Evolution of taste processing shifts dietary preference DOI Creative Commons
Enrico Bertolini, Daniel Münch,

Justine Pascual

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Abstract Food choice is an important driver of speciation and invasion novel ecological niches. However, we know little about the mechanisms leading to changes in dietary preference. Here, use three closely-related species Drosophila sechellia , D. simulans melanogaster study taste circuit food evolution. sechellia, a host specialist, feeds exclusively on single fruit ( Morinda citrifolia noni) - latter two are generalists living various substrates. Using quantitative feeding assays, recapitulate preference for noni detect conserved sweet but altered bitter sensitivity via calcium imaging peripheral neurons. Noni surprisingly activates sensing neurons more strongly due small deletion one gustatory receptor. volumetric ventral brain, show that instead physiology, species-specific processing sugar signals sensorimotor circuits recapitulates differences Our data support receptor alone cannot explain rather modifications how sensory information transformed into motor commands.

Language: Английский

Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster DOI Creative Commons

Bhanu Shrestha,

Jiun Sang, Suman Rimal

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Oct. 2, 2024

Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied date, the attractiveness of oral acids contingent on concentration. Many carboxylic are attractive at ecologically relevant concentrations but become aversive beyond some maximal Recent work found that Drosophila ionotropic receptors IR25a and IR76b expressed sweet-responsive gustatory receptor neurons (GRNs) in labellum, a peripheral organ, mediate feeding behaviors toward dilute acids. Here, we disclose existence pharyngeal sensors melanogaster detect ingested also involved responses These rely IR51b, IR94a, IR94h, together with IR76b, drive We then demonstrate optogenetic activation either Ir94a + or Ir94h GRNs promotes an response, confirming their contributions behavior. Our discovery internal sour taste opens up new avenues for investigating sensation tastants insects.

Language: Английский

Citations

2
Age-dependent switched taste behavior to ribose DOI
Jiun Sang, Youngseok Lee

Insect Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 174, P. 104194 - 104194

Published: Oct. 13, 2024

Language: Английский

Citations

2
Acid and Alkali Taste Sensation DOI Creative Commons
Prakash Pandey, Bhanu Shrestha, Youngseok Lee

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(11), P. 1131 - 1131

Published: Nov. 4, 2023

Living organisms rely on pH levels for a multitude of crucial biological processes, such as the digestion food and facilitation enzymatic reactions. Among these organisms, animals, including insects, possess specialized taste organs that enable them to discern between acidic alkaline substances present in their sources. This ability is vital, compounds directly influences both nutritional value overall health impact ingested substances. In response various chemical properties naturally occurring compounds, insects have evolved peripheral organs. These sensory structures play pivotal role identifying distinguishing nourishing potentially harmful foods. this concise review, we aim provide an in-depth examination molecular mechanisms governing pH-dependent responses, encompassing stimuli, within fruit fly, Drosophila melanogaster, drawing insights from comprehensive analysis existing research articles.

Language: Английский

Citations

4
Fat- and sugar-induced signals regulate sweet and fat taste perception in Drosophila DOI Creative Commons
Yunpo Zhao,

Emilia Johansson,

Jianli Duan

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(11), P. 113387 - 113387

Published: Nov. 1, 2023

In this study, we investigate the interplay between taste perception and macronutrients. While sugar's protein's self-regulation of is known, role fat remains unclear. We reveal that in Drosophila, overconsumption reduces fatty acid favor sweet perception. Conversely, sugar intake increases suppresses taste. Genetic investigations show signal, gut-secreted Hedgehog, enhances Fat induces unpaired 2 (Upd2) secretion from adipose tissue to hemolymph. neurons take up Upd2, which triggers Domeless suppression further downstream JAK/STAT signaling and, via Socs36E, fine-tunes activity Together, our results regulates Hedgehog Upd2 balance nutrient regulate

Language: Английский

Citations

3
A comparison study of pathological features and drug efficacy between Drosophila models of C9orf72 ALS/FTD DOI Open Access
Davin Lee,

Hae Chan Jeong,

Seung Yeol Kim

et al.

Molecules and Cells, Journal Year: 2023, Volume and Issue: 47(1), P. 100005 - 100005

Published: Dec. 22, 2023

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease with complex genetic basis, presenting both in familial and sporadic forms. The hexanucleotide (G

Language: Английский

Citations

2
Pharyngeal neuronal mechanisms governing sour taste perception inDrosophila melanogaster DOI Creative Commons
Bhanu Shrestha, Jiun Sang, Suman Rimal

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied date, the attractiveness of oral acids contingent on concentration. Many carboxylic are attractive at ecologically relevant concentrations but become aversive beyond some maximal Recent work found that Drosophila ionotropic receptors IR25a and IR76b expressed sweet-responsive gustatory receptor neurons (GRNs) in labellum, a peripheral organ, mediate feeding behaviors toward dilute acids. Here, we disclose existence pharyngeal sensors D. melanogaster detect ingested also involved responses These rely IR51b, IR94a, IR94h, together with IR76b, drive We then demonstrate optogenetic activation either Ir94a + or Ir94h GRNs promotes an response, confirming their contributions behavior. Our discovery internal sour taste opens up new avenues for investigating sensation tastants insects.

Language: Английский

Citations

0
Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster DOI Open Access

Bhanu Shrestha,

Jiun Sang, Suman Rimal

et al.

Published: Oct. 2, 2024

Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied date, the attractiveness of oral acids contingent on concentration. Many carboxylic are attractive at ecologically relevant concentrations but become aversive beyond some maximal Recent work found that Drosophila ionotropic receptors IR25a and IR76b expressed sweet-responsive gustatory receptor neurons (GRNs) in labellum, a peripheral organ, mediate feeding behaviors toward dilute acids. Here, we disclose existence pharyngeal sensors D. melanogaster detect ingested also involved responses These rely IR51b, IR94a, IR94h, together with IR76b, drive We then demonstrate optogenetic activation either Ir94a + or Ir94h GRNs promotes an response, confirming their contributions behavior. Our discovery internal sour taste opens up new avenues for investigating sensation tastants insects.

Language: Английский

Citations

0
Drosophila's sensory responses to bacterial peptidoglycan integrates positive and negative signals DOI Open Access
Martina Montanari, Gérard Manière, Ambra Masuzzo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Interactions between animals, including humans, and surrounding microbes are governed by a delicate balance, crucial for survival. Animals must distinguish respond adequately to beneficial harmful maintain homeostasis. Recent research suggests that bacterial components such as lipopolysaccharide peptidoglycan (PGN) influence host behavior modulating neuronal activity. PGN detection specific neurons can prompt infected female flies reduce oviposition or trigger avoidance behaviors via gustatory neurons. Using behavioral assays calcium imaging, we found PGNs also act attractants, activating the sweet taste circuit in concentration-dependent manner. Our findings demonstrate integrate PGN-derived positive negative signals make ad hoc decisions. This dual response underlines need Drosophila different concentrations of compounds their environment, integrating sensory data navigate efficiently microbe-co-inhabited environments. Highlights - Bacterial is attractive at high Gr5a activated an NF-kB independent manner PER remains axenic Fly integrates both aversive

Language: Английский

Citations

0
Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster DOI Creative Commons
Bhanu Shrestha, Jiun Sang, Suman Rimal

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Dec. 11, 2024

Sour taste, which is elicited by low pH, may serve to help animals distinguish appetitive from potentially harmful food sources. In all species studied date, the attractiveness of oral acids contingent on concentration. Many carboxylic are attractive at ecologically relevant concentrations but become aversive beyond some maximal Recent work found that Drosophila ionotropic receptors IR25a and IR76b expressed sweet-responsive gustatory receptor neurons (GRNs) in labellum, a peripheral organ, mediate feeding behaviors toward dilute acids. Here, we disclose existence pharyngeal sensors melanogaster detect ingested also involved responses These rely IR51b, IR94a, IR94h, together with IR76b, drive We then demonstrate optogenetic activation either Ir94a + or Ir94h GRNs promotes an response, confirming their contributions behavior. Our discovery internal sour taste opens up new avenues for investigating sensation tastants insects.

Language: Английский

Citations

0
Evolution of taste processing shifts dietary preference DOI Creative Commons
Enrico Bertolini, Daniel Münch,

Justine Pascual

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Abstract Food choice is an important driver of speciation and invasion novel ecological niches. However, we know little about the mechanisms leading to changes in dietary preference. Here, use three closely-related species Drosophila sechellia , D. simulans melanogaster study taste circuit food evolution. sechellia, a host specialist, feeds exclusively on single fruit ( Morinda citrifolia noni) - latter two are generalists living various substrates. Using quantitative feeding assays, recapitulate preference for noni detect conserved sweet but altered bitter sensitivity via calcium imaging peripheral neurons. Noni surprisingly activates sensing neurons more strongly due small deletion one gustatory receptor. volumetric ventral brain, show that instead physiology, species-specific processing sugar signals sensorimotor circuits recapitulates differences Our data support receptor alone cannot explain rather modifications how sensory information transformed into motor commands.

Language: Английский

Citations

0