Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 17, 2023
Background:
Polypharmacy,
defined
as
the
simultaneous
use
of
multiple
medications
by
a
patient,
is
worldwide
problem
rising
prevalence.
Paving
way
for
drug
interactions,
adverse
reactions
and
non-adherence,
it
leads
to
negative
health
outcomes,
increased
healthcare
services
costs.
Since
closely
related
multimorbidity,
peaks
in
older
adults.
So
far,
not
many
polypharmacy
management
programs
elderly
have
been
introduced
practice.
However,
due
rapid
ageing
European
societies,
there
an
urgent
need
implement
them
more
widely.
Objective:
The
aim
this
study
was
benchmark
available
Europe
creating
dedicated
benchmarking
application.
Methods:
It
cross-sectional
based
on
online
survey
targeting
professionals
other
stakeholders
across
countries.
Data
collected
were
reused
design
Results:
As
911
respondents
from
all
but
two
EU
countries
took
part
study.
Out
participants,
496
(54.4%)
reported
availability
various
activities
or
formal
that
known
them.
These
had
goals,
which
improved
patient
safety
indicated
most
common
objective
(65.1%
cases).
typical
settings
such
primary
care
(49.4%),
with
pharmacists
doctors
being
often
those
providing
(61.7%
35.5%
cases,
respectively).
Vast
majority
applied
diverse
forms
reviews.
identified
assessed
against
four
predefined
dimensions
effectiveness,
applicability,
scalability
cost-effectiveness.
lowest
scores
obtained
within
last
these
categories,
unavailability
relevant
data.
Based
results,
application
constructed.
allows
comparing
individual
program
ones,
particularly,
national
context.
Conclusion:
By
strong
evidence,
findings
study,
coupled
application,
can
prove
valuable
aiding
clinicians
policymakers
implementation
expansion
elderly.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(7), P. e28410 - e28410
Published: March 21, 2024
Higher
entrepreneurial
traits
significantly
increase
the
likelihood
of
graduate
students
venturing
into
entrepreneurship.
This
study
intended
to
develop
a
scale
for
assessing
students,
recognizing
gap
in
existing
literature
and
measurement
tools
predominantly
developed
countries
with
conducive
climates.
Aligned
Ajzen's
theory
planned
behavior,
employed
modified
Delphi
method,
including
prototype
development,
two
surveys,
subsequent
statistical
analyses.
The
robustness
final
items
effectively
capturing
is
supported
by
descriptive
analyses
(SD
≤
1.5,
Interquartile
Range
≤1,
Level
Agreement
≥70%),
content
validity
analysis
(I-CVI≥
0.8,
S-CVI/Ave
=
0.92;
S-CVI/UA
0.4),
Kendall's
Coefficient
Concordance
(X2
(37,
N
30)
700.504,
W
0.631,
p
<
0.01).
Ultimately,
comprises
38
organized
three
overarching
thematic
areas:
life
philosophy,
creating
utilizing
mindset,
supportive
motivating
environment.
Consistent
literature,
are
intricately
linked
individuals'
perspectives,
often
characterized
desire
self-autonomy.
Additionally,
ability
create
or
leverage
available
resources
presence
external
environment
emerge
as
pivotal
dimensions
traits.
Notably,
highlights
critical
influence
country's
policies,
mainly
through
university
courses
short-term
programs,
shaping
development
Frontiers in Medicine,
Journal Year:
2018,
Volume and Issue:
5
Published: May 8, 2018
Challenges
posed
by
demographic
changes
and
population
aging
are
key
priorities
for
the
Horizon
2020
Program
of
European
Commission.
Aligned
with
vision
Innovation
Partnership
on
Active
Healthy
Ageing
(EIP
AHA),
development,
exchange,
large-scale
adoption
innovative
good
practices
is
a
element
responses
required
to
ensure
all
citizens
remain
as
active
healthy
possible
they
age.
Urged
need
developing
scalable
disruptive
innovation
across
Europe,
Commission
EIP
AHA
created
Reference
Sites;
local
coalition
partners
that
develop
support
AHA.
Ageing@Coimbra
an
example
how
this
can
be
achieved
at
regional
level.
The
consortium
comprises
over
70
institutions
in
Portugal.
network
stakeholders
build
holistic
ecosystem
health
social
care,
taking
into
consideration
specificities
territories,
living
environments
cultural
resources
(2,243,934
inhabitants,
530,423
aged
65
or
plus
live
Centre
Region
Portugal).
Good
reducing
burden
brain
diseases
affect
cognition
memory
impairment
older
people
tackling
isolation
urban
rural
areas
among
top
Ageing@Coimbra.
Profiting
from
collaborative
work
academia,
business
companies,
civil
society,
authorities,
quadruple
helix
supports:
early
diagnosis
frailty
disease;
care
cure;
active,
assisted,
independent
living.
This
paper
describes,
Community
Case
Study,
creation
Site
AHA,
Ageing@Coimbra,
its
impact
motivate
other
regions
formulas
federate
networks,
building
consortia
growing
movement,
inspired
concept
replication
practices;
creating
new
Sites
benefit
Citizens.
First Language,
Journal Year:
2021,
Volume and Issue:
42(4), P. 552 - 578
Published: Nov. 30, 2021
Shared
book
reading
in
preschool
settings
plays
an
influential
role
supporting
children’s
oral
language
and
emergent
literacy
skills.
Early
childhood
teachers
can
provide
high-quality
shared
experiences
using
extratextual
utterances
(reading
beyond
the
story
text)
to
maximise
these
learning
outcomes.
We
report
on
development
psychometric
properties
of
‘Emergent
Literacy
Language
Childhood
Checklist
for
Teachers’
(ELLECCT)
tool,
a
comprehensive
observational
checklist
designed
document
early
teachers’
strategies
during
reading.
The
ELLECCT
measures
dialogic
prompts,
vocabulary
promotion
strategies,
responsive
statements,
print
knowledge
phonological
awareness.
also
contains
rating
scale
examining
paralinguistic
nonverbal
used
by
support
engagement
interactions.
were
measured
four-phase
process.
Content
validity
was
tested
Validity
Index
three-round
Delphi
process
measure
face
validity.
Both
intra-rater
inter-rater
reliability
evaluated
from
sample
32
observations.
study
findings
preliminary
evidence
ELLECCT,
such
that
it
is
judged
as
suitable
evaluation
use
while
engaged
describe
ELLECCT’s
potential
application
both
classroom
coaching
training,
research
skill-development
Journal of Neuroendocrinology,
Journal Year:
2022,
Volume and Issue:
35(1)
Published: Dec. 7, 2022
The
stomach-derived
octanoylated
peptide
ghrelin
was
discovered
in
1999
and
recognized
as
an
endogenous
agonist
of
the
growth
hormone
secretagogue
receptor
(GHSR).
Subsequently,
has
been
shown
to
play
key
roles
controlling
not
only
secretion,
but
also
a
variety
other
physiological
functions
including,
limited
to,
food
intake,
reward-related
behaviors,
glucose
homeostasis
gastrointestinal
tract
motility.
Importantly,
non-acylated
form
ghrelin,
desacyl-ghrelin,
can
be
detected
biological
samples.
Desacyl-ghrelin,
however,
does
bind
GHSR
at
levels,
its
role
remained
less
well-characterized
than
that
ghrelin.
Ghrelin
desacyl-ghrelin
are
currently
referred
literature
using
many
different
terms,
highlighting
need
for
consistent
nomenclature.
variability
terms
used
designate
lead
confusion,
miscommunication,
especially
those
who
familiar
with
literature.
Thus,
we
conducted
survey
among
experts
have
contributed
aiming
identify
whether
consensus
may
reached.
Based
on
results
this
consensus,
propose
"ghrelin"
"desacyl-ghrelin"
refer
itself
form,
respectively.
further
"GHSR"
receptor,
"LEAP2"
liver-expressed
antimicrobial
2,
recently
antagonist/inverse
agonist.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 17, 2023
Background:
Polypharmacy,
defined
as
the
simultaneous
use
of
multiple
medications
by
a
patient,
is
worldwide
problem
rising
prevalence.
Paving
way
for
drug
interactions,
adverse
reactions
and
non-adherence,
it
leads
to
negative
health
outcomes,
increased
healthcare
services
costs.
Since
closely
related
multimorbidity,
peaks
in
older
adults.
So
far,
not
many
polypharmacy
management
programs
elderly
have
been
introduced
practice.
However,
due
rapid
ageing
European
societies,
there
an
urgent
need
implement
them
more
widely.
Objective:
The
aim
this
study
was
benchmark
available
Europe
creating
dedicated
benchmarking
application.
Methods:
It
cross-sectional
based
on
online
survey
targeting
professionals
other
stakeholders
across
countries.
Data
collected
were
reused
design
Results:
As
911
respondents
from
all
but
two
EU
countries
took
part
study.
Out
participants,
496
(54.4%)
reported
availability
various
activities
or
formal
that
known
them.
These
had
goals,
which
improved
patient
safety
indicated
most
common
objective
(65.1%
cases).
typical
settings
such
primary
care
(49.4%),
with
pharmacists
doctors
being
often
those
providing
(61.7%
35.5%
cases,
respectively).
Vast
majority
applied
diverse
forms
reviews.
identified
assessed
against
four
predefined
dimensions
effectiveness,
applicability,
scalability
cost-effectiveness.
lowest
scores
obtained
within
last
these
categories,
unavailability
relevant
data.
Based
results,
application
constructed.
allows
comparing
individual
program
ones,
particularly,
national
context.
Conclusion:
By
strong
evidence,
findings
study,
coupled
application,
can
prove
valuable
aiding
clinicians
policymakers
implementation
expansion
elderly.