Endoplasmic reticulum stress-mediated cell death in cardiovascular disease

Cell Stress and Chaperones, Journal Year: 2024, Volume and Issue: 29(1), P. 158 - 174

Published: Jan. 29, 2024

The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis. Endoplasmic stress (ERS) can trigger various modes of cell death by activating the unfolded protein response (UPR) signaling pathway. Cell crucial role occurrence and development diseases such as cancer, liver diseases, neurological cardiovascular diseases. Several including hypertension, atherosclerosis, heart failure are associated with ER stress. stress-mediated is interest disease. Moreover, an increasing body evidence supports potential modulating ERS for treating This paper provides comprehensive review UPR pathway, mechanisms that induce death, Additionally, we discuss common along therapeutic strategies.

Language: Английский

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Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1978 - 1978

Published: Feb. 6, 2024

Endothelial cells line at the most inner layer of blood vessels. They act to control hemostasis, arterial tone/reactivity, wound healing, tissue oxygen, and nutrient supply. With age, endothelial become senescent, characterized by reduced regeneration capacity, inflammation, abnormal secretory profile. senescence represents one earliest features ageing contributes many age-related diseases. Compared those in arteries veins, microcirculation exhibit a greater extent heterogeneity. Microcirculatory leads declined capillary density, angiogenic potentials, decreased flow, impaired barrier properties, hypoperfusion or organ-dependent manner. The heterogeneous phenotypes microvascular particular vascular bed across different tissues remain largely unknown. Accordingly, mechanisms underlying macro- micro-vascular vary pathophysiological conditions, thus offering specific target(s) for therapeutic development senolytic drugs.

Language: Английский

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The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1469 - 1469

Published: Sept. 1, 2024

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known be longevity regulators, and exerts a key role in prevention of vascular aging. By aging, expression levels Sirt1 decline with severe impact on function, such as rise endothelial dysfunction, which turn promotes development cardiovascular diseases. In this context, activity preventing senescence is particularly important. Given counteracting senescence, great efforts have been made deepen knowledge about intricate cross-talks interactions other molecules, order set up possible strategies boost prevent or treat The aim review provide proper background regulation function endothelium discuss recent advances regarding therapeutic targeting counteract

Language: Английский

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Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107462 - 107462

Published: Jan. 1, 2025

Language: Английский

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Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 5, 2024

Modern human society is burdened with the pandemic of cardiovascular and metabolic diseases. Metrnl a widely distributed secreted protein in body, involved regulating glucose lipid metabolism maintaining system homeostasis. In this review, we present predictive therapeutic roles various diseases, including atherosclerosis, ischemic heart disease, cardiac remodeling, failure, hypertension, chemotherapy-induced myocardial injury, diabetes mellitus, obesity.

Language: Английский

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Endothelial Cell Dysfunction: Onset, Progression, and Consequences

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6), P. 223 - 223

Published: June 20, 2024

Endothelial cell dysfunction is a complex process involving various causes, early and late events, subsequent consequences. This review provides an overview of each aspect outlines therapeutic interventions targeting these stages. Causes endothelial encompass spectrum risk factors including hypertension, diabetes, smoking, obesity, inflammation, oxidative stress, genetic predispositions. Early events such as activation, inflammatory response, dysregulated vasomotor tone precede like apoptosis, microvascular rarefaction. The consequences include remodelling, neovascularization, organ dysfunction, clinical manifestations, highlighting the diverse impacts across multiple systems. While depicted linearly, progression dynamic, influenced by underlying cause affected vascular bed. Understanding dynamics crucial for tailoring interventions, ranging from lifestyle modifications to targeted therapies, address causes effects effectively. Here we provide comprehensive understanding that essential developing strategies mitigate impact this dysregulation on health cardiovascular diseases progression.

Language: Английский

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Biomimetic Nanoparticles for the Diagnosis and Therapy of Atherosclerosis

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(9)

Published: Aug. 15, 2024

Atherosclerosis (AS) is a chronic inflammation of blood vessels, which often has no obvious symptoms in the early stage disease, but when atherosclerotic plaques are formed, they cause lumen blockage, and even plaque rupture leads to thrombosis, that essential factor cardiovascular events, for example myocardial infarction, cerebral renal atrophy. Therefore, it considerably significant recognition precise therapy plaque. Biomimetic nanoparticles (BNPs), especially those coated with cell membranes, can retain biological function membranes or cells, led extensive research application diagnosis treatment AS recent years. In this review, we summarized roles various key cells progression, construction biomimetic based on these as well their applications therapy. Furthermore, give challenge prospect AS, hoping elevate quality possibility clinical translation.

Language: Английский

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Functions and application of circRNAs in vascular aging and aging-related vascular diseases

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 17, 2025

Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding generated through the reverse splicing mRNA precursors, possess capacity to regulate gene transcription and translation. Recently, pivotal role circRNAs in controlling vascular aging, as well pathogenesis progression aging-related diseases, has garnered substantial attention. Vascular aging plays crucial increased morbidity mortality elderly. Endothelial cells (ECs) smooth muscle (VSMCs) are components intima media layers wall, respectively, closely involved mechanisms underlying diseases. The review aims provide comprehensive exploration connection between Besides, circRNAs, potential diagnostic markers or therapeutic targets for will be discussed thoroughly, along with challenges limitations their clinical application. Investigating molecular diseases insight into early diagnosis therapy, even effective prognosis assessment these conditions.

Language: Английский

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Reactive Carbonyl Species and Protein Lipoxidation in Atherogenesis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 232 - 232

Published: Feb. 14, 2024

Atherosclerosis is a multifactorial disease of medium and large arteries, characterized by the presence lipid-rich plaques lining intima over time. It main cause cardiovascular diseases death worldwide. Redox imbalance lipid peroxidation could play key roles in atherosclerosis promoting bundle responses, including endothelial activation, inflammation, foam cell formation. The oxidation polyunsaturated fatty acids generates various products such as reactive carbonyl species (RCS), 4-hydroxy alkenals, malondialdehyde, acrolein. RCS covalently bind to nucleophilic groups nucleic acids, phospholipids, proteins, modifying their structure activity leading progressive dysfunction. Protein lipoxidation non-enzymatic post-translational modification proteins RCS. Low-density lipoprotein (LDL) apolipoprotein B (apoB) major role Moreover, oxidized LDLs are source RCS, which form adducts on huge number depending oxidative stress intensity, nature targets, availability detoxifying systems. Many systems affected lipoxidation, extracellular matrix components, membranes, cytoplasmic cytoskeletal transcription factors, other components. mechanisms involved lipoxidation-induced vascular dysfunction not fully elucidated. In this review, we focus protein during atherogenesis.

Language: Английский

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Targeting vascular senescence in cardiovascular disease with aging

The Journal of Cardiovascular Aging, Journal Year: 2024, Volume and Issue: 4(2)

Published: Feb. 29, 2024

Aging is a major risk factor for atherosclerosis and cardiovascular disease (CVD). Two age-associated arterial phenotypes, endothelial dysfunction large elastic stiffness, are autonomous predictors of future CVD diagnosis contribute to the progression in older adults. Senescent cells lose capacity proliferate but remain metabolically active secrete inflammatory factors termed senescence-associated secretory phenotype (SASP), leading an increase inflammation oxidative stress. Accumulation senescent linked with age-related diseases has been known play role disease. In this brief review, we describe characteristics mechanisms cell accumulation how promote stiffness. We focus on range novel therapeutic strategies aimed at reducing burden through targeting cells. Studies have begun investigate specific class drugs that able selectively eliminate cells, senolytics, which shown great promise reversing aging ameliorating pathologies disorders, creating new opportunity research. Generating therapies elimination would improve health span longevity, making senolytics promising therapy diseases.

Language: Английский

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