Gut microbiota: an ideal biomarker and intervention strategy for aging DOI Open Access
Xuan Xu, Tang-Chang Xu, Jing Wei

et al.

Microbiome Research Reports, Journal Year: 2023, Volume and Issue: 3(2)

Published: Dec. 25, 2023

Population aging is a substantial challenge for the global sanitation framework. Unhealthy tends to be accompanied by chronic diseases such as cardiovascular disease, diabetes, and cancer, which undermine welfare of elderly. Based on fact that inevitable but retarding attainable, flexible characterization efficient anti-aging become imperative healthy aging. The gut microbiome, most dynamic component interacting with organism, can affect process through its own structure metabolites, thus holding potential both an ideal aging-related biomarker intervention strategy. This review summarizes value applying microbiota microbial biomarkers in diagnosing state monitoring effect interventions, ultimately pointing future prospects strategies maintaining

Language: Английский

Akkermansia muciniphila-derived extracellular vesicles mitigate smoking-induced prostate inflammation and fibrosis DOI
Sheng Zhu, Yiyi Wang, Xinyue Hu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114195 - 114195

Published: Feb. 3, 2025

Language: Английский

Citations

1
Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma DOI Creative Commons
Yanguang Yang, Xinli Shi

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving

Language: Английский

Citations

1
Dietary Live Microbes Intake Associated With Biological Aging and Mortality DOI
Xu Zhu, Wenhang Chen,

Jing Xue

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(11)

Published: Aug. 19, 2024

Abstract This observational study aimed to investigate associations between dietary live microbe intake and mortality, as well biological aging. Adults from the 1999–2018 National Health Nutrition Examination Survey were categorized into low, medium, high groups. Foods with medium content aggregated a medium-high consumption category. The outcomes included all-cause, cardiovascular, cancer along age (BA) acceleration assessed by Klemera–Doubal method (KDM) PhenoAge. Multiple regression analyses mediation conducted assess associations, adjusting for potential confounders. A total of 34 133 adults in our analyses. Over an average follow-up period 9.92 years, 5 462 deaths occurred. In multivariate adjusted models, every 100 g group foods consumed was associated reduced all-cause mortality (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.91 0.97, p < .001) cardiovascular (HR 0.91, CI 0.86 0.96, .001), but not 1.01, 0.95 1.07, = .768). Every decreased KDM-BA (fully coefficient −0.09, −0.15 −0.04, PhenoAge −0.07, −0.11 −0.03, .001). Mediation analysis showed that BA partially mediated microbes-mortality associations. Our results suggest higher is lower risk slower However, further research needed verify these findings.

Language: Английский

Citations

5
Akkermansia muciniphila and herbal medicine in immune-related diseases: current evidence and future perspectives DOI Creative Commons
Xue Ding,

Pengfei Meng,

Xiuxia Ma

et al.

Frontiers in Microbiomes, Journal Year: 2024, Volume and Issue: 3

Published: Feb. 5, 2024

Akkermansia muciniphila is considered the “paradigm for next-generation beneficial microorganisms” and has been reported to help alleviat immune-related diseases. Evidence shows that herbal medicine can treat disease by regulating abundance of A. . Recent studies have revealed a link between Here, we systematically reviewed association , medicine, diseases (including inflammatory bowel disease, human immunodeficiency virus, cancer immunotherapy, liver injury). We also summarize potential mechanisms action offer perspectives future studies.

Language: Английский

Citations

4
Aging: an inevitable road toward gut microbiota pathoadaptation DOI Open Access
Rita Melo-Miranda, Ana Paula Pinto, Hugo C. Barreto

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

SUMMARY Laboratory-raised mice live approximately seven times longer and healthier lives compared to their wild counterparts, due a standardized healthy diet limited exposure environmental stressors 1 . Aging is associated with increased inflammation microbial dysbiosis 2–4 Collectively, these influence microbiota evolution may contribute the enrichment in pathobiont frequency observed old age 4 Alternatively, this increase could stem from decline colonization resistance 5,6 , creating favorable conditions for invasion. Here, we sought test whether aging healthy, controlled conditions, prevent selection of age-associated pathobionts. We have followed adaptive commensal strain Escherichia coli guts advanced found that it acquired several mutations common bacteria colonizing young mice, which were absent animals. This, together Akkermansia muciniphila age, suggest 7,8 However, exclusively older mainly pathoadaptive, tuning metabolism oxygen iron availability, hypermotility, biofilm formation. In summary, while evolutionary signature very shows youth-like features be longevity, pathoadaptive traits magnified age. While suggesting breach not needed justify abundance pathobionts, our findings raise question specialized bacteria, as opposing generalists such E. will display same ability evolve traits. Highlights Gut commensals face increasingly personalized selective pressures gut Even selects ‘s pattern better reflects metabolome than composition Brief Pathobionts are often enriched elderly. Melo-Miranda et al. showed irrespectively limiting opportunity invasion, strength pathoadaptation increases aging. Yet, environment extreme ages seems converge, highlighting discontinuity process.

Language: Английский

Citations

0
Effect of gut symbiotic bacteria Akkermansia muciniphila on aging-related obesity DOI
Zebiao Liu,

Mingquan Chen,

Weitao Zheng

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151606 - 151606

Published: March 8, 2025

Language: Английский

Citations

0
Spaceflight redefines ageing‐associated microbiota DOI Creative Commons
Yuan Sun, Sai Liu, Long Chen

et al.

iMeta, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
Canine-derived Weissella confusa ZJUIDS-D034 and Enterococcus faecalis ZJUIDS-D016 combat aging by regulating gut microbiota DOI Creative Commons
Nan Chen, Zijia Yu, Xuan Ji

et al.

Current Research in Microbial Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 100381 - 100381

Published: March 1, 2025

Old age raises the susceptibility of age-related disease in domestic dogs. Discovering effective anti-aging interventions is key for mitigating and conserving "healthspan" pet In this study, 2 bacterial strains were isolated from canine feces. After screening identifying strains, Weissella confusa ZJUIDS-D034 Enterococcus faecalis ZJUIDS-D016 chosen to intervene during d-galactose-induced senescence mice. We found that administering improved aging phenotype mice, including an increase antioxidant activity, a decrease pro-inflammatory cytokines, restoration intestinal liver tissue damage. addition, lead changes structure microbiota Specifically, there was abundance Cyanobacteria Akkermansia Lactobacillus. More importantly, significant acetic acid, short-chain fatty due intervention with strains. This might be attributed higher Akkermansia. show modulation gut metabolism mice may promising strategy through which exert their effects.

Language: Английский

Citations

0
Impact of fecal microbiota transplantation on lung function and gut microbiome in an ARDS rat model: A multi-omics analysis including 16S rRNA sequencing, metabolomics, and transcriptomics DOI Creative Commons
Dongwei Zhang, Zhenqiang Zhang,

L. Liao

et al.

International Journal of Immunopathology and Pharmacology, Journal Year: 2025, Volume and Issue: 39

Published: March 1, 2025

Objective: Acute respiratory distress syndrome (ARDS) is a severe pulmonary condition characterized by inflammation and lung damage, frequently resulting in poor clinical outcomes. Recent studies suggest that the gut-lung axis, mediated gut microbiota, critical ARDS progression. This study investigates therapeutic potential of fecal microbiota transplantation (FMT) an rat model ( n = 6). Introduction: The pathogenesis involves complex interactions between lungs gut, with playing key role. Understanding effects FMT on function may provide new strategies for management. Methods: Sprague-Dawley rats were pre-treated broad-spectrum antibiotic cocktail to create germ-free state subsequently exposed intranasal lipopolysaccharide induce ARDS. then received treatment. Lung samples analyzed using histopathology transcriptomics. Fecal 16S rRNA sequencing metabolomics. Results: treatment significantly reduced injury improved function, as evidenced increased partial pressure arterial oxygen (PaO 2 ) decreased carbon dioxide (PaCO ). also altered composition regulating Akkermansia Lactobacillus , restoring abundance genera such Muribaculaceae Clostridia_UCG-014 Prevotella Adlercreutzia while reducing Romboutsia . restored metabolic pathways involved lipid metabolism, amino acid biosynthesis, immune regulation, including modulation like mTOR signaling. These alterations contribute function. Conclusion: findings indicate exert its beneficial modulating enhancing responses. However, given this remains preclinical stage, further validation necessary before considering application.

Language: Английский

Citations

0
Microbiome Taxonomic and Functional Differences in C3H/HeJ Mice Fed a Long-Term High-Fat Diet with Beef Protein ± Ammonium Hydroxide Supplementation DOI Open Access

Emily C. Garrison,

Amanda M. V. Brown,

McKinlee M. Salazar

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1613 - 1613

Published: May 25, 2024

Studies have suggested that alkalinized foods may reduce the effects of acidogenic Western diet in promoting obesity, metabolic syndrome, type 2 diabetes, cancer, and coronary heart disease. Indeed, a recent study mice fed high-fat containing dietary beef supplemented with ammonium hydroxide showed improvement suite outcomes. However, protein supplementation on microbiome remain unknown. In this study, towards taxa function were analyzed. Fecal microbiomes characterized using shotgun metagenomic approach for 16-month-old male female after long-term treatments. The results ammoniated diets several bacteria known to be associated health benefits increased significantly, including Romboutsia, Oscillospiraceae, Lactococcus cremoris. beneficial mucin-degrader Akkermansia was especially abundant, high prevalence (~86%) females. Concurrently, phyla Actinomycetota (Actinobacteria) Bacteroidota (Bacteroidetes) significantly reduced. While sex confounding factor affecting responses protein, it is worth noting putatively functions supplementation, such as glycine betaine transport, xenobiotic detoxification, enhanced defense, others. Conversely, many disease-associated Importantly, modifying pH alone via induced microbiota changes. Taken together, these suggest ammonium-supplemented proteins mediate some negative microbiome-associated high-fat/Western diets.

Language: Английский

Citations

3