Communication via female resistance: sexual behavioural modulation and mutual mate choice determinants in a scorpion

Animal Behaviour, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Courtship and distress ultrasonic vocalizations are disrupted in a mouse model of Angelman syndrome

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Background Angelman syndrome (AS) is a single-gene neurodevelopmental disorder caused by loss of function the maternal copy UBE3A gene. Nearly all individuals with AS lack speech, resulting in major impacts on daily life for patients and caregivers. To evaluate new therapies AS, it crucial to have mouse model that characterizes meaningful clinical features. Vocalizations are used many contexts mice, including pup retrieval, social interactions, courtship, distress. Previous work Ube3a m-/p+ found abnormalities number ultrasonic vocalizations (USVs) mice produced during isolation same-sex interactions. Here, we evaluated courtship Quantifying USVs these enables comparison (courtship) non-social (distress) settings. In addition, assessed utility incorporating USV testing into existing behavioral assessments potential treatments. Methods We three-chamber preference test tail suspension distress adult wild-type (WT) littermates, quantified properties using program DeepSqueak. Next, performed an established battery included rotarod, open field, marble burying, nest building. principal component analysis value context other behaviors. Results both nonsocial paradigms, made fewer compared WT mice. Spectral were abnormal but mostly typical test. Including behavior increased distance between clusters space. Conclusions difficulty producing contexts. most impacted context. Adding may improve sensitivity detect group differences changes communication.

Language: Английский

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What matters to a mouse? Effects of internal and external context on male vocal response to female squeaks

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0312789 - e0312789

Published: Feb. 19, 2025

House mice adjust their signaling behavior depending on the social context of an interaction, but which aspects elicit strongest responses from these individuals is often difficult to determine. To explore how internal and external contextual factors influence house produce respond signals, we assessed dominant subordinate male differed in ultrasonic vocalization (USV) production response playback broadband vocalizations (BBVs, or squeaks) when given limited access a stimulus female. We used repeated measures design each was exposed two types trials with different odor conditions: either just female odors (Fem condition) addition potential competitors, other males (Fem+Male condition). The presence this assay served as proxy for “audience” interacted These conditions were replicated distinct cohorts individuals: familiar competitors Fem+Male condition (Familiar cohort), unfamiliar (Unfamiliar cohort). By assessing dominance status focal individual familiarity “audience”, are able may affect one another BBVs. Dominants subordinates did not differ baseline vocal (vocalizations produced prior squeak playback) squeaks. However, all groups, regardless condition, reduced BBV playback. prompted decrease level calling complexity repertoire compared that only included odor, effect also across status. Importantly, individual. findings suggest alter during courtship interactions cues indicate modulated by competitor cues.

Language: Английский

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Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 24, 2024

The context surrounding vocal communication can have a strong influence on how signals are perceived. serotonergic system is well-positioned for modulating the perception of according to context, because neurons responsive social behavior, and innervate auditory regions. Animals like lab mice be excellent models exploring serotonin affects primary neural systems involved in perception, including within central regions inferior colliculus (IC). Within IC, activity reflects not only presence conspecific, but also valence given interaction. To assess whether male mice, we manipulated systemically with an injection its precursor 5-HTP, locally IC infusion fenfluramine, reuptake blocker. Mice then participated behavioral assay which males suppress their ultrasonic vocalizations (USVs) response playback female broadband (BBVs), used defensive aggression by females when interacting males. Both 5-HTP fenfluramine increased suppression USVs during BBV relative controls. additionally decreased baseline production specific type USV investigation, neither drug treatment strongly affected digging or grooming. These findings show that modifies responses part acting brain regions, suggest mouse behavior serve as useful model mechanisms human communication.

Language: Английский

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Autistic‐relevant behavioral phenotypes of a mouse model of cyclin‐dependent kinase‐like 5 deficiency disorder

Autism Research, Journal Year: 2024, Volume and Issue: 17(9), P. 1742 - 1759

Published: Sept. 1, 2024

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene and characterized early-onset epilepsy, intellectual disability, autistic features. To date, etiological mechanisms underlying CDD are largely unknown no effective therapies available. The Cdkl5 knock-out (KO) mouse has been broadly employed preclinical studies on CDD; Cdkl5-KO mice display neurobehavioral abnormalities recapitulating most symptoms, including alterations motor, sensory, cognitive, social abilities. However, available have carried out adult mice, so little known about phenotypic characteristics of this model earlier during development. Furthermore, major autistic-relevant phenotypes, for example, communication deficits, poorly investigated mostly male mutants. Here, we assessed behavioral phenotypes first three post-natal weeks adulthood. Males females were tested, latter both heterozygous homozygous mutant pups showed qualitative quantitative ultrasonic communication, detected at 2 age confirmed later Increased levels anxiety-like behaviors observed mutants 3 adulthood, when stereotypies, reduced interaction memory deficits also observed. These effects mutation evident sexes, being more marked varied than females. findings provide novel evidence profile model, thus supporting its use future investigating pathology autism spectrum disorders.

Language: Английский

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Ultrasonic vocalisation rate tracks the diurnal pattern of activity in winter phenotype Djungarian hamsters (Phodopus sungorus)

Journal of Comparative Physiology B, Journal Year: 2024, Volume and Issue: 194(3), P. 383 - 401

Published: May 11, 2024

Abstract Vocalisations are increasingly being recognised as an important aspect of normal rodent behaviour yet little is known how they interact with other spontaneous behaviours such sleep and torpor, particularly in a social setting. We obtained chronic recordings the vocal adult male female Djungarian hamsters ( Phodopus sungorus ) housed under short photoperiod (8 h light, 16 dark, square wave transitions), different contexts. The animals were kept isolation or same-sex sibling pairs, separated by grid which allowed non-physical interaction. On approximately 20% days spontaneously entered state metabolic depression that coincides rest phase many small mammal species response to actual predicted energy shortages. Animals produced ultrasonic vocalisations (USVs) peak frequency 57 kHz both asocial conditions there was high degree variability vocalisation rate between subjects. Vocalisation correlated locomotor activity across 24-h light cycle, occurring more frequently during dark period when active peaking around transitions. Solitary-housed did not vocalise whilst torpid remained torpor despite overlapping social-housing. Besides minor decrease USV isolated re-paired their siblings, changing contexts influence structure. In rare instances, temporally USVs occurred socially-housed grouped way could indicate coordination. observe broadband calls (BBCs) contemporaneous this paradigm, corroborating correlation physical aggression absent from our experiment. Overall, we find evidence suggest direct function hamster USVs. conclude understanding effects on behaviours, will inform experimental design future studies, especially where role interactions investigated.

Language: Английский

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Courtship vocalizations of wild house mice show highly dynamic changes and correlate with male copulatory success

Animal Behaviour, Journal Year: 2024, Volume and Issue: unknown, P. 123024 - 123024

Published: Dec. 1, 2024

Language: Английский

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What matters to a mouse? Effects of internal and external context on male vocal response to female squeaks

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract House mice adjust their signaling behavior depending on the social context of an interaction, but which aspects elicit strongest responses from these individuals is often difficult to determine. To explore how internal and external contextual factors influence house produce respond signals, we assessed dominant subordinate male differed in ultrasonic vocalization (USV) production response playback broadband vocalizations (BBVs, or squeaks) when given limited access a stimulus female. We used repeated measures design each was exposed two types trials with different odor conditions: either just female odors (Fem condition) addition potential competitors, other males (Fem+Male condition). The presence this assay served as proxy for “audience” interacted These conditions were replicated distinct cohorts individuals: familiar competitors Fem+Male condition (Familiar cohort), unfamiliar (Unfamiliar cohort). By assessing dominance status focal individual familiarity “audience”, are able may affect one another BBVs. Dominants subordinates did not differ baseline vocal (vocalizations produced prior squeak playback) squeaks. However, all groups, regardless condition, reduced BBV playback. prompted decrease level calling complexity repertoire compared that only included odor, effect also across status. Importantly, individual. findings suggest alter during courtship interactions cues indicate modulated by competitor cues.

Language: Английский

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Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 22, 2024

Variation in the mutual responsiveness of social partners to each other can be reflected behavioral suites that covary with neural activity ways track salience or valence interactions. Juvenile isolation alters behavior and during interaction, but whether how it covariation between has not been as well explored. To address this issue, four classes experimental subjects: isolated males, socially housed females, were paired an opposite-sex partner had housed. Social behaviors c-Fos expression serotonergic dorsal raphe nucleus (DRN) then measured subjects following Relative housing, postweaning led a decrease density neurons double-labeled for tryptophan hydroxylase dorsomedial subdivision DRN, regardless sex. Vocal non-vocal also affected by isolation. In interactions both ultrasonic vocalization (USVs) broadband vocalizations (squeaks) increased conjunction greater male investigation females. Neural measures correlated other. group, DRN was negatively USV production positively principal component corresponding defensive kicking females less mounting behavior. This correlation reversed direction males versus These findings confirm dynamics are activation suggest altered interaction parallel response female cues.

Language: Английский

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Computational Ethology: Short Review of Current Sensors and Artificial Intelligence Based Methods

Communications in computer and information science, Journal Year: 2023, Volume and Issue: unknown, P. 17 - 27

Published: Jan. 1, 2023

Language: Английский

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