The Spleen Virome of Australia’s Endemic Platypus Is Dominated by Highly Diverse Papillomaviruses DOI Creative Commons
Subir Sarker, Saranika Talukder, Ajani Athukorala

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 176 - 176

Published: Jan. 26, 2025

The platypus (Ornithorhynchus anatinus), a unique monotreme, represents pivotal point in mammalian evolution with its distinctive traits, such as electroreception and venom production. Despite evolutionary significance, the viral diversity within platypuses remains poorly understood. This study employed next-generation sequencing to investigate virome of dead platypuses, uncovering range novel divergent viruses. Among identified viruses were four complete genomes papillomaviruses (OaPV1–4) exhibiting substantial divergence from known strains, suggesting genus subfamily Secondpapillomavirinae. Additionally, five parvoviruses detected, including two genomes, highlighting complex ecosystem platypus. Phylogenetic analysis placed these branches, further demonstrating platypus’s significance. A circular DNA virus, tombus-like nodamuvirus also identified, expanding understanding monotremes. These findings offer crucial insights into one most lineages, emphasising need for exploration assess ecological pathological impacts on populations.

Language: Английский

Host and viral traits predict zoonotic spillover from mammals DOI Creative Commons
Kevin J. Olival,

Parviez R. Hosseini,

Carlos Zambrana‐Torrelio

et al.

Nature, Journal Year: 2017, Volume and Issue: 546(7660), P. 646 - 650

Published: June 20, 2017

Analysis of a comprehensive database mammalian host–virus relationships reveals that both the total number viruses infect given species and proportion likely to be zoonotic are predictable this enables identification geographic locations where novel zoonoses found. Zoonotic viruses, many originating in wild mammals, pose serious threat global public health. Peter Daszak colleagues create relationships, which they analyse determine patterns virus distribution mammals. They identify various factors influence diversity as well predict per species. In doing so, The majority human emerging infectious diseases zoonotic, with originate mammals particular concern (for example, HIV, Ebola SARS)1,2,3. Understanding viral wildlife determinants successful cross-species transmission, or spillover, therefore key goals for pandemic surveillance programs4. However, few analytical tools exist host harbour next virus, can cross boundaries5,6,7. Here we conduct analysis show predictable. After controlling research effort, is predicted by phylogenetic relatedness humans, taxonomy population within range—which may reflect human–wildlife contact. We demonstrate bats significantly higher than all other orders. also taxa regions largest estimated 'missing viruses' zoonoses' highest value future surveillance. then breadth traits significant predictors potential, providing framework assess if newly discovered could people.

Language: Английский

Citations

1027

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014 DOI Creative Commons
Marianne Besnard,

Stéphane Lastère,

Anita Teissier

et al.

Eurosurveillance, Journal Year: 2014, Volume and Issue: 19(13)

Published: April 3, 2014

Binary file ES_Abstracts_Final_ECDC.txt matches

Language: Английский

Citations

783

The spread and evolution of rabies virus: conquering new frontiers DOI
Christine R. Fisher, Daniel G. Streicker, Matthias J. Schnell

et al.

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 16(4), P. 241 - 255

Published: Feb. 26, 2018

Language: Английский

Citations

287

Bacterial defences: mechanisms, evolution and antimicrobial resistance DOI
William P. J. Smith, Benjamin R. Wucher, Carey D. Nadell

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(8), P. 519 - 534

Published: April 24, 2023

Language: Английский

Citations

181

The Ecology and Evolution of Influenza Viruses DOI Open Access
Michelle Wille, Edward C. Holmes

Cold Spring Harbor Perspectives in Medicine, Journal Year: 2019, Volume and Issue: 10(7), P. a038489 - a038489

Published: Dec. 23, 2019

The patterns and processes of influenza virus evolution are fundamental importance, underpinning such traits as the propensity to emerge in new host species ability rapidly generate antigenic variation. Herein, we review key aspects ecology viruses. We begin with an exploration origins viruses within orthomyxoviruses, showing how our perception evolutionary history these has been transformed metagenomic sequencing. then outline diversity subtypes different by which have emerged hosts, a particular focus on role played segment reassortment. turn attention documenting spread phylodynamics seasonal A B human populations, including drivers evolution, finish discussion at scale individual hosts.

Language: Английский

Citations

152

Host Specificity and Geographic Dispersion Shape Virome Diversity in Rhinolophus Bats DOI Open Access
Daxi Wang,

Linmiao Li,

Z. Y. Ren

et al.

Molecular Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

ABSTRACT Rhinolophus bats have been identified as natural reservoirs for viruses with global health implications, including severe acute respiratory syndrome–related coronaviruses (SARSr‐CoV) and swine diarrhoea syndrome‐related coronavirus (SADSr‐CoV). In this study, we characterised the individual viromes of 603 to systematically investigate diversity, abundance geographic distribution viral communities within R. affinis , sinicus 11 other bat species. The massive metatranscriptomic data revealed substantial genome resources 133 vertebrate‐infecting clusters, which contain occasional cross‐species transmission across mammalian orders especially families. Notably, those included nine clusters closely related human and/or livestock pathogens, such SARS‐CoVs SADS‐CoVs. investigation also highlighted distinct features diversity between colonies, appear be influenced by host population genetics comparison SARSr‐CoVs further showed varied impact specificity along genome‐wide diversification modular evolution among Overall, findings point a complex interaction genetic way spread structure populations, calling continued surveillance efforts understand factors driving emergence in populations. These results present underestimated spillover risk viruses, highlighting importance enhancing preparedness emerging zoonotic viruses.

Language: Английский

Citations

3

Heritable symbionts in a world of varying temperature DOI Open Access
Chris Corbin,

Eleanor Heyworth,

Julia Ferrari

et al.

Heredity, Journal Year: 2016, Volume and Issue: 118(1), P. 10 - 20

Published: Oct. 5, 2016

Language: Английский

Citations

167

Opportunities and challenges in modeling emerging infectious diseases DOI Open Access
C. Jessica E. Metcalf, Justin Lessler

Science, Journal Year: 2017, Volume and Issue: 357(6347), P. 149 - 152

Published: July 14, 2017

The term “pathogen emergence” encompasses everything from previously unidentified viruses entering the human population to established pathogens invading new populations and evolution of drug resistance. Mathematical models emergent allow forecasts case numbers, investigation transmission mechanisms, evaluation control options. Yet, there are numerous limitations pitfalls their use, often driven by data scarcity. Growing availability on pathogen genetics ecology, coupled with computational methodological innovations, is amplifying power inform public health response emergence events. Tighter integration infectious disease practice development resources at ready has potential increase timeliness quality responses.

Language: Английский

Citations

151

Horizontal acquisition of transposable elements and viral sequences: patterns and consequences DOI Creative Commons
Clément Gilbert, Cédric Feschotte

Current Opinion in Genetics & Development, Journal Year: 2018, Volume and Issue: 49, P. 15 - 24

Published: March 2, 2018

Language: Английский

Citations

140

The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts DOI Creative Commons
Ben Longdon, Jarrod D. Hadfield, Jonathan P. Day

et al.

PLoS Pathogens, Journal Year: 2015, Volume and Issue: 11(3), P. e1004728 - e1004728

Published: March 16, 2015

Emerging infectious diseases are often the result of a host shift, where pathogen originates from different species. Virulence--the harm does to its host-can be extremely high following shift (for example Ebola, HIV, and SARs), while other shifts may go undetected as they cause few symptoms in new host. Here we examine how virulence varies across species by carrying out large cross infection experiment using 48 Drosophilidae an RNA virus. Host resulted dramatic variation virulence, with benign infections some rapid death others. The change was highly predictable phylogeny, hosts clustering together distinct clades displaying or low virulence. High levels associated viral loads, this determine transmission rate

Language: Английский

Citations

139