Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

Vaccines, Journal Year: 2023, Volume and Issue: 11(4), P. 873 - 873

Published: April 20, 2023

The COVID-19 pandemic is a severe concern worldwide, particularly in Africa. Vaccines are crucial the fight against pandemic. This scoping review examined existing literature from 2020 to 2022 on individual, interpersonal, and structural barriers facilitators vaccination within Africa facilitate more informed health promotion interventions improve vaccine uptake. was conducted using Arksey O’Malley’s five-stage methodological framework. A comprehensive search undertaken 2021 six electronic databases: EBSCOhost, PubMed, Web of Science, ProQuest, WorldCat Discovery, Google Scholar. Data collected, charted into themes, summarized standard data extraction sheet Microsoft Excel. total forty (n = 40) published academic articles were reviewed, with many Nigeria 10), followed by Ethiopia 5) Ghana 4) rest elsewhere Thematic narratives used report themes: attitudes perceptions about vaccines, intention uptake vaccines; factors associated uptake; socio-demographic determinants affecting information sources for vaccines. ranged 25% 80.9%, resulting suboptimal rate (54.2%) African continent. Factors that promoted acceptance included confidence vaccines desire protect people. Age, education, gender most common significantly acceptance. Most studies revealed considerable exist Concerns potential side effects, ineffectiveness, perceived lack information, inaccessibility among unwillingness receive strongly correlated being female. Mass social media main regarding To encourage uptake, governments should pay attention refuting misinformation through integrated community-based approaches, such as creating messages convey than just information.

Language: Английский

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Lessons learned from COVID-19 vaccine acceptance among pregnant and lactating women from two districts in Kenya to inform demand generation efforts for future maternal RSV vaccines

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 27, 2024

Abstract Background Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infections globally, with most RSV-related deaths occurring in infants < 6 months age. The highest burden RSV low-and-middle income countries, and sub-Saharan Africa, may be responsible for almost half all hospital admissions severe or very pneumonia among under 1 year. There maternal vaccine on the horizon. Our study objective was to better understand how lessons learned from COVID-19 experience rollout pregnant lactating people Kenya could inform future rollout. Methods This qualitative interviewed 16 healthcare providers including doctors, nurses, midwives, community health workers, vaccinators. Participants were recruited two counties included that served diverse communities. A grounded theory approach used analyze data. Results As instrumental women Kenya, they provided Community sensitization emerged as critical lesson learned, communication, mobilization, education. Using communication ensure awareness RSV, harms benefits vaccines, providing up-to-date, clear information about vaccines lessons. Related participants identified need leaders gain trust communities, importance routinizing vaccine. Finally, education, outlined questions patients would have vaccine, those related safety concerns, duration protection, dosing. Conclusions one first studies has examined can an are directly involved rollout, their perspectives crucial successful acceptance.

Language: Английский

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COVID-19 Pharmacotherapy in Pregnancy: A Literature Review of Current Therapeutic Choices

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 787 - 787

Published: March 19, 2023

The clinical management of COVID-19 in pregnant women, who are considered a vulnerable population, remains uncertain even as the pandemic subsides. SARS-CoV-2 affects individuals multiple ways and has been associated with severe maternal morbidity mortality, well neonatal complications. unique anatomy physiology gestation make managing this population complex challenging task, emphasizing importance spreading knowledge expertise area. Therapeutic interventions require distinct consideration, taking into account differences pharmacokinetics, vertical transmission, drug toxicities, postnatal care. Currently, there is limited data on antiviral immunomodulating pharmacotherapy pregnancy. Some medication shown to be safe tolerated among women COVID-19; however, lack randomized trials studies patient evident. Available vaccines effective, no evidence harm fetus, embryo development, or short-term development. Pregnant should counseled about risks infection informed available protect themselves their families. Effective treatments for not withheld from individuals, more research needed ensure best outcomes.

Language: Английский

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Sociodemographic Factors Associated With Established and Novel Antenatal Vaccination Uptake in a Cohort of Pregnant Women in Uganda

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: 44(2S), P. S92 - S96

Published: Feb. 1, 2025

Introduction: Vaccination is a key strategy to safeguard the health of pregnant women and newborns. Although vaccine acceptance often higher in low- middle-income countries, COVID-19 pandemic has highlighted increasing hesitancy. Vaccine hesitancy, specifically women, must be understood increase uptake. We used data from Ugandan pregnancy registry study examine sociodemographic factors linked uptake vaccines (tetanus toxoid later COVID-19) pregnancy. Methods: Pregnant were recruited Kampala, Uganda, as part PREPARE (Prevention invasive Group B Streptococcus disease young infants: pathway for evaluation & licensure an investigational maternal GBS vaccine) September 1, 2020 until February 24, 2022. Demographic, socioeconomic obstetric collected alongside tetanus vaccination. Results: One thousand five hundred sixty-eight participants included: 151 (10%) unvaccinated, 11 (1%) received only, 1230 (78%) only 176 (11%) both. Lower vaccination rates seen attending fewer than 4 antenatal care episodes ( P < 0.001), those with parity = 0.036). Higher managerial or professional occupation education level, but paternal was not significantly associated Parish varied 0% 100%, 49 (29%) parishes showing rate <90%. Conclusions: This highlights route promotion, stark difference between new established vaccines. Further qualitative studies should investigate effective interventions establish safety benefit newer across all demographic groups.

Language: Английский

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COVID-19 vaccine acceptance and hesitancy in Cameroon: a systematic review and meta-analysis

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 17, 2025

The development of effective vaccines was a promising tool for ending the pandemic. However, success vaccination programme hinges on achieving substantial community acceptance. In Cameroon, numerous studies have investigated level acceptance, hesitancy, and perception COVID-19 vaccines, with mixed results. To provide comprehensive understanding these parameters, this meta-analysis aimed to estimate pooled proportion vaccine hesitancy in Cameroon. A systematic search online databases, including PubMed, Google Scholar, ScienceDirect, conducted identify relevant research articles. This study adhered Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. extracted data were compiled Microsoft Excel spreadsheet analyzed using R statistical software (version 4.3.3). calculated random-effects meta-analysis. Funnel plots, Egger's, Begg's tests used assess publication bias. Of 1,346 records identified through database search, 20 articles included review model showed that approximately 31.21% (95% CI: 23.49–38.94) participants willing accept vaccine. More than two-thirds population (68.49%; 95% 60.65–76.34) hesitant. Half (51.81%; 42.70-60.93), had negative acceptance rate progressed from first semester 2021 (27.21%; 10.38–44.05) 2022 (45.56%; 25.00-66.12). 29.29% 19.86–38.72) general 39.24% 22.84–55.64) healthcare workers. 70.39% 61.30–79.80) 57.42% 4.05–71.80) Although progress targeted interventions remain necessary address country. Strategies such as enhancing access accurate information, fostering trust institutions, strengthening engagement crucial increasing uptake.

Language: Английский

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COVID- 19 vaccine uptake and its determinants in Cameroon: a systematic review and meta-analysis (2021–2024)

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

COVID-19 vaccination is crucial for mitigating the pandemic's impact. However, vaccine hesitancy and access challenges have hindered global efforts. This meta-analysis aimed to estimate pooled uptake proportion identify associated determinants in Cameroon. review, conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines, identified articles through searches of electronic databases, including PubMed, ScienceDirect, Google Scholar, as well gray literature. The search encompassed published unpublished studies from 2021 2024 reporting on and/or acceptance Extracted data were compiled a Microsoft Excel spreadsheet analyzed using R statistical software (version 4.4.2). A random-effects model was employed when heterogeneity exceeded 50%. Publication bias assessed funnel plots, Egger's Begg's tests. Meta-regression used explore influence study characteristics. Twenty-two studies, encompassing 24,130 participants, included. 37.14% (95% CI: 29.24-45.05) with substantial (I2 = 98.2%, p < 0.001). Subgroup analyses revealed lower among general population (23.18%; 95% 10.11-36.25) community settings (16.0%; 0.97-31.04) compared healthcare workers (42.12%; 34.14-50.09). Younger age (OR 0.53; 0.42-0.67) inversely uptake, while being partnership 1.59; 1.11-2.27) positively associated. Higher levels education 1.75; 1.56-1.97), urban residence 1.66; 1.21-2.29) acceptance. suboptimal required ensure herd immunity. results this underline need step up efforts improve coverage, particularly most vulnerable populations. Identifying addressing factors underlying low coverage imperative if public health objectives are be met. Public interventions should tailored address specific concerns needs different groups marital statuses.

Language: Английский

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Vaccine inequity: a threat to Africa’s recovery from COVID-19

Tropical Medicine and Health, Journal Year: 2023, Volume and Issue: 51(1)

Published: Dec. 19, 2023

Abstract Background Vaccine inequity is a reality facing the Sub-Saharan Africa region as vaccine nationalism from high-income countries (HICs) leads to limited access lifesaving vaccines needed end pandemic. In Africa, significant portion of population has yet be vaccinated against Covid-19; however, barriers accessing such vaccines, including capacity challenges, still persist despite implementation COVAX facility meant support lower- and middle-income (LMICs) boost vaccination. Methods This study involved systemic narrative review where literature search was conducted using NCBI’s PMC BMC databases based on defined keywords. Three authors were in consensus applied settle disagreements validate findings. Results this systematic review, we report that remains challenge for LMICs HICs hoard even bypass procure doses directly manufacturers. Factors promote hesitancy include misinformation regarding Covid-19 vaccine, lack trust politicians pharmaceutical industry, concerns about safety efficacy. The policies implemented enhance coverage mandates, community engagement, partnerships, all seek equity vaccination ending Covid-19. Conclusion persists contributes prolonged pandemic LMICs. response, African governments have taken certain measures uptake but more needs done address resistance vaccines.

Language: Английский

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COVID-19 vaccine acceptance and predictors among pregnant women in Ethiopia: Systematic Review and Meta-Analysis

Public Health in Practice, Journal Year: 2023, Volume and Issue: 5, P. 100386 - 100386

Published: April 23, 2023

Despite safe and effective multiple vaccines, the COVID-19 pandemic continued to cause morbidity, mortality, healthcare burden. Pregnant women are among high-risk population for infection bad outcomes. Vaccination is one of most critical public health interventions halt devastating impact a pandemic. However, hesitancy, unwillingness, refusal take vaccines global challenges vaccination roll-out, especially in Africa, including Ethiopia. Country-specific evidence essential appropriate context-specific actions. Some single studies with inconsistent findings available Therefore, this meta-analysis aims determine pooled vaccine acceptance pregnant Systematic review study design was used synthesize overall predictors women. A search literature from PubMed, Scopus, Web Science, EMBASE, Cochrane Library, Google Scholar conducted until January 30, 2023. All that met eligibility criteria were screened, eight primary 4419 total subjects included meta-analysis. Two authors (DT MK) independently extracted all required data using standardized form. We analyzed STATA version 17 software. Heterogeneity checked Chocrane (Q-test) I2 tests. Finally, computed random-effect model. The revealed Ethiopia 42.46% (95%CI: 28.75–56.18). Further subgroup analysis stratified by region showed level Acceptance Amhara 35.16% (95% CI: 20.49–49.82), South Nation Nationality People 50.95% (95%C:12.24–89.67) Oromia 62.02% 58.27–65.76). Predictors awareness/knowledge (OR 3.33, 95%CI:2.13–4.14), maternal education 3.09, 95%CI: 1.67–4.51 chronic disease 2.81, 1.82–3.79. lowest reported region, while relatively highest observed region. found low emphasized significance improving awareness increase uptake. It crucial provide create about promote importance during antenatal care follow-up.

Language: Английский

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Determinants of COVID-19 Vaccination Decision-Making Behaviors among Pregnant Women in Sub-Saharan Africa: A Scoping Review

Vaccines, Journal Year: 2023, Volume and Issue: 11(7), P. 1233 - 1233

Published: July 12, 2023

Despite the availability of coronavirus disease 2019 (COVID-19) vaccination, uptake among pregnant women in Sub-Saharan Africa has been low. This scoping review aimed to identify and characterize determinants influencing COVID-19 vaccination decision-making behaviors Africa. We searched five online databases for articles on identified studies published English between March 2020 April 2023 that assessed vaccine-specific issues, psychosocial constructs, contextual factors associated with behaviors. Of fourteen identified, over half (57.1%) were cross-sectional; three used qualitative research methods; involved multi-country participants. Most acceptability willingness. Overall, 85.7% publications examined knowledge, attitudes, or both as critical vaccination. The prevalence vaccine during pregnancy was low (14.4–28%). While most current assess maternal would benefit from inclusion theory-informed driven measure additional constructs. Future should also employ study designs can determine causal pathways uptake.

Language: Английский

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Knowledge, Attitude, Acceptance, and Perceived Risks of COVID-19 Vaccines among Pregnant Women: Findings and Implications

SAS Journal of Medicine, Journal Year: 2024, Volume and Issue: 10(01), P. 9 - 19

Published: Jan. 2, 2024

Introduction: COVID-19 vaccines are essential in reducing symptoms and severity of the disease as well preventing infection with COVID-19. Vaccination pregnant women against has been recommended globally. In Zambia, there is a paucity information on knowledge, attitude, acceptance, perceived risks among women. Therefore, this study assessed vaccination attending antenatal care at Women Newborn Hospital (WNH) University Teaching Hospitals (UTHs) Lusaka, Zambia. Methods: This was descriptive cross-sectional conducted from August 2023 to October 300 Data were collected using structured questionnaire analysed Statistical Package for Social Science (SPSS) version 23.0. The Chi-square test used relationship between dependent independent variables. statistical significance 95% confidence level. Results: Of participants, 186 (62.0%) aged 24 34 years 185 (61.5%) aware that vaccine pregnancy. Overall, 284 (94.7%) had good 258 (86.0%) positive vaccinated. Additionally, 20 (17.5%) who not vaccinated willing be Furthermore, most participants felt safe use results show lower acceptance compared knowledge attitude levels. Having associated education status (X^2=33.011, p=0.001 level) (X^2=9.132, p=0.029 level). Conclusion: found WNH attitudes, perceptions, high ..........

Language: Английский

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