Gender Differences in Cortisol and Cortisol Receptors in Depression: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7129 - 7129

Published: April 12, 2023

Stress is known to have a significant impact on mental health. While gender differences can be found in stress response and disorders, there are limited studies the neuronal mechanisms of Here, we discuss cortisol depression as presented by recent clinical studies, well role glucocorticoid receptors (GRs) mineralocorticoid (MRs) stress-associated disorders. When examining drawn from PubMed/MEDLINE (National Library Medicine) EMBASE, salivary generally showed no correlation. However, young males were reported show heightened reactivity compared females similar age depression. Pubertal hormones, age, early life stressors, types bio-samples for measurement affected recorded levels. The GRs MRs HPA axis could different between during depression, with increased activity upregulated MR expression male mice, while inverse happened female mice. functional heterogeneity imbalance brain may explain This knowledge understanding will support development gender-specific diagnostic markers involving

Language: Английский

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Quality of life during COVID-19 pandemic: a community-based study in Dakahlia governorate, Egypt

Global Health Research and Policy, Journal Year: 2022, Volume and Issue: 7(1)

Published: May 19, 2022

The sudden transmission of the novel coronavirus along with instant measures taken in response to Coronavirus Disease 2019 (COVID-19) pandemic caused many new challenges adversely disturbing quality life (QoL). objective this study is measure public during COVID-19 and factors affecting it among adults.

Language: Английский

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Prevalence of and risk factors for depression, anxiety, and stress in non-hospitalized asymptomatic and mild COVID-19 patients in East Java province, Indonesia

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(7), P. e0270966 - e0270966

Published: July 7, 2022

Background Despite abundant data on mental health during the COVID-19 pandemic, 3 important knowledge gaps continue to exist, i.e., 1) studies from low-/middle income countries (LMICs); 2) in later period of pandemic; and 3) non-hospitalized asymptomatic mild patients. To address gaps, we assessed prevalence risk factors for symptoms among patients one LMIC (Indonesia) pandemic. Methods This cross-sectional study was conducted September 2020 East Java province, Indonesia. Study population consisted who were diagnosed based reverse transcriptase-polymerase chain reaction results nasopharyngeal swab. Mental evaluated using Depression Anxiety Stress Scale-21. Results From 778 patients, 608 included analysis. Patients’ median age 35 years old 61.2% male. Of these, 22 (3.6%) reported depression, 87 (14.3%) anxiety, 48 (7.9%) stress. Multivariate logistic regression analysis showed that females more likely report stress (adjusted odds ratio (aOR) = 1.98, p-value 0.028); healthcare workers depression anxiety (aOR 5.57, 0.002 aOR 2.92, 0.014, respectively); those with a recent history self-quarantine 5.18, p 0.004 1.86, 0.047, respectively). Conclusion The symptoms, especially relatively low pandemic In addition, several have been identified.

Language: Английский

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Mental health outcomes and psychosocial hazards experienced by construction professionals with different demographic characteristics during the COVID-19 pandemic

Engineering Construction & Architectural Management, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Purpose The COVID-19 pandemic and the corresponding control measures have harmed mental health of professionals working in construction industry. Existing research has also indicated that demographic characteristics are leading variables causing differences individual’s perceptions on psychosocial hazardous factors. Combining these, this aims to compare similarities perceived outcomes hazards among with different during pandemic. Design/methodology/approach Using a questionnaire survey, data were collected from 531 Chinese companies, which analyzed quantitatively using mean score comparative analysis, Mann–Whitney U test Kruskal–Wallis H test, as well Spearman’s correlation analysis. Findings results indicate ages, years experience positions exposed hazards, resulting conditions Age strong predictors level depression anxiety experienced by professionals; is, ill tends decrease increase age experience. Male department/unit heads, company office environment for private aged 31–40 old 11–20 experience, tend best condition. In contrast, more likely produce most serious impact male site-based state-owned company, either less than one year or senior management position. Originality/value Despite significant contribution industry global economy, remain unknown. This research, therefore, reveals hazard impacts types Specifically, unveils important personal closely associated poor stronger valuable governments companies formulate targeted intervention strategies future public emergencies.

Language: Английский

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Impact of emerging COVID-19 variants on psychosocial health: A systematic review

Journal of Family Medicine and Primary Care, Journal Year: 2025, Volume and Issue: 14(2), P. 514 - 520

Published: Feb. 1, 2025

The COVID-19 pandemic has had significant psychological effects on individuals and communities around the world. Studies have found that prevalence of anxiety depression symptoms increased significantly during pandemic. goal study is to understand how emerging new virus variants keep world in a state fear mental health measures can be implemented adopted alleviate anxiety. A broad search for observational studies was carried out Pubmed, Google Scholar, Clinical Key, World Medical Library. reported and/or related existence generated by suffering or not from diseases caused viruses which full text article accessible were included study, while systematic review meta-analysis groups excluded. However, 22 review. deleterious psychosocial restructuring life, establishment unhealthy habits, emergence "corona phobia", stigma being afflicted with disease spreading it loved ones, lack contact others. Increased rates also seen. circulating responsible these main repercussions Epsilon, Zeta, Eta, Iota, Kappa, Alpha, Beta, Gamma, Delta. Social support protective. There critical need comprehensive approach addressing only physiological well-being an individual but their pave way society resilient face current as well future pandemics.

Language: Английский

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Impact of Long COVID on Health-Related Quality of Life Among COVID-19 Survivors in Saudi Arabia

Healthcare, Journal Year: 2025, Volume and Issue: 13(8), P. 890 - 890

Published: April 12, 2025

Background: Long COVID (LC) has emerged as a significant epidemiological and public health issue, affecting patients’ health-related quality of life (HRQoL). This study explored the impact LC on HRQoL in COVID-19 survivors Eastern Province Saudi Arabia examined sociodemographic clinical factors that influence HRQoL. Methods: cross-sectional included 1024 participants, data were collected through face-to-face interviews using structured questionnaire incorporated EQ-5D-5L tool to assess Sociodemographic information, acute symptoms, symptoms recorded. Statistical analyses bivariate multivariable generalized linear modelling. Results: Of all 63.8% reported experiencing with fatigue, cough, anosmia being most common. Participants had significantly lower scores (mean index score, 0.93) than those without 0.98; p < 0.001). The key influencing higher number older age, presence pneumonia during COVID-19, pre-existing conditions such anxiety hypertension. Conclusions: negatively impacts HRQoL, chronic diseases, strong predictors poor outcomes. Interventions targeting rehabilitation psychosocial support are critical for improving long-term outcomes patients LC.

Language: Английский

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Debate on mandatory COVID-19 vaccination

Ethics Medicine and Public Health, Journal Year: 2022, Volume and Issue: 21, P. 100761 - 100761

Published: Jan. 24, 2022

Language: Английский

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The resources to balance – Exploring remote employees’ work-life balance through the lens of conservation of resources

Cogent Business & Management, Journal Year: 2023, Volume and Issue: 10(2)

Published: July 11, 2023

The aim of this study is to investigate how employees' work-life balance (WLB) can be supported by various resources, and what mechanisms steer the use these resources achieve WLB. research based on Conservation Resources (COR) theory a multidimensional construct Casper et al. (2018). Through thematic analysis 89 semi-structured interviews with remote workers, identified three key that support ability maintain WLB: flexible work arrangements, autonomous work, time saving. More importantly, results revealed steered their self-efficacy, as well experiences trust from supervisors. contributes work-family providing comprehensive understanding it in working context. findings emphasize importance promoting agency building WLB enhancement individuals' self-efficacy. It suggested employers should ensure supervisors facilitate rather than hinder process. Therefore, important establish common principles for avoid discrepancies individual supervisors' judgments personal preferences.

Language: Английский

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COVID-19 may lower quality of life when infections and deaths increase: A longitudinal study in the Peruvian jungle

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: March 28, 2023

Quality of life (QoL) is a multifactorial concept on the perception individual's wellbeing underpinned by environmental, psychological, and physical factors. Several studies have shown changes in QoL COVID-19 pandemic may be due to increases mortality rates, however, no study has investigated this among Peruvian jungle dwellers. Here, we sought estimate individuals before after increase cases deaths from COVID-19.A questionnaire-based longitudinal was conducted 102 inhabitants (mean 40.75 ± 7.49 years). The Spanish version WHOQOL-BREF used two stages: April June. first stage accomplished confirmed case COVID-19, second when daily rate 3.5% with an incidence 87%.Sixty (54.8%) participants were women, 67 (61.9%) >31 years, 38 (34.5%) 32 (29.1%) had primary secondary education, respectively. In obtained overall mean 46.65 23.2 35 27.7 points, Individuals significantly lower face increased (p = 0.001), mental 0.028) environmental 0.001) health domains, latter having greatest impact (51.84 5.81 vs. 16.66 5.55 points).Quality dwellers reduced during periods COVID-19. Preventive strategies aimed at reducing global living Amazon are recommended authorities.

Language: Английский

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Empirical evidence to understand the human factor for effective rapid testing against SARS-CoV-2

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(32)

Published: Aug. 6, 2021

Significance Rapid testing with antigen tests accompanies efforts for controlling the disease dynamics in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. A high willingness to carry out these and test literacy of potential users are needed. In four cross-sectional data collections more than 4,000 participants, we showed that incentives can increase undertake a test, while mandatory reporting was not perceived as major barrier. However, participants had difficulties correctly interpreting results. short health communication intervention effectively reduced complacent behavior after negative sum, rapid have great help fight SARS-CoV-2 pandemic but only when effective enables people act appropriately.

Language: Английский

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