Caveolae with serotonin and NMDA receptors as promising targets for the treatment of Alzheimer’s disease DOI

Moeka Nakashima,

Naoko Suga,

Akari Fukumoto

et al.

International Journal of Physiology Pathophysiology and Pharmacology, Journal Year: 2024, Volume and Issue: 16(5), P. 96 - 110

Published: Jan. 1, 2024

Alzheimer's disease is the most general type of cognitive impairments. Until recently, strategies that prevent its clinical progression have remained more elusive. Consequently, research direction should be for finding effective neuroprotective agents. It has been suggested oxidative stress, mitochondrial injury, and inflammation level might lead to brain cell death in many neurological disorders. Therefore, several autophagy-targeted bioactive compounds may promising candidate therapeutics prevention damage. Interestingly, some risk genes are expressed within cells, which linked cholesterol metabolism, lipid transport, endocytosis, exocytosis and/or caveolae formation, suggesting a fruitful therapeutic target improve This review would highlight latest advances technologies treatment disease. In particular, paradigm serotonin N-methyl-d-aspartate (NMDA) receptors agonist/antagonist structure possibly impairment. cellular membrane biophysics our understanding pathology dysfunction associated with Here, this purpose therapy open potential move care toward disease-modifying certain benefits patients.

Language: Английский

Gut Microbiota Mediates Neuroinflammation in Alzheimer’s Disease: Unraveling Key Factors and Mechanistic Insights DOI
Junyi Liang,

Wang Yueyang,

Bin Liu

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Language: Английский

Citations

5
Tryptophan Metabolism Disorder-Triggered Diseases, Mechanisms, and Therapeutic Strategies: A Scientometric Review DOI Open Access
Xue Chen, Dong Xu, Jie Yu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3380 - 3380

Published: Oct. 4, 2024

Background: Tryptophan is widely present in foods such as peanuts, milk, and bananas, playing a crucial role maintaining metabolic homeostasis health disease. metabolism involved the development progression of immune, nervous, digestive system diseases. Although some excellent reviews on tryptophan exist, there has been no systematic scientometric study yet. Methods: This review provides summarizes research hotspots potential future directions by analyzing annual publications, topics, keywords, highly cited papers sourced from Web Science spanning 1964 to 2022. Results: overview disorder-triggered diseases, mechanisms, therapeutic strategies. Conclusions: The gut microbiota regulates permeability, inflammation, host immunity directly converting indole its derivatives. Gut microbial metabolites regulate activating specific receptors or enzymes. Additionally, kynurenine (KYN) pathway, activated indoleamine-2, 3-dioxygenase (IDO) 2, 3-dioxygenase, affects migration invasion glioma cells COVID-19 depression. IDO inhibitors help improve effectiveness immunotherapy. markers are used for disease therapy, guiding clinical decision-making. serve targets provide new promising strategy neuroprotective/neurotoxic imbalance affecting brain structure function. In summary, this valuable guidance basic application metabolism.

Language: Английский

Citations

5
Psychedelics in neuroinflammation: Mechanisms and therapeutic potential DOI

Júnia L. de Deus,

Juliana Marino Maia, Renato Nery Soriano

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111278 - 111278

Published: Jan. 1, 2025

Language: Английский

Citations

0
Postbiotics as a Therapeutic Tool in Alzheimer's Disease: Insights into Molecular Pathways and Neuroprotective Effects DOI

Garry Hunjan,

Khadga Raj Aran

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102685 - 102685

Published: Feb. 1, 2025

Language: Английский

Citations

0
Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy DOI Creative Commons
Ran Gao, Ya Gao, Wenting Su

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

As the resident macrophages of brain, microglia are crucial immune cells specific to central nervous system (CNS). They constantly surveil their surroundings and trigger immunological reactions, playing a key role in various neurodegenerative diseases (ND). illnesses progress, exhibit multiple phenotypes. Traditionally, have been classified into two main phenotypes upon activation: pro-inflammatory M1 polarization anti-inflammatory M2 polarization. However, this classification is now considered overly simplistic, as it unable fully convey intricacy diversity inflammatory response. Immune regulatory factors, such chemokines secreted by microglia, essential for modulating brain development, maintaining neural milieu, orchestrating responses injury, along with subsequent repair processes. recent years, significance metabolic reprogramming both physiological microglial activity ND has also become increasingly recognized. Upon activation-triggered infection, or ND-microglia typically modify processes transitioning from oxidative phosphorylation (OXPHOS) glycolysis. This shift facilitates rapid energy production but may enhance responses. review seeks summarize function involvement ND.

Language: Английский

Citations

0
Differences in plasma metabolome between non-Hispanic White and non-Hispanic Black women DOI Creative Commons
Ghazaleh Pourali, Liang Li, Myung Sik Jeon

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 13, 2025

Abstract Background To understand potential racial differences in disease susceptibility and develop targeted prevention strategies, it is essential to establish biological between groups healthy individuals. However, knowledge about how race impacts metabolites limited. We therefore performed a cross-sectional study using comprehensive metabolomics analysis investigate among 506 non-Hispanic White (NHW) women 163 Black (NHB) women. Methods untargeted plasma metabolomic profiling Metabolon’s platform (Durham, NC®) identified 1074 9 super-pathways. used multivariable linear regression models, adjusted for confounders, identify associations metabolites. applied Bonferroni correction ( p -value < 10 –5 ) account multiple testing. Results 26 that differed significantly NHW NHB Seven, 10, 17, 23 showed absolute percentage ≥ 50, 40%, 30%, 20%, respectively. Xenobiotics n = 5) amino acids 2) exhibited the largest (≥ 50%) In xenobiotics super-pathway, had higher thymol sulfate, 2-naphthol 2-hydroxyfluorene derived from exposure polycyclic aromatic hydrocarbons, while xanthine acid lysine tryptophan were lower Conclusions report several These findings require validation different could provide insight into investigating may impact burden across diverse populations.

Language: Английский

Citations

0
Neutrophil extracellular traps (NETs) and NETosis in alcohol‐associated diseases: A systematic review DOI Open Access

Mohammed A. S. Khan,

Byoung‐Joon Song, Xin Wang

et al.

Alcohol Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Abstract Heavy alcohol consumption is implicated in the alteration of antimicrobial function neutrophils, such as phagocytosis, chemotaxis, formation neutrophil extracellular traps (NETs), and occurrence NETosis. NETosis an endogenous process elimination invading microbes, autoantibodies, inflammatory elements danger‐associated molecular patterns (DAMPs) pathogen‐associated (PAMPs). However, both exaggeration suppression modulate normal physiological metabolic processes by influencing events at cellular levels. Recent research shows that binge induces NETosis, leading to tissue damage inflammation. Binge consumption, chronic intake, use disorder (AUD) can affect immunity often lead alcohol‐associated liver disease (ALD) and/or other organ damage. Alcohol detrimental consequences multiple organs, including brain, liver, pancreas, gut. Gut‐derived microbial substances, endotoxins circulation, induce systemic Sterile danger signals from damaged cells, cytokines, prostaglandins act proinflammatory stimuli are involved signaling pathways. The alcohol‐induced cytokines chemoattract which interact coordinate with immune cells exaggerate or suppress inflammation within milieu, depending on effects. Several proteins, different receptors, play important roles activation NETs well initiation execution This review article specifically gathers current information its biological components, pathways relating associated ALD AUD multiorgans, We also briefly describe various therapeutic strategies against AUD‐associated experimental models human states.

Language: Английский

Citations

0
Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved DOI Creative Commons
Rui Fan, Yingmin Jia, Zhou Chen

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1080 - 1080

Published: March 21, 2025

Insomnia affects one-third of the world’s population; negative effects insomnia are significant, and traditional medications have numerous side cause considerable suffering. This has aroused interest in obtaining sleep-improving substances from foods. study conducted a comprehensive literature review using Web Science PubMed with keywords like “sleep”, “insomnia”, “food”. A subsequent summary revealed that certain foods, including milk, Ziziphus jujuba, Lactuca sativa, ginseng, Schisandra chinensis, Juglans regia, etc., purported to enhance sleep quality by prolonging duration, reducing latency, alleviating anxiety. The mechanisms these foods’ mainly occur via central nervous system, particularly gamma-aminobutyric acid (GABA)ergic 5-hydroxytryptamine (5-HT)ergic systems. Although this supports fact they potential, further research is needed. There also issues such as more limited fewer mechanisms, pharmacokinetic studies, models being involved. These need be addressed future adequately address problem insomnia. It hoped will contribute into foods properties and, future, provide an effective natural alternative for those seeking medication.

Language: Английский

Citations

0
Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model DOI Creative Commons

Zhihao Xu,

Keqin Liu,

Guoqing Zhang

et al.

Genomics, Journal Year: 2025, Volume and Issue: 117(3), P. 111033 - 111033

Published: March 22, 2025

Language: Английский

Citations

0
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0