The neurology of anxiety—planning circuits DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 327 - 370

Published: May 7, 2024

Abstract ‘The neurology of anxiety—planning circuits’ extends the anxiolytic-derived neuropsychology survival circuits (including hippocampus and anterior cingulate cortex) to goal planning prefrontal cortex. It first discusses results from issues with early work using lesions as treatments neurotic disorders considers evolution frontal cortex in context defence hierarchy emphasizing fact that ‘deeper’ areas are phylogenetically more ancient. then details anatomy cortex, importance active memory dorsal ventral trend perception-action cycles, control conflict. also describes a ‘mesial’ linked internal insula source monitoring arousal/attention outputs Goal Inhibition System (GIS). The final sections integrate these data into new, extended, 2D theory systems.

Language: Английский

The Neuropsychology of Anxiety DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Language: Английский

Citations

73
Author response: Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats DOI Open Access
Eun Joo Kim, Mi-Seon Kong, Sanggeon Park

et al.

Published: Aug. 2, 2024

Pavlovian fear conditioning research suggests that the interaction between dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in formation of associative memories. However, their roles responding to naturalistic predatory threats, characterized by less explicit cues absence reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings rats during an 'approach food-avoid predator' task, focusing on responsiveness dPAG BLA neurons rapidly approaching robot predator. Optogenetic stimulation triggered fleeing behaviors increased activity naive rats. Notably, activated displayed immediate responses robot, demonstrating heightened synchronous compared did not respond stimulation. Additionally, use anterograde retrograde tracer injections into BLA, respectively, coupled with c-Fos activation response indicates midline thalamus may play intermediary role innate antipredatory defensive functioning.

Language: Английский

Citations

5
Inhibitory medial zona incerta pathway drives exploratory behavior by inhibiting glutamatergic cuneiform neurons DOI Creative Commons
Sandeep Sharma, Cecilia Badenhorst,

Donovan M. Ashby

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 7, 2024

Abstract The cuneiform nucleus (CnF) regulates locomotor activity, which is canonically viewed as being primarily involved in initiating locomotion and regulating speed. Recent research shows greater context dependency the functions of this nucleus. Glutamatergic neurons, contain vesicular glutamate transporter 2 (vGLUT2), regulate context-dependent speed CnF play a role defensive behavior. Here, we identify projections from medial zona incerta (mZI) to vGLUT2 neurons that promote exploratory Using fiber photometry recordings male mice, find mZI gamma-aminobutyric acid (GABA) increase activity during periods exploration. Activation GABAergic associated with reduced spiking neurons. Additionally, activating both retrogradely labeled mZI-CnF projection their terminals Inhibiting neuronal also increases These findings provide evidence for dynamic regulation circuit shaping

Language: Английский

Citations

4
Tonically active GABAergic neurons in the dorsal periaqueductal gray control instinctive escape in mice DOI Creative Commons
A. Vanessa Stempel, Dominic A. Evans, Oriol Pavón Arocas

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(13), P. 3031 - 3039.e7

Published: June 26, 2024

Escape behavior is a set of locomotor actions that move an animal away from threat. While these can be stereotyped, it advantageous for survival they are flexible.1Evans D.A. Stempel A.V. Vale R. Branco T. Cognitive control escape behaviour.Trends Cogn. Sci. 2019; 23: 334-348Abstract Full Text PDF PubMed Scopus (84) Google Scholar,2Edwards D.H. Heitler W.J. Krasne F.B. Fifty years command neuron: The neurobiology in the crayfish.Trends Neurosci. 1999; 22: 153-161Abstract (260) Scholar,3Peek M.Y. Card G.M. Comparative approaches to escape.Curr. Opin. Neurobiol. 2016; 41: 167-173Crossref (49) Scholar For example, probability depends on predation risk and competing motivations,4Lima S.L. Dill L.M. Behavioral decisions made under predation: review prospectus.Can. J. Zool. 1990; 68: 619-640Crossref Scholar,5Collier A. Hodgson J.Y. A shift strategy by grasshopper prey response repeated pursuit.Southeastern Nat. 2017; 16: 503-515Crossref (3) Scholar,6Cooper W.E. Frederick W.G. Optimal flight initiation distance.J. Theor. Biol. 2007; 244: 59-67Crossref (318) Scholar,7Edut S. Eilam D. Rodents open space adjust their behavioral different levels during barn-owl attack.BMC Ecol. 2003; 3: 10Crossref (42) Scholar,8Filosa Barker A.J. Dal Maschio M. Baier H. Feeding state modulates choice processing stimuli zebrafish tectum.Neuron. 90: 596-608Abstract Scholar,9Azevedo E.P. Tan B. Pomeranz L.E. Ivan V. Fetcho Schneeberger Doerig K.R. Liston C. Friedman J.M. Stern S.A. limbic circuit selectively links active food suppression.eLife. 2020; 9e58894Crossref Scholar,10de Araujo Salgado I. Li Burnett C.J. Rodriguez Gonzalez Becker J.J. Horvath Earnest Kravitz Krashes M.J. Toggling between food-seeking self-preservation behaviors via hypothalamic networks.Neuron. 2023; 111: 2899-2917.e6Abstract (6) Scholar,11Cooper W.E.J. Blumstein D.T. Escaping Predators: An Integrative View Decisions. Cambridge University Press, 2015Crossref safety requires continuous adjustments trajectory must terminate at appropriate place time.12Blank goitered gazelle.Behav. Processes. 2018; 147: 38-47Crossref (8) Scholar,13Claudi F. Campagner Innate heuristics fast learning support route selection mice.Curr. 2022; 32: 2980--2987.e5Abstract (0) Scholar,14Domenici P. Blagburn Bacon J.P. Animal escapology I: theoretical issues emerging trends trajectories.J. Exp. 2011; 214: 2463-2473Crossref (141) Scholar,15Eilam Die hard: blend freezing fleeing as dynamic defense - Implications defensive behavior.Neurosci. Biobehav. Rev. 2005; 29: 1181-1191Crossref (177) Scholar,16Shamash Olesen S.F. Iordanidou Banerjee N. Mice learn multi-step routes memorizing subgoal locations.Nat. 2021; 24: 1270-1279Crossref (15) This degree flexibility suggests modulatory components, like inhibitory networks, act neural circuits controlling instinctive escape.17Lefler Y. role periaqueductal gray behavior.Curr. 60: 115-121Crossref (44) Scholar,18Depaulis Bandler Midbrain Periaqueductal Gray Matter: Functional, Anatomical, Neurochemical Organization. Springer, 1991Crossref Scholar,19Shaikh M.B. Siegel GABA-mediated regulation feline aggression elicited midbrain gray.Brain Res. 507: 51-56Crossref Scholar,20Behbehani M.M. Jiang Chandler S.D. Ennis effect GABA its antagonists neurons rat.Pain. 40: 195-204Abstract (105) Scholar,21Silva B.A. Gross C.T. Gräff innate fear: detection, integration, action, memorization.Learn. Mem. 544-555Crossref (104) Scholar,22Fratzl Koltchev A.M. Vissers Y.L. Marques-Smith Hofer S.B. Flexible visually evoked ventral lateral geniculate nucleus.Neuron. 109: 3810-3822.e9Abstract In mice, decision imminent threats implemented feedforward midbrain, where excitatory vesicular glutamate transporter 2-positive (VGluT2+) dorsal (dPAG) compute vigor.23Tovote Esposito M.S. Botta Chaudun Fadok Markovic Wolff S.B.E. Ramakrishnan Fenno L. Deisseroth K. et al.Midbrain behaviour.Nature. 534: 206-212Crossref (452) Scholar,24Evans Ruehle Lefler synaptic threshold mechanism computing decisions.Nature. 558: 590-594Crossref (256) Scholar,25Deng Xiao X. Wang Z. neuronal activities underlie aspects behaviors.J. 36: 7580-7588Crossref (125) Here we tested hypothesis local GABAergic within dPAG setting excitability network. Using vitro patch-clamp vivo activity recordings, found transporter-positive (VGAT+) fire action potentials tonically absence inputs major source inhibition VGluT2+ neurons. Activity VGAT+ cells transiently decreases onset increases escape, peaking termination. Optogenetically increasing or decreasing changes when stimulation delivered threat duration after initiation. We conclude firing sets controls execution action.

Language: Английский

Citations

4
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease DOI
Juan Wang, Xiaoting Wang, Hui Li

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102097 - 102097

Published: Oct. 28, 2023

Language: Английский

Citations

7
Anxiety and personality DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 371 - 430

Published: May 7, 2024

Abstract ‘Anxiety and personality’ links the anxiolytic-derived state neuropsychology of previous chapters to personality traits. Traits are seen as sensitivities structures, goal control systems, more global modulators systems. It lays ground work for seeing psychiatric disorders resulting from one or extreme sensitivities. While main focus is anxiety, it also discusses implications Reinforcement Sensitivity Theory (RST) with additional comment on Big 5. reviews issues arising word meanings, evolution, need biomarkers, hierarchical organization, continuity versus discontinuity provides recommendation application work, throughout. distinguishes neuroticism trait a new dopaminergic neurology reinforcement sensitivity, strongly reinforcers, first anxiety disorder biomarker, identifies problems existing RST scales, future neural solutions.

Language: Английский

Citations

2
Central stress pathways in the development of cardiovascular disease DOI
Joe Braun, Mariya Patel, Tatiana Kameneva

et al.

Clinical Autonomic Research, Journal Year: 2023, Volume and Issue: 34(1), P. 99 - 116

Published: Dec. 17, 2023

Language: Английский

Citations

5
A conserved brainstem region for instinctive behaviour control: The vertebrate periaqueductal gray DOI Creative Commons
A. Vanessa Stempel

Current Opinion in Neurobiology, Journal Year: 2024, Volume and Issue: 86, P. 102878 - 102878

Published: April 24, 2024

Instinctive behaviours have evolved across animal phyla and ensure the survival of both individual species. They include that achieve defence, feeding, aggression, sexual reproduction, or parental care. Within vertebrate subphylum, brain circuits support instinctive behaviour output are evolutionarily conserved, being present in oldest group living vertebrates, lamprey. Here, I will provide an evolutionary comparative perspective on function a conserved brainstem region central to initiation execution virtually all behaviours-the periaqueductal gray. In particular, focus recent advances neural mechanisms gray underlie production different within

Language: Английский

Citations

1
Fundamentals of the septo-hippocampal system DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 241 - 284

Published: May 7, 2024

Abstract ‘Fundamentals of the septo-hippocampal system’ derives a range data principles from an overview sept-hippocampal data. It reviews anxiolytic action on system and behaviour; control rhythmical slow activity (RSA)/‘theta’ activity; relationship to sensory processing, working/active memory, conditioning, emotion. then discusses how approach understanding system, its anatomy, role in long-term memory via mismatch detection. emphasizes important affectively linked neuromodulatory systems hippocampal function; hippocampus at least 70 chemical factors, including corticosterone/cortisol. Its series are solidly based available so all theories should be judged against them. While place severe limits assumptions machinery theory, they not sufficient provide theory themselves.

Language: Английский

Citations

1
Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats DOI Creative Commons
Eun Joo Kim, Mi-Seon Kong, Sanggeon Park

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 5, 2023

Pavlovian fear conditioning research suggests that the interaction between dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in formation of associative memories. However, their roles responding to naturalistic predatory threats, characterized by less explicit cues absence reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings rats during an 'approach food-avoid predator' task, focusing on responsiveness dPAG BLA neurons rapidly approaching robot predator. Optogenetic stimulation triggered fleeing behaviors increased activity naive rats. Notably, activated displayed immediate responses robot, demonstrating heightened synchronous compared did not respond stimulation. Additionally, use anterograde retrograde tracer injections into BLA, respectively, coupled with c-Fos activation response indicates midline thalamus may play intermediary role innate antipredatory-defensive functioning.

Language: Английский

Citations

3