Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Language: Английский

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Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy—An Overview on Recent Advances

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 533 - 533

Published: Feb. 27, 2022

Due to complicated anatomical and physical properties, targeted drug delivery ocular tissues continues be a key challenge for formulation scientists. Various attempts are currently being made improve the in vivo performance of therapeutic molecules by encapsulating them various nanocarrier systems or devices administering via invasive/non-invasive minimally invasive administration methods. Biocompatible biodegradable lipid nanoparticles have emerged as potential alternative conventional overcome barriers. Lipid-based led major technological advancements advantages during last few decades therapy, such high precorneal residence time, sustained release profile, minimum dosing frequency, decreased toxicity, site delivery, and, therefore, an improvement bioavailability. In addition, formulations can given fine dispersion patient-friendly droppable preparation without causing blurred vision sensitivity reactions. The unique nanoparticles, namely, solid nanostructured carriers, nanoemulsions, liposomes intraocular drugs extensively discussed. Ongoing completed clinical trials liposome-based characterization techniques designed nanoemulsion tabulated. This review also describes diverse nanoparticle methods, procedures, advantages, limitations. Functionalization approaches drawbacks well exploration new functional additives with penetration macromolecular pharmaceuticals, would quickly progress challenging field systems.

Language: Английский

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Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation and In Vivo Studies

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(4), P. 523 - 523

Published: April 9, 2021

Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated prospects drug-loaded SLNs increase permeation and improve therapeutic potential clarithromycin in therapy. were formulated by high-speed stirring ultra-sonication method. Solubility studies carried out select stearic acid former, Tween 80 surfactant, Transcutol P cosurfactant. Clarithromycin-loaded SLN optimized fractional factorial screening 32 full designs. Optimized (CL10) evaluated for stability, morphology, permeation, irritation, pharmacokinetics rabbits. Fractional design signifies that sonication time amount affect formulation. A established both factors had significant influences on particle size, percent entrapment efficiency, drug loading SLNs. The release profile (CL9) showed ~80% 8 h followed Weibull model kinetics. significantly higher (30.45 μg/cm2/h; p < 0.0001) compared control (solution). CL10 spherical shape good stability was found non-irritant administration. Pharmacokinetics data demonstrated improvement (p from CL10, evidenced a 150% Cmax (~1066 ng/mL) 2.8-fold AUC (5736 ng h/mL) solution (Cmax; 655 ng/mL AUC; 2067 h/mL). In summary, observed here demonstrate developed clarithromycin, hence could be viable delivery approach treat endophthalmitis.

Language: Английский

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Formulation and Evaluation of Moxifloxacin Loaded Bilosomes In-Situ Gel: Optimization to Antibacterial Evaluation

Gels, Journal Year: 2022, Volume and Issue: 8(7), P. 418 - 418

Published: July 4, 2022

In this study, moxifloxacin (MX)-loaded bilosome (BS) in situ gel was prepared to improve ocular residence time. MX-BSs were using the thin-film hydration method. They optimized a Box−Behnken design (BBD) with bile salt (A, sodium deoxycholate), an edge activator (B, Cremophor EL), and surfactant (C, Span 60) as process variables. Their effects assessed based on hydrodynamic diameter (Y1), entrapment efficacy (Y2), polydispersity index (Y3). The formulation (MX-BSop) depicted low (192 ± 4 nm) high efficiency (76 1%). Further, MX-BSop successfully transformed into chitosan alginate carriers. (MX-BSop-Ig4) further evaluated for gelling capacity, clarity, pH, viscosity, vitro release, bio-adhesiveness, ex vivo permeation, toxicity, antimicrobial properties. MX-BSop-Ig4 exhibited optimum viscosity of 65.4 5.3 cps sol 287.5 10.5 states. sustained release profile (82 4% 24 h) achieved Korsmeyer−Peppas kinetic model (R2 = 0.9466). Significant bio-adhesion (967.9 dyne/cm2) tear film. It also 1.2-fold 2.8-fold higher permeation than MX-Ig pure MX solution, respectively. did not show any toxicity tested tissue, confirmed by corneal (77.3%), cornea histopathology (no internal changes), HET-CAM test (zero score). significantly (p < 0.05) effect against Staphylococcus aureus Escherichia coli. findings suggest that is good alternative increase time, well therapeutic activity.

Language: Английский

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Development and optimization of in-situ gel containing chitosan nanoparticles for possible nose-to-brain delivery of vinpocetine

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127217 - 127217

Published: Oct. 3, 2023

Language: Английский

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Quetiapine Fumarate-Loaded Mixed Micelles in Nasal In-Situ Gels: Enhancing Efficacy for Schizophrenia Management

Next research., Journal Year: 2025, Volume and Issue: unknown, P. 100234 - 100234

Published: March 1, 2025

Language: Английский

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Wound healing potential of insulin-loaded nanoemulsion with Aloe vera gel in diabetic rats

Journal of Drug Delivery Science and Technology, Journal Year: 2021, Volume and Issue: 64, P. 102601 - 102601

Published: May 26, 2021

Language: Английский

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Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ tacrolimus gel

Journal of Biomaterials Science Polymer Edition, Journal Year: 2021, Volume and Issue: 32(13), P. 1678 - 1702

Published: May 20, 2021

To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, sustain release drug. The PL-CS optimized using 2-factor-3-level central composite experimental design by selecting concentration PL CS as independent variables while gelation time, temperature, spreadability dependent variables. formulation developed 22.5 g 0.3 CS, gels at 33.6 °C, 22.93 s, showed 6.2 cm. In vitro studies conducted for revealed sustained TCS (81.73% 4 h) improved corneal permeation (74.13% h), compared solution. mechanism followed Higuchi model Fickian diffusion transport. Further, histopathology HET-CAM that non-irritating safe ocular administration.

Language: Английский

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Gel-Based Materials for Ophthalmic Drug Delivery

Gels, Journal Year: 2021, Volume and Issue: 7(3), P. 130 - 130

Published: Aug. 29, 2021

The most common route of administration ophthalmic drugs is the topical because it convenient, non-invasive, and accessible to all patients. Unfortunately, administered topically are not able reach effective concentrations. Moreover, their bioavailability must be improved decrease frequency administrations side effects, increase therapeutic efficiency. For this purpose, in recent decades, particular attention has been given possibility developing prolonged-release forms that precorneal residence time loss drug due tearing. Among these forms, gel-based materials have studied as an ideal delivery system they extremely versatile class with numerous prospective applications ophthalmology. These used gel eye drops, situ gelling formulations, intravitreal injections, contact lenses. This review intended describe main

Language: Английский

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Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies

Gels, Journal Year: 2022, Volume and Issue: 8(6), P. 342 - 342

Published: May 30, 2022

The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low perfusion drug to brain. objective current investigation was design and develop an situ mucoadhesive gel loaded with darunavir assess feasibility brain targeting through intranasal route. Preliminary batches (F1−F9) were prepared evaluated for various pharmaceutical characteristics. A full factorial experiment applied optimize effect two influencing variables (Carbopol 934P (X1) Poloxamer 407 (X2)) on response effects (gelation temperature (Y1) % release (Y2) at 8 h). data demonstrate that both affect significantly (p < 0.05). optimized formulation (F7) exhibited favorable rheological properties, adequate mucoadhesion, sustained release, greater permeation across nasal mucosa. An vitro ciliotoxicity study confirms nontoxicity (D7) vivo pharmacokinetic rats performed following application selected (D7). Significantly higher 0.0001) Cmax (~4-fold) AUC0-α (~3.5-fold) values noticed after application, as compared intravenous However, less systemic exposure therapy, which absorption into central compartment. Overall, here effective route could be a viable option treatment NeuroAIDS.

Language: Английский

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