Published: Jan. 1, 2024
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1994 - 1994
Published: Sept. 2, 2024
Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology depression is complex influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated development depression, particular focus on role obesity. literature search was conducted PubMed, Embase, PsycINFO from May July 2024. highlights impact environmental conditions; lifestyle choices, physical activity dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical psychological hormone fluctuations; epigenetic depression. A key emphasis placed inflammatory processes linked obesity, which may drive bidirectional relationship between findings suggest that an increased risk potentially due chronic inflammation, neurochemical dysregulation, emotional social challenges related weight stigma management. Understanding these interconnected important for developing targeted interventions address both leading improved quality life those affected.
Language: Английский
Citations
7
Metabolism, Journal Year: 2024, Volume and Issue: 161, P. 156052 - 156052
Published: Oct. 28, 2024
Language: Английский
Citations
7
Neurobiology of Aging, Journal Year: 2025, Volume and Issue: 147, P. 176 - 186
Published: Jan. 7, 2025
Language: Английский
Citations
1
Post Reproductive Health, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
We attempted to assess Menopause-Specific Quality of Life (MENQOL) and attitude towards menopause with respect ‘years after menopause’ also association between MENQOL menopause. One hundred eighty-two Bengali Hindu postmenopausal women (aged 42 65 years) living in Kolkata, India participated the study. Data on socio-demographic, reproductive characteristics, MENQOL, were collected. Results revealed that botheration symptoms related vasomotor sexual domains remained significantly higher among participants within 3 years menopause, while physical psychosocial impairment likely increase menopause’. Participants who attained less than ago had positive those more ago. Hierarchical linear regression suggested score was inversely associated domain, but positively educational levels occupational types participants. conclude reported impaired developed negative After controlling confounders, only domain showed strong
Language: Английский
Citations
1
BMC Ecology and Evolution, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 24, 2025
Abstract The pace of life (POL) is shaped by a complex interplay between genetic and environmental factors, influencing growth, maturation, lifespan across species. Hippo signaling pathway, key regulator organ size cellular homeostasis, has emerged as central integrator cues that modulate POL traits. In this review, we explore how the pathway links factors—such temperature fluctuations dietary energy availability—to molecular mechanisms governing metabolic balance, hormonal signaling, reproductive timing. Specifically, highlight regulatory interactions sensors (AMPK, mTOR, SIRT1 DLK1-Notch), well signals (IGF-1, kisspeptin, leptin, cortisol, thyroid sex steroids), which together orchestrate life-history traits, including growth rates, sexual with particular emphasis on their role in Furthermore, consider its potential coordinator POL-related processes, such telomere dynamics epigenetic mechanisms, within broader network. By integrating insights from biology eco-evolutionary perspectives, propose future directions to dissect pathway’s regulation taxa. Understanding these will provide new perspectives organisms adaptively adjust strategies response variability.
Language: Английский
Citations
1
Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(10), P. 8289 - 8308
Published: Oct. 12, 2023
The hypothalamus is an important regulator of autonomic and endocrine functions also involved in aging regulation. process the accompanied by disturbed intracellular signaling including insulin/insulin-like growth factor-1 (IGF-1)/growth hormone (GH), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT)/the mammalian target rapamycin (mTOR), mitogen activated protein (MAPK), janus (JAK)/signal transducer activator transcription (STAT), AMP-activated (AMPK), nuclear factor kappa-light-chain-enhancer cells (NF-ĸB), nitric oxide (NO). In current review, I have summarized understanding changes above-mentioned pathways with a focus on hypothalamic alterations.
Language: Английский
Citations
10
Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: Feb. 5, 2025
Language: Английский
Citations
0
European Journal of Medical and Health Research, Journal Year: 2025, Volume and Issue: 3(1), P. 139 - 144
Published: Jan. 1, 2025
Background: Oral essential amino acid (EAA) ingestion is popular due to its potential growth and health advantages. The body cannot synthesise these acids, so they must be ingested for protein synthesis, muscle repair metabolic function, which are physiological functions, especially development in children adolescents. aim of this study was investigate the effects oral EAA on GH levels healthy under 18 years age demonstrate as a dietary intervention adolescent growth. Methods: Essential acids were tested hormone (GH) under-18s using randomised, blinded, controlled approach. Each 50-person supplementation control group gender balanced. Females had higher than males, while females lower levels. Post-supplementation not significantly correlated with age, showing that does influence response supplementation. Results: 100-person, sex-balanced compared placebo Amino increased (P=0.0001), whereas slightly (P=0.005). women men (P=0.047), but did affect age-GH association (R=-0.17, P=0.2). Conclusions: This demonstrated significant increase class, particularly females, suggesting there may sex differences way regulated. results show increasing lysine tryptophan areas have beneficial effect
Language: Английский
Citations
0
Journal of Geriatric Oncology, Journal Year: 2024, Volume and Issue: 15(7), P. 101833 - 101833
Published: July 14, 2024
Language: Английский
Citations
1
Life, Journal Year: 2024, Volume and Issue: 14(6), P. 772 - 772
Published: June 17, 2024
Primary amenorrhea, the absence of menstruation by age 15, can have significant implications for reproductive health and overall well-being. This retrospective study aimed to evaluate effectiveness various management strategies primary amenorrhea among women in Saudi Arabia. Medical records 63 eligible patients from 2018 2023 were analyzed, assessing diagnostic methods, treatment modalities, associated outcomes. The findings revealed that hormonal therapy was most commonly employed strategy (50.0%) demonstrated highest rate achieving menstrual regularity (62.5%). Surgical interventions utilized 28.1% cases, with a 50.0% symptom resolution. Lifestyle modifications less frequent (21.9%) but showed moderate resolution (35.7%). Logistic regression analysis identified age, underlying etiology, as predictors success. Subgroup analyses highlighted efficacy lifestyle genetic etiologies, while surgical more effective anatomical causes. underscores importance comprehensive approach personalized plans tailored individual patient characteristics. Despite limitations, contribute understanding optimal emphasize need multidisciplinary collaboration addressing this complex condition.
Language: Английский
Citations
0