Advances in Conductive Hydrogel for Spinal Cord Injury Repair and Regeneration

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7305 - 7333

Published: Dec. 1, 2023

Abstract: Spinal cord injury (SCI) treatment represents a major challenge in clinical practice. In recent years, the rapid development of neural tissue engineering technology has provided new therapeutic approach for spinal repair. Implanting functionalized electroconductive hydrogels (ECH) area been shown to promote axonal regeneration and facilitate generation neuronal circuits by reshaping microenvironment SCI. ECH not only intercellular electrical signaling but, when combined with stimulation, enable transmission signals electroactive activate bioelectric pathways, thereby promoting Therefore, implantation into damaged tissues can effectively restore physiological functions related conduction. This article focuses on dynamic pathophysiological changes SCI discusses mechanisms stimulation/signal process By examining activity during nerve repair, we provide insights behind stimulation We classify conductive biomaterials, offer an overview current applications research progress repair regeneration, aiming reference future explorations developments strategies. Keywords: engineering, signal,

Language: Английский

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Glycosaminoglycans: Mechanisms and Therapeutic Potential in Neurological Diseases: A Mini-Review

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151861 - 151861

Published: April 1, 2025

Language: Английский

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Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 9, 2024

Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, chronic. In each period there are different alterations in the cells, inflammatory factors, signaling spinal cord. Many biomaterials have been investigated of SCI, including hydrogels fiber scaffolds, some progress has made using multiple materials. However, limitations when individual treatment, these can be significantly improved by combining treatments with stem cells. order to better understand investigate new strategies its several combination therapies that include materials combined drugs, cytokines, etc. summarized current review.

Language: Английский

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(3), P. 660 - 670

Published: April 16, 2024

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, communities; the financial costs can be challenging families health institutions. Treatments aimed at restoring spinal after injury, which have been tested animal models or clinical trials, generally seek to counteract one more of mechanisms limit extent initial damage. Most published works on structural/functional restoration acute chronic stages use a single type treatment: drug trophic factor, transplant cell type, implantation biomaterial. Despite significant benefits reported models, when translating these successful therapeutic strategies humans, result trials has considered little relevance because improvement, present, is usually insufficient. Until now, studies designed promote neuroprotection regeneration different used treatments. Considering occurrence various sub-acute phases it reasonable speculate that than agent could required structural functional damaged cord. combine several agents, targeting which, as therapy, shown some benefits, allow us assume they will synergistic beneficial effects. Thus, narrative review article aims summarize current trends agents administered simultaneously sequentially, seeking injured

Language: Английский

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Targeting chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapeutic potential

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Language: Английский

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