Exploring the biological basis of acupuncture treatment for traumatic brain injury: a review of evidence from animal models DOI Creative Commons
Minmin Wu, Wenjing Song,

Lili Teng

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 7, 2024

Traumatic brain injury (TBI) occurs when external physical forces impact the brain, potentially causing long-term issues such as post-traumatic stress disorders and cognitive dysfunctions. The diverse nature of TBI pathology treatment has led to a rapid acceleration in research on its biological mechanisms over past decade. This surge presents challenges assessing, managing, predicting outcomes for cases. Despite development testing various therapeutic strategies aimed at mitigating neurological decline after TBI, definitive cure these conditions remains elusive. Recently, growing focus been preclinical investigating acupuncture potential method sequelae. Acupuncture, being cost-effective non-pharmacological therapy, demonstrated promise improving functional injury. However, precise underlying anticipated improvements induced by remain poorly understood. In this study, we examined current evidence from animal studies regarding acupuncture’s efficacy post-TBI. We also proposed mechanisms, glial cells (microglia astrocytes), autophagy, apoptosis. information will deepen our understanding through which exerts most beneficial effects post-TBI, assisting forming new clinical maximize benefits patients.

Language: Английский

Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization DOI Creative Commons
Ziwei Lan, Fengbo Tan, Jialin He

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155635 - 155635

Published: April 20, 2024

Cerebral ischemia-reperfusion (I/R) injury often leads to neuronal death through persistent neuroinflammatory responses. Recent research has unveiled a unique inflammatory programmed cell mode known as PANoptosis. However, direct evidence for PANoptosis in ischemic stroke-induced not been established. Although it is widely thought that modulating the balance of microglial phenotypic polarization cerebral I/R could mitigate neuroinflammation-mediated death, remains unknown whether influences PANoptotic triggered by I/R. Our prior study demonstrated curcumin (CUR) preconditioning boost neuroprotective properties olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) intracerebral hemorrhage. Yet, potential capacity curcumin-pretreated OM-MSCs (CUR-OM-MSCs) on reducing during uncertain. To mimic injury, We established vivo models reversible middle artery occlusion (MCAO) C57BL/6 mice and vitro oxygen-glucose deprivation/reoxygenation (OGD/R) HT22 neurons BV2 microglia. findings indicated caused microglia adopt an M1 (pro-inflammatory) phenotype both vitro. Curcumin pretreatment enhanced proliferation anti-inflammatory OM-MSCs. The CUR-OM-MSCs group experienced more pronounced reduction better recovery neurological function than group. Bioinformatic analysis revealed microRNA-423-5p (miRNA-423-5p) expression was obviously upregulated compared treatment induced switch M2 (anti-inflammatory) releasing miRNA-423-5p, which targeted nucleotide-binding oligomerization domain 2 (NOD2), upstream regulator NF-kappaB (NF-κB) Mitogen-Activated Protein Kinase (MAPK) signaling pathways, attenuate resulting from This results provide first demonstration existence conditions. ameliorating effect neuroinflammation mediated via upregulating abundance miRNA-423-5p. intervention effectively alleviates combination with holds promise potentially efficacious stroke future.

Language: Английский

Citations

49
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke DOI Creative Commons

Mingxu Duan,

Ya Xu,

Yuanshu Li

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 18, 2024

Abstract The notion that the central nervous system is an immunologically immune-exempt organ has changed over past two decades, with increasing evidence of strong links and interactions between peripheral immune system, both in healthy state after ischemic hemorrhagic stroke. Although primary injury stroke certainly important, limited therapeutic efficacy, poor neurological prognosis high mortality have led researchers to realize secondary damage may also play important roles influencing long-term neuroinflammatory process one most influences on disease progression. Here, we summarize stroke, particular, how activates recruits components, review recent advances corresponding approaches clinical studies, emphasizing importance role

Language: Английский

Citations

15
Inflammatory Pathogenesis of Post-stroke Depression DOI Creative Commons
Xinyu Feng, Xiaojuan Ma, Juan Li

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Post-stroke depression (PSD) is a complex mood disorder that emerges in individuals following stroke, characterized by the development of depressive symptoms. The pathogensis PSD diverse, with inflammation playing vital role its onset and progression. Emerging evidence suggests microglial activation, astrocyte responses, nuclear factor κB(NF-κB) signaling, dysregulation hypothalamic pituitary adrenal (HPA) axis, alterations brain-derived neurotrophic (BDNF) expression, neurotransmitter imbalances, adenosine triphosphate (ATP) receptors oxidative stress are intricately linked to pathogenesis PSD. involvement inflammatory cytokines these processes highlights significance pathway. Integrating hypotheses, mechanism offers novel perspective expand therapeutic strategies for

Language: Английский

Citations

11
Effects of electroacupuncture on postoperative cognitive dysfunction and its underlying mechanisms: a literature review of rodent studies DOI Creative Commons
Wenbo Zhao, Wei Zou

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: March 26, 2024

With the aging of population, health elderly has become increasingly important. Postoperative cognitive dysfunction (POCD) is a common neurological complication in patients following general anesthesia or surgery. It characterized by decline that may persist for weeks, months, even longer. Electroacupuncture (EA), novel therapy combines physical nerve stimulation with acupuncture treatment from traditional Chinese medicine, holds potential as therapeutic intervention preventing and treating POCD, particularly patients. Although beneficial effects EA on POCD have been explored preclinical clinical studies, reliability limited methodological shortcomings, underlying mechanisms remain largely unexplored. Therefore, we synthesized existing evidence proposed biological neuroinflammation, oxidative stress, autophagy, microbiota-gut-brain axis, epigenetic modification. This review summarizes recent advances provides theoretical foundation, explores molecular prevention offers basis conducting relevant trials.

Language: Английский

Citations

5
Comprehensive analysis of the ischemic stroke burden at global, regional, and national levels (1990–2021): trends, influencing factors, and future projections DOI Creative Commons
Haonan Zhao,

Shaolin Lü,

Jie Yang

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Background and purpose Estimating the global burden of ischemic strokes (IS) is crucial for enhancing prevention control strategies. Methods We collected four epidemiological indicators—prevalence, incidence, deaths, disability-adjusted life years (DALYs)—for stroke from Global Burden Disease (GBD) database, which covers 1990 to 2021. Our research analyzed features IS described trends these indicators. Results The Joinpoint age-period-cohort models reflected changing in age-standardized Decomposition analysis examined factors influencing each indicator. Bayesian Age-Period-Cohort (BAPC) model detailed changes number rate 2021 projected through 2046. Norpred was used verify stability BAPC prediction results. prevalence, DALYs due generally exhibited a downward trend. However, predictions indicated that while incidence decreased 2015, this trend reversed between 2016 expected continue until This reversal likely driven by such as population aging, given age strongly correlated risk factor IS. negatively associated with socio-demographic index (SDI) levels, high systolic blood pressure identified largest deaths. consistency enhances reliability projections. Conclusion Over past two decades, have all declined. projections suggest will show an upward over next decades.

Language: Английский

Citations

0
Comprehensive immune modulation mechanisms of Angong Niuhuang Wan in ischemic stroke: Insights from mass cytometry analysis DOI Creative Commons
Yang Yao, Weihua Ni, Liangshu Feng

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Abstract Background Angong Niuhuang Wan (AGNHW, 安宫牛黄丸), is a classical medicinal formula in Traditional Chinese Medicine (TCM) that has been appreciated for its neuroprotective properties ischemic cerebral injuries, yet intricate mechanisms remain only partially elucidated. Aims This study leverages advanced Mass cytometry (CyTOF) to analyze AGNHW's multifaceted immunomodulation effects in‐depth, emphasizing previously underexplored areas. Results AGNHW mitigated monocyte‐derived macrophages (MoDM) infiltration the brain, distinguishing on those from microglia. While vehicle group exhibited elevated inflammatory markers like CD4, CD8a, and CD44 brains, AGNHW‐treated attenuated their expressions, indicating potential temper post‐ischemic response. Systemically, modulated fundamental immune cell dynamics, notably augmenting CD8 + T cells, B monocytes, neutrophil counts peripheral blood under post‐stroke conditions. Intracellularly, targeted modulation of signaling pathways, revealing remarked inhibition key IκBα, suppression responses brain injuries. Conclusion offers comprehensive portrait stroke, illuminating dual sites action—both systemic—and nuanced cellular molecular dynamics.

Language: Английский

Citations

2
The Aging Immune System: A Critical Attack on Ischemic Stroke DOI

Wenzhe Xu,

Yuying Guo,

Linna Zhao

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

Citations

2
Ischemic Postconditioning Regulates New Cell Death Mechanisms in Stroke: Disulfidptosis DOI Creative Commons

S. Liu,

Qike Wu,

Can Xu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1390 - 1390

Published: Oct. 31, 2024

Stroke poses a critical health issue without effective neuroprotection. We explore ischemic postconditioning's (IPostC) potential to mitigate stroke-induced brain injury, focusing on its interaction with disulfidptosis, novel cell death pathway marked by protein disulfide accumulation. aim clarify IPostC's protective mechanisms against stroke through gene sequencing and experimental analysis in mice.

Language: Английский

Citations

2
Advancing Neurological Health: Insights into Aging, Immunity, and Vascular Dynamics DOI Creative Commons
Tongtong Xu, Jing Ye, Lin Gan

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This editorial provides an overview of recent advancements in the understanding and treatment neurological disorders, focusing on aging, immunity, blood flow, as featured this special issue. The first section explores importance identifying biomarkers aging aging-related diseases, such Alzheimer's Disease, highlighting emerging role saliva-based gut-brain axis disease diagnosis management. In subsequent section, dysregulated immune systems associated with are discussed, emphasizing intricate landscape system during its bidirectional relationship neuroinflammation. Additionally, insights into involvement Myeloid-Derived Suppressor Cells (MDSCs) Multiple Sclerosis (MS) pathogenesis presented. third examines microglia neuroinflammation various including age-related macular degeneration (AMD) Tuberculous Meningitis (TBM). Furthermore, therapeutic potential stem cell extracellular vesicle-based therapies for stroke is explored, along molecular mechanism how inflammation regulates cerebral myocardial ischemia. Finally, flow maintaining vascular health impact disorders novel assessment methods optimizing patient care. Overall, issue offers valuable complex mechanisms underlying identifies avenues intervention.

Language: Английский

Citations

1
Circulating miRNAs modulating systemic low-grade inflammation and affecting neurodegeneration DOI Creative Commons
Sandra Van der Auwera, Sabine Ameling, Katharina Wittfeld

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 135, P. 111130 - 111130

Published: Aug. 28, 2024

Inflammatory processes are an important part of the etiology many chronic diseases across various medical domains, including neurodegeneration. Understanding their regulation on molecular level represents a major challenge. Regulatory microRNAs (miRNAs), have been recognized for role in post-transcriptionally modulating immune-related pathways serving as biomarkers numerous diseases.

Language: Английский

Citations

1