Molecular Insights into Innate Immune Response in Captive Koala Peripheral Blood Mononuclear Cells Co-Infected with Multiple Koala Retrovirus Subtypes DOI Creative Commons
Mohammad Enamul Hoque Kayesh, Md Abul Hashem,

Fumie Maetani

et al.

Pathogens, Journal Year: 2022, Volume and Issue: 11(8), P. 911 - 911

Published: Aug. 14, 2022

Koala retrovirus (KoRV) exists in both endogenous and exogenous forms has appeared as a major threat to koala health conservation. Currently, there are twelve identified KoRV subtypes: an subtype (KoRV-A) eleven subtypes (KoRV-B -I, KoRV-K, -L, -M). However, information about subtype-related immune responses koalas against multiple infections is limited. In this study, we investigated KoRV-subtype (A, B, C, D, F)-related immunophenotypic changes, including CD4, CD8b, IFN-γ, IL-6, IL-10 mRNA expression, peripheral blood mononuclear cells (PBMCs) obtained from captive (n = 37) infected with (KoRV-A F) reared seven Japanese zoos. Based on infection profiles, no significant difference CD4 CD8b expression was observed the study populations. different infections, found that IFN-γ PMBCs differs insignificantly (p 0.0534). addition, IL-6 also did not vary significantly PBMCs based differences. We Toll-like receptors (TLRs) response, TLR2-10, TLR13 subtypes. Significant differential of TLR5, 7, 9, 10, 13 Therefore, findings it assumed co-infection might modify host innate TLRs responses. have more clear understanding regarding effect cytokines TLR response pathogenesis, further large-scale studies negative for other -L -M) required.

Language: Английский

None DOI Open Access
Damien P. Higgins, David E. Alquezar‐Planas,

David Alquezar

et al.

Technical Reports of the Australian Museum online, Journal Year: 2023, Volume and Issue: 38

Published: June 20, 2023

This issue of Technical Reports the Australian Museum Online number 38 (2023) has twelve peer-reviewed papers, edited by David E. Alquezar-Planas, Damien P. Higgins, Cora L. Singleton, and Alex D. Greenwood, a discussion summary, from Second Koala Retrovirus Workshop held online, 25–27 May 2021. The First was in San Diego 2013 with series papers published 24 (2014). Biology veterinary specialists together assessed discussed then state knowledge koala retrovirus (KoRV) formed professional bridges networks. Much progress been made years since due to expanding international collaborations. COVID-19 forced online. Again 2021, presenters were invited write short based on their presentations, resulting present articles. Additionally, discussions workshop presentations highlighted current knowledge, information gaps, recommendations for ways move forwards, all summarized this volume.

Language: Английский

Citations

0
Preface to the Second Koala Retrovirus Workshop online 25–27 May 2021. In Proceedings of the Second Koala Retrovirus Workshop, ed. D. E. Alquezar-Planas, D. P. Higgins, C. L. Singleton, and A. D. Greenwood DOI Open Access
David E. Alquezar‐Planas, Damien P. Higgins, Cora L. Singleton

et al.

Technical Reports of the Australian Museum online, Journal Year: 2023, Volume and Issue: 38, P. 1 - 2

Published: June 20, 2023

In 2013, the first Koala Retrovirus Workshop was held in San Diego, bringing together biology and veterinary specialists to assess discuss state of knowledge on koala retrovirus (KoRV) form professional bridges networks. Tremendous progress has been made years following Diego meeting, large part due ongoing international collaborations that were fostered study KoRV. This volume presents peer-reviewed papers from most oral presentations discussions during Second 2021. Unfortunately, COVID-19 pandemic forced workshop into an online only format. Despite this limitation, three days based highlighted current important information gaps, culminating suggested ways forward, all summarized volume.

Language: Английский

Citations

0
Molecular Insights into Innate Immune Response in Captive Koala Peripheral Blood Mononuclear Cells Co-Infected with Multiple Koala Retrovirus Subtypes DOI Creative Commons
Mohammad Enamul Hoque Kayesh, Md Abul Hashem,

Fumie Maetani

et al.

Pathogens, Journal Year: 2022, Volume and Issue: 11(8), P. 911 - 911

Published: Aug. 14, 2022

Koala retrovirus (KoRV) exists in both endogenous and exogenous forms has appeared as a major threat to koala health conservation. Currently, there are twelve identified KoRV subtypes: an subtype (KoRV-A) eleven subtypes (KoRV-B -I, KoRV-K, -L, -M). However, information about subtype-related immune responses koalas against multiple infections is limited. In this study, we investigated KoRV-subtype (A, B, C, D, F)-related immunophenotypic changes, including CD4, CD8b, IFN-γ, IL-6, IL-10 mRNA expression, peripheral blood mononuclear cells (PBMCs) obtained from captive (n = 37) infected with (KoRV-A F) reared seven Japanese zoos. Based on infection profiles, no significant difference CD4 CD8b expression was observed the study populations. different infections, found that IFN-γ PMBCs differs insignificantly (p 0.0534). addition, IL-6 also did not vary significantly PBMCs based differences. We Toll-like receptors (TLRs) response, TLR2-10, TLR13 subtypes. Significant differential of TLR5, 7, 9, 10, 13 Therefore, findings it assumed co-infection might modify host innate TLRs responses. have more clear understanding regarding effect cytokines TLR response pathogenesis, further large-scale studies negative for other -L -M) required.

Language: Английский

Citations

0