Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(09), P. 14560 - 14568
Published: Jan. 1, 2023
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2436 - 2436
Published: July 26, 2024
Adipose tissue (AT), composed mainly of adipocytes, plays a critical role in lipid control, metabolism, and energy storage. Once considered metabolically inert, AT is now recognized as dynamic endocrine organ that regulates food intake, homeostasis, insulin sensitivity, thermoregulation, immune responses. This review examines the multifaceted adiponectin, predominant adipokine released by AT, glucose fatty acid metabolism. We explore regulatory mechanisms its physiological effects potential therapeutic target for metabolic diseases such type 2 diabetes, cardiovascular disease liver disease. Furthermore, we analyze impact various dietary patterns, specific nutrients, physical activities on adiponectin levels, highlighting strategies to improve health. Our comprehensive provides insights into functions importance maintaining systemic homeostasis.
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13452 - 13452
Published: Nov. 3, 2022
Sarcopenia is a disease that becomes more prevalent as the population ages, since it directly linked to process of senility, which courses with muscle atrophy and loss strength. Over time, sarcopenia obesity, being known sarcopenic leads other metabolic changes. At molecular level, organokines act on different tissues can improve or harm sarcopenia. It all depends their production process, associated factors such physical exercise, aging diseases. Because seriousness these repercussions, aim this literature review conduct relationship between organokines, sarcopenia, diabetes, well role exercise. To build review, PubMed-Medline, Embase, COCHRANE databases were searched, only studies written in English included. was observed myokines, adipokines, hepatokines, osteokines had direct impacts pathophysiology its repercussions. Therefore, knowing how very important know age, prevention, they be related prevention loss.
Language: Английский
Citations
31
Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(5), P. 4723 - 4728
Published: March 11, 2023
Language: Английский
Citations
13
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4659 - 4659
Published: April 25, 2024
Adipose tissue is a multifunctional organ that regulates many physiological processes such as energy homeostasis, nutrition, the regulation of insulin sensitivity, body temperature, and immune response. In this review, we highlight relevance different mediators control adipose activity through systematic review main players present in white brown tissues. Among them, inflammatory secreted by tissue, classical adipokines more recent ones, elements system infiltrated into (certain cell types interleukins), well role intestinal microbiota derived metabolites, have been reviewed. Furthermore, anti-obesity promote activation beige e.g., myokines, thyroid hormones, amino acids, both long micro RNAs, are exhaustively examined. Finally, also analyze therapeutic strategies based on those described to date. conclusion, novel regulators obesity, microRNAs or microbiota, being characterized promising tools treat obesity future.
Language: Английский
Citations
4
Russian Pediatric Journal, Journal Year: 2025, Volume and Issue: 28(1), P. 47 - 53
Published: Feb. 28, 2025
Relevance. The prevalence of childhood obesity and its complications determine the need to analyze various mechanisms formation these forms pathology, including disorders that are realized in chronic nonspecific inflammation obesity. aim study was changes levels inflammatory biomarkers obese children their association with disease. Materials methods. There were examined two hundred eleven school-age children, 188 patients constitutionally exogenous 23 conditionally healthy who made up control group. average age 14 years. Anthropometric parameters determined all body mass index (BMI) calculated using Ketle formula, number leukocytes, C-reactive protein erythrocyte sedimentation rate. blood (interleukin (IL)-1β, IL-6, IL-10, IL-18) tumor necrosis factor-α (TNFα) by enzyme immunoassay. Results. Obese metabolic disease showed significantly increased protein, IL-6 when compared without complications. Correlations have been established between High markers indicate obesity-associated early stages Conclusion. patterns can be used as predictors unfavourable course risk
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)
Published: March 12, 2025
Language: Английский
Citations
0
Journal of the Practice of Cardiovascular Sciences, Journal Year: 2025, Volume and Issue: 11(1), P. 35 - 42
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4258 - 4258
Published: July 21, 2024
Acute ischemic stroke (AIS) remains a major cause of mortality and long-term disability worldwide, driven by complex multifaceted etiological factors. Metabolic dysregulation, gastrointestinal microbiome alterations, systemic inflammation are emerging as significant contributors to AIS pathogenesis. This review addresses the critical need understand how these factors interact influence risk outcomes. We aim elucidate roles dysregulated adipokines in obesity, impact gut microbiota disruptions, neuroinflammatory cascade initiated lipopolysaccharides (LPS) AIS. Dysregulated obesity exacerbate inflammatory responses, increasing severity. Disruptions subsequent LPS-induced neuroinflammation further link Advances neuroimaging biomarker development have improved diagnostic precision. Here, we highlight for approach management, integrating metabolic, microbiota, insights. Potential therapeutic strategies targeting pathways could significantly improve prevention treatment. Future research should focus on elucidating developing targeted interventions mitigate impacts metabolic imbalances,
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Sept. 2, 2022
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to a global health outbreak known as the COVID-19 pandemic which has been lasting since March 2020. Vaccine became accessible people only at beginning of 2021 greatly helped reducing mortality rate and severity infection afterwards. The efficacy vaccines was not fully studies documenting immune responses following vaccination are continuing emerge. Recent evidence indicate that natural prior may improve antibody cellular responses, while little is about factors influencing those processes. Here we investigated BNT162b2 in relation previous-infection status age, searched for possible biomarkers associated with observed changes responses. We found caused least 8-times increase titres, effect weaker over 60 years old unaltered by vitamin D serum levels. Furthermore, identified adiponectin positively associate negatively correlate pro-inflammatory molecules (MCP-1, factor D, CRP, PAI-1), especially previously-infected individuals.
Language: Английский
Citations
12
Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 151, P. 109731 - 109731
Published: June 28, 2024
Astaxanthin (AX) is a carotenoid known to have one of the highest documented antioxidant capacities and has attracted considerable scientific commercial interest. The incorporation AX into aquaculture practices been associated with improved pigmentation, modulation immune endocrine systems, stress reduction, reproductive efficiency general fish health. This study describes effects dietary (0, control, 20, 100 500 mg kg
Language: Английский
Citations
2