Journal of Ayurveda and Integrative Medicine,
Journal Year:
2025,
Volume and Issue:
16(1), P. 101041 - 101041
Published: Jan. 1, 2025
Multi-targeted
drug
therapy
has
received
substantial
attention
for
the
treatment
of
diseases
multi-factorial
origin,
including
neurodegenerative
and
autoimmune
diseases.
It
seems
reasonable
to
argue
that
complex
pathology
(ND)
cannot
be
reduced
a
single
target
modulate
broad
range
cellular
signaling,
associated
pathologies,
symptoms.
is
this
idea
brought
scientific
world
towards
phytochemicals
traditional
drugs
are
notoriously
multi-targeted.
A
systematic
study
these
formulations
establishing
molecular
pathways
individual
molecules
can
lead
standardized
multi-component
product
activities
on
different
targets
ND.
This
could
provide
an
accessible
affordable
solution
significant
disease
burden
With
in
mind,
review
was
carried
out
Ayurvedic
Manasamitra
Vatakam
(MMV),
known
neuroprotective
formulation
highly
effective
against
Alzheimer's
disease.
MMV
source
phytomolecules
treating
The
multifactorial
nature
makes
them
suitable
candidates
testing
due
inherent
multitargeting
capabilities
compounds.
primary
objective
comprehensive
understanding
from
responsible
its
multitargeted
effect
From
reported
literature,
it
clear
many
phytoconstituents
extracts
herbal
ingredients
have
demonstrated
their
efficacy
AD
models.
However,
combination
models
never
been
tested.
Scientific
studies
should
done
explore
bioactive
compounds
druggability
identified
evaluated
using
experimental
methods.
Seminars in Immunology,
Journal Year:
2023,
Volume and Issue:
69, P. 101802 - 101802
Published: July 7, 2023
The
multifaceted
microbiota
characterizing
our
gut
plays
a
crucial
role
in
maintaining
immune,
metabolic
and
tissue
homeostasis
of
the
intestine
as
well
distal
organs,
including
central
nervous
system.
Microbial
dysbiosis
is
reported
several
inflammatory
intestinal
diseases
characterized
by
impairment
epithelial
vascular
barriers,
defined
leaky
gut,
it
potential
danger
condition
associated
with
development
metabolic,
neurodegenerative
diseases.
Recently,
we
pointed
out
strict
connection
between
brain
via
novel
axis.
Here
want
to
deepen
knowledge
on
gut-brain
axis,
particular
emphasis
microbial
dysbiosis,
cerebral
firm
association
axis
will
be
summarized
context
protection,
amelioration
or
boosting
Alzheimer,
Parkinson,
Major
depressive
Anxiety
disorders.
Understanding
relationship
disease
pathophysiology,
mucosal
barrier
function
host-microbe
interaction
foster
use
microbiome
biomarker
for
health
target
therapeutic
nutritional
advances.
The EMBO Journal,
Journal Year:
2023,
Volume and Issue:
42(17)
Published: July 10, 2023
Abstract
Accumulating
evidence
indicates
that
gut
microbiota
dysbiosis
is
associated
with
increased
blood–brain
barrier
(BBB)
permeability
and
contributes
to
Alzheimer's
disease
(AD)
pathogenesis.
In
contrast,
the
influence
of
on
blood‐cerebrospinal
fluid
(CSF)
has
not
yet
been
studied.
Here,
we
report
mice
lacking
display
blood‐CSF
disorganized
tight
junctions
(TJs),
which
can
be
rescued
by
recolonization
or
supplementation
short‐chain
fatty
acids
(SCFAs).
Our
data
reveal
important
only
for
establishment
but
also
maintenance
a
barrier.
Also,
vagus
nerve
plays
an
role
in
this
process
SCFAs
independently
tighten
Administration
App
NL‐G‐F
improved
subcellular
localization
TJs
at
barrier,
reduced
β‐amyloid
(Aβ)
burden,
affected
microglial
phenotype.
Altogether,
our
results
suggest
modulating
administering
might
have
therapeutic
potential
AD
via
tightening
maintaining
activity
Aβ
clearance.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
71, P. 103092 - 103092
Published: Feb. 16, 2024
In
this
review,
we
explore
how
short-chain
fatty
acids
(SCFAs)
produced
by
the
gut
microbiome
affect
Parkinson's
disease
(PD)
through
their
modulatory
interactions
with
alpha-synuclein,
neuroinflammation,
and
oxidative
stress
mediated
reactive
oxygen
nitrogen
species
(ROS/RNS).
particular,
SCFAs-such
as
acetate,
propionate,
butyrate-are
involved
in
gut-brain
communication
can
modulate
alpha-synuclein
aggregation,
a
hallmark
of
PD.
The
patients
PD
has
lower
levels
SCFAs
than
healthy
individuals.
Probiotics
may
be
potential
strategy
to
restore
alleviate
symptoms,
but
underlying
mechanisms
are
not
fully
understood.
Also
discuss
present
guts
brains
PD,
induce
neuroinflammation
via
ROS/RNS.
Alpha-synuclein
is
considered
an
early
biomarker
for
link
axis
pathogenesis.
Therefore,
elucidating
role
impact
on
alpha-synuclein-induced
microglia
ROS/RNS
crucial
pathogenesis
treatment.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(2)
Published: Nov. 22, 2023
Numerous
studies
have
described
the
notable
impact
of
gut
microbiota
on
brain
in
Alzheimer's
disease
(AD)
via
–
axis.
However,
molecular
mechanisms
underlying
involvement
development
AD
are
limited.
This
study
aimed
to
explore
potential
by
integrating
multi-omics
data.
In
this
study,
APP/PS1
and
WT
mice
at
nine
months
age
were
used
as
mouse
model.
Cognitive
function
was
assessed
using
Morris
water
maze
test.
The
levels
Aβ
plaque
neuroinflammation
detected
immunofluorescence
PET/CT.
addition,
we
not
only
16S
rRNA
gene
sequencing
metabolomics
variation
characteristics
serum
metabolism
abundance,
but
also
combined
spatial
transcriptomics
change
identify
their
correlation.
showed
significant
cognitive
impairment
amyloid-β
deposits
brain.
abundance
significantly
changed
mice,
including
decreased
Desulfoviobrio,
Enterococcus,
Turicibacter,
Ruminococcus
increased
Pseudomonas.
integration
untargeted
that
glycerophospholipid
a
common
alteration
pathway
mice.
Significant
proliferation
activation
astrocyte
microglia
observed
accompanied
alterations
immune
pathways.
Integration
analysis
fecal
transplantation
(FMT)
intervention
revealed
association
microbiota,
host
metabolism,
Molecular Neurodegeneration,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: April 16, 2024
Abstract
Trillions
of
intestinal
bacteria
in
the
human
body
undergo
dynamic
transformations
response
to
physiological
and
pathological
changes.
Alterations
their
composition
metabolites
collectively
contribute
progression
Alzheimer’s
disease.
The
role
gut
microbiota
disease
is
diverse
complex,
evidence
suggests
lipid
metabolism
may
be
one
potential
pathways.
However,
mechanisms
that
mediate
pathology
remain
unclear,
necessitating
further
investigation
for
clarification.
This
review
highlights
current
understanding
how
disrupts
discusses
implications
these
discoveries
guiding
strategies
prevention
or
treatment
based
on
existing
data.
Experimental Gerontology,
Journal Year:
2024,
Volume and Issue:
194, P. 112497 - 112497
Published: June 27, 2024
The
gut
microbiome
plays
a
crucial
role
in
host
health
throughout
the
lifespan
by
influencing
brain
function
during
aging.
microbial
diversity
of
human
decreases
aging
process
and,
as
consequence,
several
mechanisms
increase,
such
oxidative
stress,
mitochondrial
dysfunction,
inflammatory
response,
and
dysbiosis.
Moreover,
evidence
indicates
that
neurodegeneration
are
closely
related;
consequently,
may
serve
novel
marker
elderly.
In
this
narrative
study,
we
investigated
how
changes
composition
occur
influence
to
various
neuropathological
disorders,
mild
cognitive
impairment
(MCI),
dementia,
Alzheimer's
disease
(AD),
Parkinson's
(PD);
which
possible
govern
relationship
between
impairment.
addition,
studies
suggest
be
potential
target
improve
hallmarks
promote
healthy
cognition;
therefore,
current
future
therapeutic
interventions
have
been
also
reviewed.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7621 - 7621
Published: July 11, 2024
Multiple
organs
and
tissues
coordinate
to
respond
dietary
environmental
challenges.
It
is
interorgan
crosstalk
that
contributes
systemic
metabolic
homeostasis.
The
liver
brain,
as
key
organs,
have
their
unique
dialogue
transmit
messages.
interconnected
pathogenesis
of
brain
implicated
in
numerous
neurodegenerative
disorders.
Recent
insights
positioned
the
not
only
a
central
hub
but
also
an
endocrine
organ,
capable
secreting
hepatokines
signals
throughout
body
via
bloodstream.
Metabolites
from
or
gut
microbiota
facilitate
complex
between
brain.
In
parallel
humoral
factors,
neural
pathways,
particularly
hypothalamic
nuclei
autonomic
nervous
system,
are
pivotal
modulating
bilateral
interplay
cerebral
hepatic
compartments.
term
“liver–brain
axis”
vividly
portrays
this
interaction.
At
end
review,
we
summarize
cutting-edge
technical
advancements
enabled
observation
manipulation
these
signals,
including
genetic
engineering,
molecular
tracing,
delivery
technologies.
These
innovations
paving
way
for
deeper
understanding
liver–brain
axis
its
role
