A Machine-Learning-Based System for Prediction of Cardiovascular and Chronic Respiratory Diseases

Journal of Healthcare Engineering, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 17

Published: Nov. 1, 2021

Cardiovascular and chronic respiratory diseases are global threats to public health cause approximately 19 million deaths worldwide annually. This high mortality rate can be reduced with the use of technological advancements in medical science that facilitate continuous monitoring physiological parameters-blood pressure, cholesterol levels, blood glucose, etc. The futuristic values these critical or vital sign parameters not only enable in-time assistance from experts caregivers but also help patients manage their status by receiving relevant regular alerts/advice healthcare practitioners. In this study, we propose a machine-learning-based prediction classification system determine related signs for both cardiovascular diseases. Based on values, proposed classify patients' alarm experts. model, have used real dataset. To predict next 1-3 minutes several regression techniques (i.e., linear polynomial degrees 2, 3, 4) been tested. For caregivers, 60-second emergency assistance, 3-minute is used. predicted patient's overall assessed using three machine learning classifiers, i.e., Support Vector Machine (SVM), Naive Bayes, Decision Tree. Our results show Tree correctly based abnormal helpful timely care patients.

Language: Английский

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The Effect of Different Breathing Conditions on Cerebral Blood Flow in Young Males During Maximal Aerobic Exercise: A Pilot Study

Advanced Exercise and Health Science, Journal Year: 2024, Volume and Issue: 1(3), P. 195 - 203

Published: July 27, 2024

During aerobic exercise, cerebral blood flow (CBF) decreases past 70% of maximal oxygen uptake (VO2), but transient hypercapnia could mitigate the reduction. To examine effect oral (OB), nasal (NB), and combined (CB) breathing on CBF during a graded exercise test (GXT). Six young males (age: 21.8 ± 2.3 years) performed three GXTs until volitional fatigue using randomized condition (OB, NB, or CB) order. Respiratory gases were assessed via metabolic cart. Ultrasound sonography (7.5 MHz linear transducer) was utilized to assess peak systolic velocity (PSV), end-diastolic (EDV), vessel diameter internal (ICA) external (ECA) carotid artery. A one-way ANCOVA, with VO2 as covariate, followed by Bonferroni post-hoc analysis, differences between conditions. The end-tidal partial pressure CO2 (PetCO2) significantly greater (p = 0.006) NB (33.16 1.37 mmHg) than that CB (26.63 1.32 OB (26.72 1.37) at 100% VO2max. There trend PSV in ICA throughout entire GXT only 0.027) (126.12 7.51 cm/s) compared (92.47 7.34 not (111.91 7.14 GXT, demonstrated superior capacity increase CBF, denoted higher OB, which might be partly related an increased PetCO2.

Language: Английский

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High-flow nasal cannula therapy, factors affecting effective inspired oxygen fraction: an experimental adult bench model

Journal of Clinical Monitoring and Computing, Journal Year: 2021, Volume and Issue: 36(5), P. 1441 - 1448

Published: Dec. 8, 2021

Language: Английский

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Long-Term Effects of Prematurity on Resting Ventilatory Response to Hypercapnia

High Altitude Medicine & Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 420 - 425

Published: Dec. 1, 2021

Manferdelli, Giorgio, Benjamin J. Narang, Mathias Poussel, Damjan Osredkar, Grégoire P. Millet, and Tadej Debevec. Long-term effects of prematurity on resting ventilatory response to hypercapnia. High Alt Med Biol. 22:420-425, 2021. Background: This study investigated the hypercapnia in prematurely born adults. Materials Methods: Seventeen preterm fourteen full-term adults were exposed normoxic (two 5-minute periods at 3% 6% carbon dioxide [CO2] interspersed by normoxia). Pulmonary ventilation ([Formula: see text]) end-tidal partial pressure CO2 (Petco2) measured continuously. Results: No difference lung function was observed between Petco2 lower than (p < 0.05) during normoxia. During exposure CO2, both [Formula: text] increased a similar way However, end period, there significantly higher compared with (30.2 ± 7.5 vs. 23.7 4.5 L/min, p 0.0001), whereas no for (46.9 2.1 50.6 = 0.99). Breath frequency (17.9 4.0 12.8 3.5 b/min, 0.01) exposure. Conclusions: Although data suggest that results hypocapnia, exact underlying mechanisms remain be elucidated. Moreover, seem have chemosensitivity

Language: Английский

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Percutaneous Closure of PFO in Patients with Reduced Oxygen Saturation at Rest and during Exercise: Short- and Long-Term Results

Journal of Interventional Cardiology, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 8

Published: March 20, 2020

Background . A patent foramen ovale (PFO) is a rare cause of hypoxemia and clinical symptoms dyspnea. Due to right-to-left shunt, desaturated blood enters the systemic circulation in subset patients resulting dyspnea subsequent reduction quality life (QoL). Percutaneous closure PFO treatment choice. Objectives This retrospective multicentre study evaluates short- long-term results percutaneous with and/or reduced oxygen saturation. Methods Patients respiratory were selected from databases containing all percutaneously closed between January 2000 September 2018. Improvement dyspnea, oxygenation, QoL was investigated using pre- postprocedural lung function parameters two questionnaires (SF-36 PFSDQ-M). Results The average follow-up period 36 [12–43] months, ranging 0 months 14 years. successful 15 16 patients. All reported subjective improvement immediately after device deployment, consistent their saturation (from 90 ± 6% 94 [92–97%] on room air upright position) (p<0.05). Both also indicated an closure. early late deaths unrelated procedure. Conclusion PFO-related can be treated successfully intervention long-lasting benefits saturation, QoL.

Language: Английский

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Primum non nocere; It’s time to consider altitude training as the medical intervention it actually is!

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 13, 2022

Sleep is one of the most important aspects recovery, and known to be severely affected by hypoxia. The present position paper focuses on sleep as a strong moderator altitude training-response. Indeed, response training highly variable, it not fixed classifiable trait, rather state that determined multiple factors (e.g., iron status, dose, pre-intervention hemoglobin mass, load, recovery). We an overview evidence showing sleep, more specifically prolonged negative impact nocturnal breathing pattern, affecting mainly deep thus core physiological recovery during could play role in intra- interindividual variability training-associated responses professional recreational athletes. conclude our with set suggested recommendations customize application specific needs vulnerabilities each athlete (i.e., primum non nocere). Several have been identified sex, polymorphisms TASK2/KCNK5, NOTCH4 CAT genes pre-term birth) predict individual hypoxia-related sleep-disordered breathing. Currently, polysomnography should first choice evaluate individual’s predisposition decrease related Further interventions, both pharmacological non-pharmacological, might alleviate effects hypoxia those athletes show vulnerable.

Language: Английский

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Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: May 24, 2021

Coordination of cardiovascular and respiratory systems enables a wide range human adaptation depends upon the functional state an individual organism. Hypoxia is known to elicit changes in oxygen carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). The delayed effect high altitude (HA) acclimatization on CRC mountaineers remains unknown. objective this study was compare acute hypercapnia before after HA expedition. Nine trained male were investigated at sea level (Pre-HA) 20-day sojourn altitudes 4,000–7,000 m (Post-HA) three states (Baseline, Hypercapnic Rebreathing, Recovery). A principal component (PC) analysis performed evaluate CRC. number with one PC increased Post-HA (nine out nine), compared Pre-HA (five nine) [Chi-square (df = 1) 5.14, P 0.023]; percentage total variance explained by PC1 [Pre-HA median 65.6 (Q1 64.9/Q3 74.9), 75.6 (73.3/77.9), 0.028]. Post-HA, loadings expired fraction O2, CO2, ventilation onto did not change, loading heart rate 0.64 (0.45/0.68) 0.76 (0.65/0.82), 0.038]. During Recovery, higher than during Baseline. there correlation between Exercise addiction scores eigenvalues ( r 0.9, 0.001). Thus, hypercapnic exposure reveals increase coordination, which highly related exercise addiction.

Language: Английский

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Effects of sex differences on breath-hold diving performance

Respiratory Physiology & Neurobiology, Journal Year: 2021, Volume and Issue: 293, P. 103721 - 103721

Published: June 18, 2021

Language: Английский

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The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life

Frontiers in Pediatrics, Journal Year: 2022, Volume and Issue: 10

Published: Oct. 26, 2022

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether attenuation persists into second year life. We investigated at 12-15 months corrected postnatal age assessed predictors a blunted those born very (<32 weeks gestation).HVR was measured infants preterm. Hypoxia induced with three-step reduction their fraction inspired oxygen (FIO2) from 0.21 to 0.14. Respiratory frequency (f), tidal volume (VT), minute ventilation (VE), inspiratory time (tI), expiratory (tE), VT/tI, tI/tTOT, VT/tTOT, area under low-volume loop peak flow (PTEF) were first third each FIO2. The change respiratory variables over using repeated measures ANOVA Greenhouse-Geisser correction. A defined as <10% rise VE, normoxia. relationship between factors magnitude Spearman correlation.Thirty nine demonstrated mean (SD) 11.4 (10.1)% (increase VE) decreasing FIO2 However, 17 (44%) failed increase VE by ≥10% (range -14% 9%) considered have hypoxia. Males had smaller than females [ΔVE (-9.1%; -15.4, -2.8; p = 0.007)].Infants surviving an hypoxia that life, especially males.

Language: Английский

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Arterial desaturation rate does not influence self‐selected knee extension force but alters ventilatory response to progressive hypoxia: A pilot study

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 1, 2024

Abstract The absolute magnitude and rate of arterial desaturation each independently impair whole‐body aerobic exercise. This study examined potential mechanisms underlying the rate‐dependent relationship. Utilizing an exercise protocol involving unilateral, intermittent, isometric knee extensions (UIIKE), we provided sufficient reperfusion time between contractions to reduce accumulation intramuscular metabolic by‐products that typically stimulate muscle afferents. objective was create a milieu conducive accentuating any influence on muscular fatigue. Eight participants completed four UIIKE sessions, performing one 3 s contraction every 30s at perceived intensity 50% MVC for 25 min. Participants voluntarily adjusted their force generation maintain perceptual effort without feedback. Reductions in inspired oxygen fraction (F I O 2 ) decreased saturation from >98% 70% with varying rates three trials: FAST (5.3 ± 1.3 min), MED (11.8 2.7 SLOW (19.9 3.7 min). F remained 0.21 during control trial. Force activation baseline levels throughout trials, unaffected by or desaturation. Minute ventilation increased hypoxia ( p < 0.05), faster magnified this response. These findings demonstrate affect ventilation, but do not fatigue development UIIKE.

Language: Английский

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