Time to recovery of COVID-19 patients and its predictors: a retrospective cohort study in HUCSH, Sidama, Ethiopia

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 7, 2025

The 2019 COVID-19 pandemic had a global impact, leading to numerous deaths, long recovery times, and economic challenges worldwide, especially in countries with limited financial resources like Ethiopia. In Ethiopia, Hawassa lacks viral shedding information. Identifying predictors can help ease impact of illness.Therefore, this research aimed examine the demographics, clinical features, time patients, as well determine predictive markers for severe adverse outcomes. Study at University Comprehensive Speciality Hospital quarantine therapy facility Ethiopia (Sep 24, 2020 - Nov 26, 2021) 804 patients. Extracted clinical, epidemiological, demographic info from medical records. Researchers used statistical tests T tests, Chi-square Fisher's exact analyze relationships between variables. They also Cox PH model identify risk factors patient time. Significance level was set 0.05 all analyses. Out 74% recovered an average age 44.8 years, 64.1% being male. Severe critical cases were 24.1% 21.4% population, respectively, only 16.0% 19.5% recovering. Average length stay 12.3 days. 88.4% patients symptoms, chest pain (66.7%), cough (64.4%), shortness breath (59.2%), fever (57.1%) common. Nearly half comorbidities, diabetes (15.9%) hypertension (15.2%) prevalent. Male higher rates, while severe/critical lower rates. Patients over 39 category chance. Existence least one diabetes, fever, impacted recovery. Fever gender affected Assumptions met no multicollinearity. Recent studies found that about 95% recover within 30 days, median 12 cases, elderly, those comorbidities may take longer recover. By effectively managing individuals improve their prognosis facilitate quicker Public health concerns persist regarding COVID-19, diabetic hypertension. Early detection treatment expedite

Language: Английский

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Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil

Emerging infectious diseases, Journal Year: 2023, Volume and Issue: 29(1), P. 26 - 35

Published: Jan. 1, 2023

Abstract Down syndrome is the most common human chromosomal disorder. Whether a risk factor for severe COVID-19 outcomes in pediatric patients remains unclear, especially low-to-middle income countries. We gathered data on <18 years of age with SARS-CoV-2 infection from national registry Brazil to assess among syndrome. included 14,684 hospitalized patients, 261 whom had After adjustments sociodemographic and medical factors, 1.8 times higher odds dying (odds ratio 1.82, 95% CI 1.22–2.68) 27% longer recovery (hazard 0.73, 0.61–0.86) than without found was associated increased illness death patients. Guidelines managing could improve this population.

Language: Английский

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Influenza and COVID-19 co-infection and vaccine effectiveness against severe cases: a mathematical modeling study

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 4, 2024

Background Influenza A virus have a distinctive ability to exacerbate SARS-CoV-2 infection proven by in vitro studies. Furthermore, clinical evidence suggests that co-infection with COVID-19 and influenza not only increases mortality but also prolongs the hospitalization of patients. is small-scale recurrent epidemic, increasing likelihood co-epidemic seasonal influenza. The impact on population remains unstudied. Method Here, we developed an age-specific compartmental model simulate co-circulation estimate number co-infected patients under different scenarios prevalent type vaccine coverage. To decrease risk developing severity, investigated minimum coverage required for conjunction vaccine, particularly during seasons. Result Compared single transmission exhibits lower trend delayed peak when Number cases higher than B virus. as becomes more transmissible. As proportion individuals vaccinated vaccines increases, severe illnesses illness decreases time delayed, especially those &gt;60 years old. Conclusion minimize arising from COVID-19, vaccinations are important, priority elderly.

Language: Английский

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The prognostic role of micronutrient status and supplements in COVID-19 outcomes: A systematic review

Food and Chemical Toxicology, Journal Year: 2022, Volume and Issue: 162, P. 112901 - 112901

Published: Feb. 25, 2022

Language: Английский

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Leveraging an epidemic–economic mathematical model to assess human responses to COVID-19 policies and disease progression

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 8, 2023

Abstract It is imperative that resources are channelled towards programs efficient and cost effective in combating the spread of COVID-19, disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This study proposed analyzed control strategies for purpose. We developed a mathematical model within an optimal framework allows us to investigate best approach curbing COVID-19 epidemic. address following research question: what role community compliance as measure control? Analyzing impact recommended guidelines health authorities—examples, social distancing, face mask use, sanitizing—coupled with efforts authorities areas vaccine provision quarantine—showed intervention addition implementing vaccination quarantine measures, active incorporation individuals’ collective behaviours, should also be directed campaigns on importance frequent sanitizing, any other activities. demonstrated behavioral response individuals influences dynamics; implying policy contextualized.

Language: Английский

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COVID-19 mortality rate and its determinants in Ethiopia: a systematic review and meta-analysis

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 27, 2024

Background The COVID-19 mortality rate continues to be high in low-income countries like Ethiopia as the new variant’s transmission expands and countries’ limited capacity combat disease causes severe outcomes, including deaths. aim of this study is determine magnitude its determinants Ethiopia. Methods main electronic databases searched were PubMed, CINAHL, Google Scholar, African journals online. included studies’ qualities assessed independently using Newcastle-Ottawa scale. data was extracted Microsoft Excel spreadsheet format. pooled effect size odds ratios with 95% confidence intervals across studies determined random-effects model. I 2 used estimate percentage overall variation due heterogeneity. Egger’s test funnel plot find published bias. A subgroup analysis conducted. a single on estimation by sensitivity analysis. Results total 21 42,307 participants final prevalence 14.44% (95% CI: 10.35–19.08%), significant heterogeneity (I = 98.92%, p &lt; 0.001). risk from higher for patients comorbidity (AHR 1.84, 1.13–2.54) cardiovascular 2, 1.09–2.99) than their counterparts without these conditions. Conclusion number died comorbidities, particularly those disease, should receive special attention reduce mortality. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/ , identifier (ID) CRD42020165740.

Language: Английский

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Predictive factors for osteoporosis in adult spinal deformity patients

Spine Deformity, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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A quantum mechanics-based framework for infectious disease modeling

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Traditional infectious disease models often use fixed compartments to represent different states of individuals. However, these can be limited in accurately reflecting real-world conditions In this study, we integrate quantum mechanics into modeling, developing a mechanics-based model that effectively addresses the limitations traditional compartmental and introduces novel approach understanding dynamics. Firstly, examined individual infection process model's evolutionary dynamics, deriving both disease-free equilibrium point basic reproduction number. Secondly, proposed is simulated on circuit. The simulation results are utilized analyze parameter sensitivity verify its rationality. indicate predictions align with general patterns viral transmission capable replicating structural attributes models. Finally, apply simulate spread COVID-19. observed similarity between actual trends demonstrates effectiveness capturing Comparative experiments show significantly improves accuracy over By leveraging mechanics, our method offers fresh perspective broadening application methodologies information propagation within macroscopic world.

Language: Английский

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Incidence of recovery rate and predictors among hospitalized COVID- 19 infected patients in Ethiopia; a systemic review and meta-analysis

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 3, 2025

Despite global efforts to mitigate COVID-19 infection through vaccination and therapeutic interventions, morbidity mortality rates continued at variable rates. Although risk clinical features of are well-documented, recovery patterns prognostic factors post-admission remain inconclusive, particularly in resource-limited settings like Ethiopia. This systematic review meta-analysis (SRM) aimed estimate the pooled incidence rate predictors among hospitalized patients We searched (N = 1,191) articles using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guideline from PubMed/MEDLINE 755), Scopus 137), Web Science 84), Direct 148), Cochran 25), Google Scholar searching 42) December 2019 February 2024. The data were extracted a Microsoft Excel spreadsheet exported Stata TM version 17.0 further analysis. Article quality was assessed Joanna Briggs Institute checklist. estimated weighted inverse variance random-effects meta-regression. Heterogeneity studies evaluated I2 statistic. Subgroup analyses sensitivity tests also conducted explore publication bias. file is registered international Prospero with ID (CRD42024518569). Sixteen 16) published 7,676 included final report. mean age participants ranged 29 (± 17) 57.5 3) years, male constituting largest proportion participants, 4,491(58.5%). During screening, 6,304(82.21%) cases discharged as improved, 159 (2.1%) attriters, 818 (10.6%) died during inpatient treatment. recovery, mortality, attrition found be 82.32% (95% CI: 78.81-85.83; 94.8%), 14.3% (I2 98.45%), 2.7% 81.34%), respectively. Incidence varied across regions epidemic phases, highest observed Addis Ababa (89.94%, 78.33%) lowest reported Tigray region (59.7%, 0.0%). Across 88.05% 29.56%) Phase II, 84.09% 97.57%) I, 78.92% 96.9%) III, Factors being aged 15-30 years (pooled OR 2.01), sex 1.46), no dyspnea 2.4; 79%), baseline comorbidities 1.15; 89.3%) recovery. CONCLUSION AND RECOMMENDATION: In Ethiopia, more than eight out ten recovered after However, significantly study settings, regions. including younger age, sex, (shortness breathing), underlying comorbidity heightened It highly recommended those inpatients cares should focus on high-risk groups (older adults) implement standardized treatment protocols each setting. Regions lower need aid logistical support training healthcare providers.

Language: Английский

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Recovery and long-term health outcomes of SARS-CoV-2 infection in a prospective cohort in an urban setting, Kenya

Global Health Action, Journal Year: 2025, Volume and Issue: 18(1)

Published: May 30, 2025

Evidence on long COVID remains limited in sub-Saharan countries. This study explored the occurrence of COVID-19-related symptoms and factors affecting recovery severity Nairobi, Kenya. A prospective cohort individuals testing positive for SARS-CoV-2 between February 2022 2023 was followed until June 2023. were assessed every three months. Time to analyzed using survival analysis, while Cox proportional hazard Poisson regression, respectively. Among 291 participants (median age 34, 59.1% female), 42 (14%) had severe/critical infection. At 6 12 months post-positive PCR, 53.1% 33.5% ≥ 1 symptoms, Fatigue (40.2%), pain (36.8%), sore throat headaches (36.4%), loss strength (31.6%) most common. Median time longer cases than mild/moderate (234 vs 206 days, p = 0.016). Participants aged 40-64 years experienced slower those < 40 (aHR 0.635 [95%CI, 0.429;0.941]). with tertiary education recovered faster primary 1.869 1.050;3.327]). Long associated female sex (aIRR 1.418 [95%CI; 1.078;1.864]), (aIRR, 0.489 0.415;0.576]), comorbidity 2.415 1.639;3.559]). Six post-infection, half lingering a third still affected after year. Recovery younger, educated individuals, severe more common women, low pre-existing conditions. The burden Kenya requires support vulnerable groups.

Language: Английский

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