A pH-responsive bi-MIL-88B MOF coated with folic acid-conjugated chitosan as a promising nanocarrier for targeted drug delivery of 5-Fluorouracil

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 6, 2023

Cancer has remained one of the leading causes death worldwide, with a lack effective treatment. The intrinsic shortcomings conventional therapeutics regarding tumor specificity and non-specific toxicity prompt us to look for alternative mitigate these limitations. In this regard, we developed multifunctional bimetallic (FeCo) bi-MIL-88B-FC MOFs modified folic acid-conjugated chitosan (FC) as drug delivery systems (DDS) targeted 5-Fluorouracil (5-FU). bi-MIL-88B nanocarriers were characterized through various techniques, including powder X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray, thermogravimetric analysis, Fourier transform infrared spectroscopy. Interestingly, 5-FU@bi-MIL-88B-FC showed slower release 5-FU due gated effect phenomenon endowed by FC surface coating compared un-modified 5-FU@bi-MIL-88B. pH-responsive was observed, 58% loaded released in cancer cells mimicking pH (5.2) only 24.9% under physiological (5.4). vitro cytotoxicity cellular internalization experiments revealed superiority highly potent DDS against folate receptor (FR) positive SW480 cells. Moreover, presence Fe Co structure, exhibited peroxidase-like activity chemodynamic therapy. Based on results, could serve promising candidate smart sustained selective targeting.

Language: Английский

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Nanotechnology as a Promising Method in the Treatment of Skin Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2165 - 2165

Published: Feb. 10, 2024

The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, which nearly 350,000 melanoma, is often fatal. Treatment challenging and ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use nanoparticles may allow for early detection monitoring neoplastic changes determining effectiveness treatment. This article briefly reviews present understanding characteristics cancers, their epidemiology, risk factors. It also outlines possibilities using nanotechnology, especially nanoparticles, transport medicinal substances. Research over previous decade on carriers active substances indicates that drugs delivered more accurately tumor site, resulting higher therapeutic efficacy. describes application liposomes, carbon nanotubes, metal polymer existing therapies. discusses challenges encountered nanoparticle therapy improving performance. Undoubtedly, promising method help fight against cancer.

Language: Английский

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Burst Release from In Situ Forming PLGA-Based Implants: 12 Effectors and Ways of Correction

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 115 - 115

Published: Jan. 16, 2024

In modern pharmaceutical technology, modified-release dosage forms, such as in situ formed implants, are gaining rapidly popularity. These forms created based on a configurable matrix consisting of phase-sensitive polymers capable biodegradation, hydrophilic solvent, and the active substance suspended or dissolved it. The most used implants biocompatible biodegradable polymer, poly(DL-lactide-co-glycolide) (PLGA). Objective: This systematic review examines reasons for phenomenon ingredient “burst” release, which is major drawback PLGA-based likely ways to correct this improve quality with matrix. Data sources: Actual relevant publications PubMed Google Scholar databases were studied. Study selection: concept was theory developed during literature analysis 12 effectors burst release from forming PLGA. Only those studies that sufficiently fully disclosed one another component included. Results: resulted development approach called “12 Factor System”, considers various constant variable, endogenous exogenous factors can influence nature ‘burst release’ ingredients PLGA polymer-based implants. include porosity, polymer swelling, LA:GA ratio, end groups, molecular weight, structure, concentration, loading ingredients, combination, use co-solvents, addition excipients, change dissolution conditions. also considered different types kinetics possibility using “burst release” modify profile at site application form.

Language: Английский

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Multi-Stimuli-Responsive Tadpole-like Polymer/Lipid Janus Microrobots for Advanced Smart Material Applications

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(12), P. 15533 - 15547

Published: Feb. 15, 2024

Microrobots are of significant interest due to their smart transport capabilities, especially for precisely targeted delivery in dynamic environments (blood, cell membranes, tumor interstitial matrixes, blood–brain barrier, mucosa, and other body fluids). To perform a more complex micromanipulation biological applications, it is highly desirable microrobots be stimulated with multiple stimuli rather than single stimulus. Herein, the biodegradable biocompatible micromotors Janus architecture consisting PrecirolATO 5 polycaprolactone compartments inspired by anisotropic geometry tadpoles sperms newly designed. These bioinspired combine advantageous properties polypyrrole nanoparticles (NPs), high near-infrared light-absorbing agent photothermal conversion efficiency, magnetic NPs, which respond field exhibit multistimulus-responsive behavior. By combining both fields, we achieved an "on/off" propulsion mechanism that can enable us overcome tasks limitations liquid encountered actuation applications. Moreover, particles offer functions such as removing organic pollutants via Fenton reaction. Janus-structured motors provide broad perspective not only biosensing, optical detection, on-chip separation applications but also environmental water treatment catalytic activities micromotors.

Language: Английский

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Polyphyllin D-loaded solid lipid nanoparticles for breast cancer: Synthesis, characterization, in vitro, and in vivo studies

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 639, P. 122976 - 122976

Published: April 23, 2023

Language: Английский

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Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles

Gels, Journal Year: 2024, Volume and Issue: 10(5), P. 307 - 307

Published: May 1, 2024

Nanostructured lipid carriers (NLCs) have the potential to increase bioavailability and reduce side effects of docetaxel (DTX). However, only a small fraction nanoparticles given intravenously can reach solid tumor. In situ-forming gels combined with facilitate local administration promote drug retention at tumor site. Injectable hydrogels based on poloxamer 407 are excellent candidates for this hybrid nanoparticle-hydrogel system because their thermoresponsive behavior biocompatibility. Therefore, work aimed develop injectable containing NLCs intratumoral delivery DTX. To ensure sterility, obtained were autoclaved (121 °C 15 min) after preparation. Then, incorporation into impact steam sterilization nanocomposite evaluated concerning sol-gel transition, injectability, physicochemical stability. All formulations extruded through tested syringe-needle systems acceptable force (2.2-13.4 N) (49.5-317.7 N·mm) injection. Following sterilization, injection became easier in most cases, properties all remained practically unchanged according spectroscopical thermal analysis. The rheological evaluation revealed that liquid 25 underwent rapid gelation 37 °C. sterilized counterparts gelled 1-2 above body temperature, suggesting autoclaving conditions employed had rendered these unsuitable delivery.

Language: Английский

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Capturing the Dynamic Integrity of Carbocyanine Fluorophores-based Lipid Nanoparticles by the FRET technique

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanoparticles capable of dynamically reporting their structural integrity in real-time are a powerful tool to guide the design drug delivery technologies.

Language: Английский

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Preparation and Investigation of Janus Structured Micro/Nano Carriers: Release Kinetics of Multiple Drugs

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106631 - 106631

Published: Jan. 1, 2025

Language: Английский

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Evasion of P-gp mediated efflux and enhancement of bioavailability of protease inhibitor lopinavir by lipidic nanocarriers decorated with TPGS

Particulate Science And Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 14, 2025

Lopinavir (LPV) presents significant challenges in HIV management due to its poor permeability and low solubility. This study focuses on the formulation, optimization, characterization of nanostructured lipid carriers (NLC) enriched with TPGS enhance delivery bioavailability antiretroviral drugs (ARDs). LPV-NLC was developed using a modified solvent emulsification method optimized by employing quality-by-design (QbD) approach. The NLC formulation incorporated TPGS, achieving globule size 99.19 ± 4.68 nm, high entrapment efficiency 90.2 2.8%, polydispersity index (PDI) 0.236 0.025. Ex-vivo studies demonstrated 1.67-fold increase flux, highlighting superiority LPV-TPGS-NLC over LPV-S. Pharmacokinetic evaluation revealed 3.40-fold enhancement for LPV-TPGS-NLC, peak plasma concentration (Cmax) 1320.03 79.12 ng/mL, approximately twice that These findings underscore potential TPGS-enriched as novel drug platform improving oral therapeutic efficacy LPV. enhanced achieved this could enable dose reduction, thereby minimizing associated side effects patient compliance therapy.

Language: Английский

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Antibody-conjugated lipid nanoparticles as a targeted drug delivery system for hydrophobic drugs

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 97 - 136

Published: Jan. 1, 2025

Language: Английский

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