Biological characteristics of a new long-chain fatty acid transport protein 1 from Trichinella spiralis and its participation in lipid metabolism, larval moulting, and development DOI Creative Commons

Yang Li Li,

Qi Lu,

Wen Wen Zheng

et al.

Veterinary Research, Journal Year: 2024, Volume and Issue: 55(1)

Published: Sept. 30, 2024

Language: Английский

Modulation of the rat intestinal microbiota in the course of Anisakis pegreffii infection DOI Creative Commons

Minhao Zeng,

Shan Li, Qingbo Lv

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: May 9, 2024

are globally distributed, marine parasitic nematodes that can cause human health problems, including symptoms such as vomiting, acute diarrhea, and allergic reactions. As primarily affect the patient's digestive tract, intestinal helminths interact directly with host microbiota through physical contact, chemicals, or nutrient competition. It is widely accepted plays a crucial role in regulation of immunity.

Language: Английский

Citations

1
ACV with/without IVM: a new talk on intestinal CDX2 and muscular CD34 and Cyclin D1 during Trichinella spiralis infection DOI Creative Commons
Enas A. El Saftawy, Basma Emad Aboulhoda,

Faraz Hassan

et al.

Helminthologia, Journal Year: 2024, Volume and Issue: 61(2), P. 124 - 141

Published: June 1, 2024

Summary The current study assessed the efficacy of Acyclovir (ACV) and Ivermectin (IVM) as monotherapies combined treatments for intestinal muscular stages Trichinella spiralis infection. One-hundred Swiss albino mice received orally 250 ± 50 infectious larvae were divided into infected-untreated (Group-1), IVM-treated (Group-2), ACV-treated (Group-3), IVM+ACV (Group-4), healthy controls (Group-5). Each group was subdivided subgroup-A-enteric phase (10 mice, sacrificed day-7 p.i.) subgroup-B-muscular day-35 p.i.). Survival rate body weight recorded. Parasite burden histopathology assessed. In addition, immunohistochemical expression epithelial CDX2 in CyclinD1 well CD34 evaluated. Compared, IVM ACV showed insignificant differences amelioration enteric histopathology, except lymphocytic counts. muscle phase, variable disruptions encapsulated larvae. Compared with monotherapies, treatment performed relatively better improvement inflammation reduction parasite burden. positively correlated burden, while a negative correlation. CyclinD1. negatively +ACV significantly ameliorated CDX2, CyclinD1, expressions compared monotherapies. Conclusion. T. infection-associated induced expressions, whereas reduced. molecular tumorigenic effect nematode remains questionable. Nevertheless, appeared to be promising anthelminthic anti-inflammatory combination that, parallel, rectified expressions.

Language: Английский

Citations

1
The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis DOI Creative Commons
Hualei Sun, S. Long, Miao Jiang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Abstract Inflammatory bowel disease (IBD) increases the risk of colorectal cancer, and it has potential to diminish quality life. Clinical experimental evidence demonstrate protective aspects parasitic helminth infection against IBD. However, studies on inhibition inflammation by have overlooked a key determinant health: gut microbiota. Infection with helminths induces alterations in host microbiota composition. influence mechanism infections induced changes development IBD not yet been elucidated. In this study, we analyzed intersection Trichinella spiralis bacteria regulation colitis related mechanisms. T. infected mice were treated antibiotics or cohused wild type mice, then challenged DSS-colitis severity, immune responses goblet cells assessed. Gut composition was assessed 16 s rRNA sequencing SCFAs measured. Results showed that protection abrogated antibiotic treatment, cohousing - suppressed mice. Bacterial community profiling revealed an increase abundance bacterial genus Muribaculum unclassified_Muribaculaceae cohoused Metabolomic analysis demonstrated increased propionic acid feces from Data also microbiome modulated exhibited enhanced cell differentiation elevated IL-10 levels Taken together, these findings identify as critical component anti-colitic effect gives beneficial insights into processes which alleviates colitis. Author Summary encompasses Crohn’s Disease Ulcerative Colitis. It affects both children adults. Reports highlighted use their byproducts possible treatment for Accumulating suggests is factor modulating prior DSS-induced Specifically, reshaped resulting SCFA-producing thereby producing larger amount acid. Furthermore, levels, ultimately ameliorating These suggest modulation during plays crucial role suppression colitis, any intention-to-treat therapy should be based patient’s immunological microbiological response helminth.

Language: Английский

Citations

0
Trichinella spiralis alleviates LPS-induced acute lung injury by modulating the protective Th2 immune response DOI

Ruohang Sun,

Jing Ding, Yaming Yang

et al.

Veterinary Parasitology, Journal Year: 2024, Volume and Issue: 333, P. 110206 - 110206

Published: May 24, 2024

Language: Английский

Citations

0
PD-1 deficiency impairs eosinophil recruitment to tissue during Trichinella spiralis infection DOI Creative Commons
Yiqi Liu,

Simeng Zhao,

Suqin Du

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114861 - 114861

Published: Oct. 16, 2024

Language: Английский

Citations

0
The gut microbiota is essential for Trichinella spiralis—Evoked suppression of colitis DOI Creative Commons
Hualei Sun, S. Long, Miao Jiang

et al.

PLoS neglected tropical diseases, Journal Year: 2024, Volume and Issue: 18(11), P. e0012645 - e0012645

Published: Nov. 4, 2024

Background Inflammatory bowel disease (IBD) increases the risk of colorectal cancer, and it has potential to diminish quality life. Clinical experimental evidence demonstrate protective aspects parasitic helminth infection against IBD. However, studies on inhibition inflammation by have overlooked a key determinant health: gut microbiota. Although with helminths induces alterations in host microbiota composition, influence mechanism infections induced changes development IBD not yet been elucidated. In this study, we analyzed intersection Trichinella spiralis bacteria regulation colitis related mechanisms. Methodology/Principal findings T . infected mice were treated antibiotics or cohoused wild type mice, then challenged dextran sodium sulfate (DSS)-colitis severity, immune responses goblet cells assessed. Gut composition was assessed 16S rRNA sequencing short-chain fatty acids (SCFAs) measured. We found that protection abrogated antibiotic treatment, cohousing - suppressed DSS-colitis mice. Bacterial community profiling revealed an increase abundance bacterial genus Muribaculum unclassified_Muribaculaceae Metabolomic analysis demonstrated significantly increased propionic acid feces from Data also showed microbiome modulated exhibited enhanced cell differentiation elevated IL-10 levels Conclusions These identify as critical component anti- colitic effect gives beneficial insights into processes which alleviates colitis.

Language: Английский

Citations

0
Biological characteristics of a new long-chain fatty acid transport protein 1 from Trichinella spiralis and its participation in lipid metabolism, larval moulting, and development DOI Creative Commons

Yang Li Li,

Qi Lu,

Wen Wen Zheng

et al.

Veterinary Research, Journal Year: 2024, Volume and Issue: 55(1)

Published: Sept. 30, 2024

Language: Английский

Citations

0