Chronic inflammation and the hallmarks of aging

Molecular Metabolism, Journal Year: 2023, Volume and Issue: 74, P. 101755 - 101755

Published: June 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Language: Английский

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Endothelial dysfunction: molecular mechanisms and clinical implications

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 22, 2024

Abstract Cardiovascular disease (CVD) and its complications are a leading cause of death worldwide. Endothelial dysfunction plays crucial role in the initiation progression CVD, serving as pivotal factor pathogenesis cardiovascular, metabolic, other related diseases. The regulation endothelial is influenced by various risk factors intricate signaling pathways, which vary depending on specific context. Despite numerous research efforts aimed at elucidating mechanisms underlying dysfunction, precise molecular pathways involved remain incompletely understood. This review elucidates recent findings pathophysiological including nitric oxide availability, oxidative stress, inflammation‐mediated pathways. We also discuss impact pathological conditions, atherosclerosis, heart failure, diabetes, hypertension, chronic kidney disease, neurodegenerative Furthermore, we summarize traditional novel potential biomarkers well pharmacological nonpharmacological therapeutic strategies for protection treatment CVD complications. Consequently, this to improve understanding emerging approaches reducing developing associated complications, mitigating dysfunction.

Language: Английский

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New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15160 - 15160

Published: Oct. 13, 2023

Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to endogenous hazard signals metabolites in circulatory system. The senescence death ECs not only adverse outcomes, but also causal contributors endothelial dysfunction, an early risk marker atherosclerosis. pathophysiological process EC involves both structural functional changes has been linked various factors, including oxidative stress, dysregulated cell cycle, hyperuricemia, vascular inflammation, aberrant metabolite sensing signaling. Multiple forms have documented atherosclerosis, autophagic death, apoptosis, pyroptosis, NETosis, necroptosis, ferroptosis. Despite this, molecular mechanisms underlying or atherogenesis fully understood. To provide a comprehensive update on subject, this review examines historic latest findings alterations associated with different stages

Language: Английский

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The crosstalk between Nrf2 and NF-κB pathways in coronary artery disease: Can it be regulated by SIRT6?

Life Sciences, Journal Year: 2023, Volume and Issue: 330, P. 122007 - 122007

Published: Aug. 5, 2023

Language: Английский

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SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Jan. 31, 2024

Abstract Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis highly orchestrated defined by sequences of cellular response molecular signals mechanisms underlying disease. In pathophysiologic conditions associated with organ fibrosis, variety injurious stimuli such as metabolic disorders, epigenetic changes, aging may induce progression fibrosis. Sirtuins protein kind deacetylase which can regulate cell metabolism participate in physiological functions. this review, we outline our current understanding common principles fibrogenic functional role SIRT3/6 addition, novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, highlight biological function focus on well their inhibitors activators preventative therapeutic interventions for tissue Graphical abstract

Language: Английский

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Epigenetic biomarkers in aging and longevity: Current and future application

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122842 - 122842

Published: June 13, 2024

Language: Английский

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SIRT6 promotes angiogenesis by enhancing VEGFA secretion via demyristoylation in endothelial cell

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107462 - 107462

Published: Jan. 1, 2025

Language: Английский

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The role of sirtuins in the regulation of reactive oxygen species in myocardial ischemia/reperfusion injury

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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Nuclear receptor coactive 4-mediated ferritinophagy: a key role of heavy metals toxicity

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

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