Methods in enzymology on CD-ROM/Methods in enzymology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4217 - 4223
Published: March 21, 2024
Abstract Healthy longevity medicine integrates geroscience and other disciplines into clinical settings, aiming to optimize health throughout one’s lifespan. Multiple factors have led increased consumer engagement, with private clinics currently meeting the demand for guidance improve healthy longevity. The establishment of in publicly funded hospitals is a significant development, making longevity-focused healthcare more accessible. These rely on multidisciplinary teams physicians allied professionals. Diagnostics involve comprehensive evaluations medical history, physical examinations, various tests detect early signs age-related functional decline. Interventions encompass lifestyle modifications, supplements, repurposed drugs, social environmental interventions. Collaboration research institutions industry partners crucial advancing creating standardized protocols. In this article, we review process public ensure best possible care individuals pursuing
Language: Английский
Citations
6
Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11
Published: April 6, 2023
Spermidine is a naturally occurring polyamine compound found in semen. It also several plant sources and boasts remarkable biological profile, particularly with regards to its anticancer properties. specifically interferes the tumour cell cycle, resulting inhibition of tumor proliferation suppression growth. Moreover, it triggers autophagy by regulating key oncologic pathways. The increased intake polyamines, such as spermidine, can suppress oncogenesis slow growth tumors due role immunosurveillance regulation metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays critical homeostasis serves diagnostic marker human cancers. Chemically modified derivatives spermidine hold great potential for prognostic, diagnostic, therapeutic applications against various malignancies. This review discusses detail recent findings that support mechanisms molecular physiology.
Language: Английский
Citations
13
Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 98(3), P. 837 - 857
Published: March 12, 2024
A hypothesis of Alzheimer’s disease etiology is proposed describing how cellular stress induces excessive polyamine synthesis and recycling which can disrupt nucleoli. Polyamines are essential in nucleolar functions, such as RNA folding ribonucleoprotein assembly. Changes the pool anionic cationic polyamines acting counterions cause significant dynamics. Polyamine reduces S-adenosylmethionine which, at low levels, triggers tau phosphorylation. Also, acetyl-CoA needed for acetylcholine, disease. Extraordinary expansion and/or contraction epigenetic control peri-nucleolar chromatin, chromosome 14 with presenilin-1 gene; 21 amyloid precursor protein 17 19 APOE4 inactive X (Xi; aka “nucleolar satellite”) normally silent spermine synthase (polyamine synthesis) spermidine/spermine-N1-acetyltransferase recycling) alleles. Chromosomes 17, Xi have high concentrations Alu elements be transcribed by polymerase III if positioned nucleosomes displaced from elements. sudden flood transcripts competitively bind nucleolin usually bound to sequences structural RNAs that stabilize heterochromatic shell. This competition leads loss integrity leaking aggregation phosphorylated tau. The was developed key word searches (e.g., PubMed) using relevant terms Alzheimer’s, lupus, nucleolin) based on a systems biology approach exploring autoimmune tautology, gaining synergistic insights other diseases.
Language: Английский
Citations
5
Food & Function, Journal Year: 2023, Volume and Issue: 14(4), P. 2149 - 2161
Published: Jan. 1, 2023
Lifespan longevity has attracted increasing attention with societal development. To counter the effects of aging on longevity, we focused natural chemicals plants. In this study, investigated puerarin supplementation lifespan Drosophila melanogaster. Puerarin significantly extended D. melanogaster at 60 μM and 120 by upregulating proteasome subunit beta 5 (prosbeta5) sirtuin-1 (Sirt1). However, puerarin-induced male flies (F0 generation) may not be passed to descendants. Additionally, a diet for 10 25 days did influence body weight food intake Canton-S flies. improved climbing ability, starvation resistance, oxidation resistance expression Shaker, catalase (CAT), superoxide dismutase 1 (SOD1), Methuselah, downregulating poly [ADP-ribose] polymerase (PARP-1) major heat shock 70 kDa protein Aa (HSP70). Moreover, increased adenosine 5' triphosphate (ATP) content 5'-monophosphate (AMP)-activated kinase (AMPK) levels. suppressed fecundity in decreasing levels Bam Punt. Mechanistically, enhanced lysosome-involved autophagy promoting lysosome markers [β-galactosidase lysosomal associated membrane (LAMP1)], elevating autophagy-related genes, including autophagy-associated gene (ATG1), ATG5, ATG8b. decreased phosphorylation target rapamycin (TOR) protein. conclusion, is promising compound improving activating autophagy.
Language: Английский
Citations
11
Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 679 - 708
Published: July 10, 2023
Language: Английский
Citations
11
Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 409, P. 135573 - 135573
Published: March 2, 2024
Language: Английский
Citations
4
JACC Basic to Translational Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Aortic stenosis (AS) is a severe heart valve disease marked by calcification, leading to failure. This study examined mitochondrial function in human aortic interstitial cells isolated from patients with AS and tested spermidine, an autophagy inducer as treatment. Spermidine treatment reduced fibrosis calcification improved these features spermidine-treated mice. The AKT-TP53-DNMT1-PPARG pathway was implicated, DNA methyltransferase 1 inhibition 5-azacytidine enhanced biogenesis reducing hypermethylation. These findings suggest that spermidine or could prevent improving function.
Language: Английский
Citations
0
Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: 9, P. 100280 - 100280
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404
Published: March 12, 2025
Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.
Language: Английский
Citations
0
Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110360 - 110360
Published: March 1, 2025
Language: Английский
Citations
0