Comparison of DL-Methionine and L-Methionine levels in liver metabolism activity in commercial broilers fed a diet without antibiotic growth promoters

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 598 - 605

Published: March 1, 2025

Background and Aim: Methionine is an essential amino acid in broiler nutrition, playing a crucial role growth performance liver metabolism. As alternative to antibiotic promoters (AGPs), this study aimed evaluate the effects of DL-Methionine L-Methionine supplementation on metabolism, antioxidant activity, broilers raised without AGPs. Materials Methods: A total 440 one-day-old Cobb 500 male chicks were assigned 11 groups: control group 10 treatment groups receiving graded levels (70%, 85%, 100%, 115%, 130%) either or L-Methionine. The assessed body weight, mass index, D-amino oxidase (DAAO) serum glutathione concentration, histopathology across three stages: Starter (day 11), grower 25), finisher 35). Results: resulted greater weight gain compared DL-Methionine, particularly stage. demonstrated stronger influence metabolism by increasing DAAO activity reducing oxidative stress, as indicated lower levels. No significant histopathological alterations observed among groups, confirming safety both methionine sources. Conclusion: While improved performance, effectively enhanced reduced stress. These findings suggest that may support function, whereas more effective for Keywords: chickens,

Language: Английский

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Linking gastrointestinal tract structure, function, and gene expression signatures to growth variability in broilers: a novel interpretation for flock uniformity

Poultry Science, Journal Year: 2024, Volume and Issue: 103(10), P. 104158 - 104158

Published: Aug. 2, 2024

Variation in body weight (BW) within broiler flocks is a significant challenge poultry production. Investigating differences gut-related parameters between low (LBW) and high BW (HBW) chicks may provide insights into the underlying causes of heterogeneity. 908 day-old male were reared until d 7 then ranked LBW HBW groups. Thereafter, performance compared groups periodically. On 7, 14, 38, visceral organ characteristics, intestinal permeability, duodenal ileal histomorphology examined. Expression profiles analyzed for 79 genes related to gut barrier function, immune nutrient transport, hormones, receptors, metabolism, oxidation using high-throughput qPCR. Student's t-tests performed compare measurements. Multivariate statistics, including partial least square regression (PLSR) analysis, applied identify combinations key discriminating groups, offering predictive capability phenotypic variations. The group remained heavier at each timepoint, which could be explained by higher feed intake. had shorter relative small intestine length but villus height villi height/crypt depth ratios. demonstrated increased permeability on 38. showed upregulation response TNF-α CYP450 while AHSA1 HSPA4 expressions 7. metabolism mTOR EIF4EBP1 satiety-induced hormone cholecystokinin tended increase expression hunger ghrelin Genes categories consistently upregulated group. PLSR models revealed 4, 12, 11 sets highly phenotypes respectively. These findings suggest that growth rates are linked size, structure, function chickens, mechanisms regulating BW.

Language: Английский

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Breast myopathy co-occurrence and its impact on carcass and meat quality attributes in broiler chickens

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104625 - 104625

Published: Dec. 3, 2024

Wooden breast (WB), spaghetti meat (SM) and white striping (WS) are significant research focuses due to their impact on quality. This study examines the relationship between different myopathies in chickens from a commercial slaughterhouse compares physicochemical traits breasts with single multiple control (CO-no apparent myopathy). A total of 240 were evaluated for myopathy presence, severity location, parameters (i.e. carcass weight color; color, pH, electrical conductivity, drip, thaw cooking loss, Warner-Brazler texture, moisture, protein, fat collagen content). 54.8 % affected presented myopathies, within them, correlation WB WS was found (Kendall's tau = 0.24; P < 0.01). Additionally, more prevalent cranial region (P 0.05). Most varied significantly across classes. Breasts presenting WB, alone or combination, most altered, showing: heavier carcasses higher yield redder yellower skin; L*, b* Hue, lower protein content, loss resistance shear SM, combination often had intermediate values CO breasts, few exceptions color content. The principal component discriminant analysis revealed proximity WS, combinations, clear separation WB-SM. Breast yield, content discriminative categories. partial least squares could not differentiate single, (accuracy 42.6 %), but showed 80.63 balanced accuracy WB-SM, 74.26 SM 74.61 CO. These findings confirm previously reported data quality, provide thorough that can help industries improve postmortem classification identification.

Language: Английский

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Effects of the Addition of Trichoderma reesei Cellulase to Broiler Chicken Diets for a 21-Day Period

Animals, Journal Year: 2024, Volume and Issue: 14(10), P. 1467 - 1467

Published: May 15, 2024

The cellulose present in the cell wall of vegetables prevents greater release nutrients to animal. Therefore, use cellulase enzyme is a viable strategy as it capable breaking bonds, releasing such glucose, increasing dietary energy, and thus improving productive performance birds. Trichoderma reesei efficient production cellulase, which produced via submerged fermentation followed by purification, formulation, drying. an experiment was carried out using 240 male broilers Cobb-500® lineage verify effects resulting from addition powdered (500 g/t 1000 g/t) liquid mL/t) over period 1 21 days. A completely randomized experimental design used, consisting four treatments with six replications ten birds per replication that were housed cage. It observed digestibility results significantly different supplementation. Also, relative weight large intestine between one seven days increased when added at g/t. In eight 14 life, consumed only basal diet obtained higher levels liver protein than those received enzyme. However, 15 days, feed effect did not occur thus, conclusive whether hepatotoxicity occurs cellulase. For blood parameters, diets regarding electrolytes. concluded this can be included animals’ diet.

Language: Английский

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Interpretation of Chinese expert consensus on the whole-course management of hepatocellular carcinoma (2023 edition)

Hepatoma Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Language: Английский

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Occurrence of Hyperhomocysteinemia in Broilers and Reduction of Its Harmful Effects with Betaine- and Berberine-Supplemented Diets

Veterinary medicine and science, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Homocysteine is a metabolic intermediate in the methionine-cysteine conversion. High level of homocysteine blood leads to changes methylation pathways and consequently transcriptional activation; therefore, it can disrupt gene expression. This chapter presents biochemical transformation broilers demonstrates beneficial effects certain bioactive feed additives (betaine berberine) health-related production problems caused by accumulation homocysteine. Based on recent scientific findings, following conclusions have been drawn: Hyperhomocysteinosis has received little attention field avian physiology research. Currently used additives, such as betaine, potentially decrease circulating homocysteine, but support only one responsible for decomposition. Various phytonutrients may be suitable owing their pleiotropic components, berberine. It maintain redox homeostasis animals modulate immune responses therefore able provide liver protective functions. Additionally, encourage healthy tissue express enzymes that are degradation Further studies recommended investigate how effectively berberine reduce incidence hyperhomocysteinemia whether necessary use supplements throughout life cycles birds.

Language: Английский

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