Journal of Biomolecular Structure and Dynamics,
Journal Year:
2022,
Volume and Issue:
41(14), P. 6591 - 6602
Published: Aug. 11, 2022
Bioallethrin
is
an
insecticide
that
widely
used
in
households
resulting
human
exposure.
cytotoxic
to
erythrocytes.
Here
we
have
studied
the
interaction
of
bioallethrin
with
hemoglobin
(Hb)
using
silico
and
biophysical
approaches.
Incubation
Hb
(5
μM)
(1-50
µM)
led
increase
absorbance
at
280
nm
while
Soret
band
406
was
slightly
reduced.
The
intrinsic
fluorescence
enhanced
appearance
a
new
peak
around
305
nm.
Synchronous
showed
binding
mainly
affects
tyrosine
microenvironment.
structural
changes
were
confirmed
significant
shift
CD
spectra
about
25%
loss
α-helix.
Molecular
docking
visualisation
through
Discovery
studio
formation
Hb-bioallethrin
complex
energy
-7.3
kcal/mol.
simulation
stability
dynamics
reaction
between
Hb.
induced
by
inhibition
esterase
activity
In
conclusion,
this
study
shows
forms
stable
which
may
lead
function
body.Communicated
Ramaswamy
H.
Sarma.
Plant Nano Biology,
Journal Year:
2022,
Volume and Issue:
1, P. 100008 - 100008
Published: June 1, 2022
The
use
of
nanotechnology
has
emerged
in
the
agricultural
sector.
In
recent
years,
several
nano-enabled
materials
have
been
reported
for
weed
control.
Nano-enabled
herbicides
(also
called
nanoherbicides)
can
be
designed
from
organic,
inorganic,
or
hybrid
materials.
These
unique
properties
such
as
small
size,
specific
surface
area,
and
ability
to
control
release
metal
ions
organic
molecules
field.
Some
studies
nanoherbicides
provide
better
management
compared
non-nanoformulations.
However,
regarding
environmental
risk
assessment
mechanisms
action
plants
are
still
incipient.
Nevertheless,
they
essential
ensure
a
safe
application
human
health
environment.
this
review,
we
outlined
current
understanding
well
some
strategic
design
fabricate
nanostructures
Also,
critical
discussion
fate,
behavior
effects
was
addressed
order
achieve
products
environmentally
friendly
sustainable
agriculture.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15969 - 15969
Published: Nov. 4, 2023
Pesticides
are
chemicals
used
in
agriculture,
forestry,
and,
to
some
extent,
public
health.
As
effective
as
they
can
be,
due
the
limited
biodegradability
and
toxicity
of
them,
also
have
negative
environmental
health
impacts.
Pesticide
biodegradation
is
important
because
it
help
mitigate
effects
pesticides.
Many
types
microorganisms,
including
bacteria,
fungi,
algae,
degrade
pesticides;
microorganisms
able
bioremediate
pesticides
using
diverse
metabolic
pathways
where
enzymatic
degradation
plays
a
crucial
role
achieving
chemical
transformation
The
growing
concern
about
impacts
pushing
industry
these
products
develop
more
sustainable
alternatives,
such
high
biodegradable
chemicals.
degradative
properties
could
be
fully
exploited
advances
genetic
engineering
biotechnology,
paving
way
for
bioremediation
strategies,
new
technologies,
novel
applications.
purpose
current
review
discuss
that
demonstrated
their
capacity
those
categorized
by
World
Health
Organization
impact
may
on
human
A
comprehensive
list
presented,
enzymes
pesticide
genetics
behind
this
process
discussed.
Due
number
known
capable
degrading
low
described
purpose,
research
must
conducted
field,
genes
yet
discovered
with
possibility
finding
efficient
biodegradation.
Journal of Economic Entomology,
Journal Year:
2023,
Volume and Issue:
116(4), P. 1185 - 1195
Published: June 8, 2023
Insecticide
resistance
is
a
significant
problem
in
insect
management
that
can
result
from
several
processes
including
target-site
change
and
increased
activity
of
detoxifying
enzymes.
Spodoptera
littoralis
one
the
most
resistant
pests.
For
more
effective
management,
alternatives
to
synthetic
pesticides
are
encouraged.
One
these
essential
oils
(EOs).
Cymbopogon
citratus
EO
its
main
constituent
citral
were,
therefore,
considered
this
study.
The
results
revealed
C.
exhibited
larvicidal
against
S.
littoralis,
former
was
insignificantly
toxic
than
latter.
Additionally,
treatments
significantly
affected
detoxification
Cytochrome
P-450
glutathione-S-transferase
were
inhibited,
while
carboxylesterases,
a-esterase
β-esterase,
induced.
molecular
docking
study
indicated
bonded
with
amino
acids
cysteine
(CYS
345)
histidine
(HIS
343)
cytochrome
P-450.
This
suggests
interaction
enzyme
key
mechanism
by
which
act
littoralis.
our
hoped
contribute
better
understanding
action
at
biochemical
levels
provide
safer
efficient
pest
solutions
for
Agronomy,
Journal Year:
2024,
Volume and Issue:
14(6), P. 1260 - 1260
Published: June 11, 2024
Pesticides
play
a
crucial
role
in
agricultural
production
by
preventing
diseases
and
pests
ensuring
food
yield.
However,
the
irrational
use
of
pesticides
can
lead
to
numerous
issues
that
compromise
crop
quality
counteract
original
intentions
their
application.
Therefore,
it
is
necessary
identify
more
effective
methods
pesticide
stress.
Here
we
review
impacts
herbicides,
insecticides,
fungicides
on
plants
measures
taken
reduce
residues
plants.
We
have
found
despite
substantial
differences
mechanisms
action
aforementioned
three
types
pesticides,
adverse
effects
they
inflict
are
similar,
at
certain
dosages,
severely
constrain
plant
growth
disrupt
physiological
functions.
Also,
most
current
research
using
exogenous
regulators
alleviate
stress
still
focuses
photosynthesis,
antioxidant
system,
three-stage
detoxification,
secondary
metabolites,
neglecting
search
for
genes
respond
believe
combining
biological
protection
with
post-harvest
treatment
techniques
exploring
potential
responsive
stress,
better
strategy
dealing
be
found,
thereby
promoting
sustainable
development.
Toxics,
Journal Year:
2023,
Volume and Issue:
11(3), P. 211 - 211
Published: Feb. 24, 2023
Spodoptera
littoralis
(Boisd.)
is
a
prominent
agricultural
insect
pest
that
has
developed
resistance
to
variety
of
insecticide
classes.
In
this
study,
the
three
field
strains
S.
littoralis,
collected
over
consecutive
seasons
(2018
2020)
from
Egyptian
Governorates
(El-Fayoum,
Behera
and
Kafr
El-Shiekh),
six
insecticides
was
monitored.Laboratory
bioassays
were
carried
out
using
leaf-dipping
method
examine
susceptibility
laboratory
tested
insecticides.
Activities
detoxification
enzymes
determined
in
an
attempt
identify
mechanisms.The
results
showed
LC50
values
ranged
0.0089
132.24
mg/L,
corresponding
ratio
(RR)
0.17
4.13-fold
compared
with
susceptible
strain.
Notably,
low
spinosad
all
strains,
very
alpha-cypermethrin
chlorpyrifos.
On
other
hand,
no
methomyl,
hexaflumeron
or
Bacillus
thuringiensis.
The
determination
enzymes,
including
carboxylesterases
(α-
β-esterase),
mixed
function
oxidase
(MFO)
glutathione-S-transferase
(GST),
target
site
acetylcholinesterase
(AChE),
revealed
had
significantly
different
activity
levels
strain.Our
findings,
along
tactics,
are
expected
help
management
Egypt.
Insects,
Journal Year:
2024,
Volume and Issue:
15(7), P. 483 - 483
Published: June 28, 2024
In
this
study,
in
vitro
and
silico
approaches
were
employed
to
assess
the
toxicity
of
marjoram
(Origanum
majorana)
rosemary
(Rosmarinus
officinalis)
essential
oils
(EOs)
A.
ipsilon
larvae.
The
study
determined
activities
ATPases
larvae
after
treatment
with
LC20
LC70
each
EO.
α-esterase
glutathione-S-transferase
(GST)
also
LC10
LC30
Furthermore,
molecular
docking
was
determine
binding
affinity
terpinene-4-ol
α-pinene,
major
constituents
O.
majorana,
R.
officinalis
EOs,
respectively,
compared
co-crystallized
ligand
α-esterase,
diethyl
hydrogen
phosphate
(DPF).
Toxicity
assays
revealed
that
majorana
EO
more
toxic
than
at
96
h
post-treatment.
However,
latter
significantly
inhibited
activity
Na+-K+
pump
almost
all
intervals.
same
concentrations
Mg2+/Ca2+-ATPase
Ca2+
contrast,
showed
a
variable
effect
on
across
different
time
On
other
hand,
both
EOs
varied
effects
GST
over
time.
Molecular
energy
scores
−4.51
−4.29
kcal/mol
for
score
−4.67
PDF.
Our
demonstrated
tested
ipsilon,
suggesting
their
potential
efficacy
as
insecticides.
