Genes & Diseases,
Journal Year:
2024,
Volume and Issue:
12(4), P. 101435 - 101435
Published: Sept. 17, 2024
MYC
is
dysregulated
in
approximately
70%
of
human
cancers,
strongly
suggesting
its
essential
function
cancer.
regulates
many
biological
processes,
such
as
cell
cycle,
metabolism,
cellular
senescence,
apoptosis,
angiogenesis,
and
immune
escape.
plays
a
central
role
carcinogenesis
key
regulator
tumor
development
drug
resistance.
Therefore,
one
the
most
alluring
therapeutic
targets
for
developing
cancer
drugs.
Although
search
direct
inhibitors
challenging,
cannot
simply
be
assumed
to
undruggable.
Targeting
MYC-MAX
complex
has
been
an
effective
method
directly
targeting
MYC.
Alternatively,
indirect
represents
more
pragmatic
approach,
mainly
including
inhibition
transcriptional
or
translational
processes
MYC,
destabilization
protein,
blocking
genes
that
are
synthetically
lethal
with
overexpression.
In
this
review,
we
delineate
multifaceted
roles
progression,
highlighting
spectrum
strategies
therapy
target
either
indirectly.
Medicinal Research Reviews,
Journal Year:
2024,
Volume and Issue:
44(6), P. 2825 - 2848
Published: Aug. 9, 2024
Oxidative
DNA
damage-related
diseases,
such
as
incurable
inflammation,
malignant
tumors,
and
age-related
disorders,
present
significant
challenges
in
modern
medicine
due
to
their
complex
molecular
mechanisms
limitations
identifying
effective
treatment
targets.
Recently,
8-oxoguanine
glycosylase
1
(OGG1)
has
emerged
a
promising
multifunctional
therapeutic
target
for
the
of
these
challenging
diseases.
In
this
review,
we
systematically
summarize
multiple
functions
OGG1,
including
pro-inflammatory,
tumorigenic,
aging
regulatory
mechanisms.
We
also
highlight
potential
OGG1
inhibitors
activators
potent
agents
aforementioned
life-limiting
conclude
that
serves
hub;
inhibition
may
provide
novel
approach
preventing
treating
inflammation
cancer,
activation
could
be
strategy
disorders.
Furthermore,
an
extensive
overview
successful
applications
regulation
inflammatory,
cancerous,
aging-related
Finally,
discuss
current
future
directions
emerging
marker
The
aim
review
is
robust
reference
scientific
researchers
clinical
drug
developers
development
targeted
drugs
especially
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Aug. 30, 2024
Astragali
radix
(AR,
namded
Huangqi
in
Chinese)
is
the
dried
root
of
Astragalus
membranaceus
(Fisch.)
Bge.
var.
mongholicus
(Bge.)
Hsiao
or
As
a
widely
used
ethnomedicine,
biological
activities
AR
include
immunomodulatory,
anti-hyperglycemic,
anti-oxidant,
anti-aging,
anti-inflammatory,
anti-viral,
anti-tumor,
cardioprotective,
and
anti-diabetic
effects,
with
minimum
side
effects.
Currently,
it
known
that
polysaccharides,
saponins,
flavonoids
are
indispensable
components
AR.
In
this
review,
we
will
elaborate
research
advancements
on
ethnobotany,
ethnopharmacological
practices,
phytochemicals,
pharmacological
activities,
clinical
uses,
quality
control,
production
developments,
toxicology.
The
information
expected
to
assist
clinicians
scientists
developing
useful
therapeutic
medicines
minimal
systemic
Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Feb. 12, 2025
Abstract
In
the
past
few
years,
emergence
of
organoids
and
organ-on-a-chip
(OOAC)
technologies,
which
are
complementary
to
animal
models
two-dimensional
cell
culture
methods
can
better
simulate
internal
environment
human
body,
provides
a
new
platform
for
traditional
Chinese
medicine
(TCM)
studies.
Organoids
OOAC
techniques
have
been
increasingly
applied
in
fields
drug
screening,
assessment
development,
personalized
therapies,
developmental
biology,
there
some
application
cases
TCM
this
review,
we
summarized
current
status
using
organoid
technologies
research
provide
key
insights
future
study.
It
is
believed
that
will
play
more
important
roles
make
greater
contributions
innovative
development
TCM.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(12), P. 2727 - 2727
Published: June 7, 2024
The
toll-like
receptor
4
(TLR4)
signaling
pathway
constitutes
an
intricate
network
of
protein
interactions
primarily
involved
in
inflammation
and
cancer.
This
triggers
intracellular
cascades,
modulating
transcription
factors
that
regulate
gene
expression
related
to
immunity
malignancy.
Previous
studies
showed
colon
cancer
patients
with
low
TLR4
exhibit
extended
survival
times
the
holds
a
significant
role
CRC
pathogenesis.
In
recent
years,
traditional
Chinese
medicines
(TCMs)
have
garnered
substantial
attention
as
alternative
therapeutic
modality
for
CRC,
due
their
multifaceted
composition
ability
target
multiple
pathways.
Emerging
evidence
indicates
specific
TCM
products,
such
andrographolide,
rosmarinic
acid,
baicalin,
etc.,
potential
impede
development
through
pathway.
Here,
we
review
biochemical
processes
natural
products
from
TCMs
affecting
sheds
light
on
treatment
strategies
utilizing
inhibitors
which
contributes
advancement
research
accelerates
clinical
integration
into
treatment.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 14, 2025
MYC
gene
has
become
one
of
the
most
investigated
oncogenes
for
regulating
programmed
cell
death
and
tumor
growth.
is
a
transcription
factor
that
regulates
expression
numerous
genes
involved
in
critical
cellular
processes,
such
as
metabolism,
stress
response,
proliferation.
However,
its
dysfunction,
often
caused
by
amplifications
or
translocations,
makes
it
potent
oncogenic
driver,
contributing
to
uncontrolled
growth,
angiogenesis,
invasiveness,
metastasis.
Paradoxically,
can
promote
both
survival
elimination
through
activation
apoptotic
mechanisms,
creating
delicate
balance
between
death.
This
chapter
explores
dual
role
regulator
life
death,
analyzing
molecular
mechanisms
determine
activity
different
biological
contexts.
The
main
pathways
controlled
MYC,
contribution
plasticity,
interactions
with
other
suppressors
will
be
discussed.
Finally,
emerging
therapeutic
strategies
aimed
at
targeting
regulatory
networks
reviewed,
along
challenges
translating
this
knowledge
into
clinical
interventions.
A
thorough
understanding
biology
crucial
develop
innovative
therapies
improve
treatment
aggressive
resistant
tumors.
