older persons are those affected by negative consequences. They also more frequently at risk deficiency multiple mechanisms, may, least part, higher frequency long-term The for favorable on emphasizes importance broadly encouraging intake foods such as vegetables, nuts, whole cereals legumes, optimal dietary sources magnesium, avoiding processed food, very poor other fundamental nutrients, order prevent hypertension. some cases, when diet not enough maintain adequate status, supplementation be benefit shown well tolerated.

Language: Английский

---

A Systematic Review on Processed/Ultra-Processed Foods and Arterial Hypertension in Adults and Older People

Nutrients, Journal Year: 2022, Volume and Issue: 14(6), P. 1215 - 1215

Published: March 13, 2022

The increase in the availability of processed and ultra-processed foods has altered eating patterns populations, these constitute an exposure factor for development arterial hypertension. This systematic review analyzed evidence association between consumption processed/ultra-processed hypertension adults older people. Electronic searches relevant articles were performed PUBMED, EMBASE LILACS databases. was conducted following PRISMA guidelines Newcastle-Ottawa Scale. search databases led to retrieval 2323 articles, eight which included review. A positive found blood pressure/arterial hypertension, whereas insufficient results reveal high developed middle-income countries, warning health risks such foods, have a energy density are rich salt, sugar fat. findings underscore urgent need adoption measures that exert impact on quality life especially those at greater risk, as

Language: Английский

---