Cholesterol taste avoidance in Drosophila melanogaster DOI Creative Commons
Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee

et al.

eLife, Journal Year: 2025, Volume and Issue: 14

Published: April 17, 2025

The question as to whether animals taste cholesterol is not resolved. This study investigates the fruit fly, Drosophila melanogaster , capable of detecting through their gustatory system. We found that flies are indifferent low levels and avoid higher levels. avoidance mediated by receptor neurons (GRNs), demonstrating can cholesterol. cholesterol-responsive GRNs comprise a subset also responds bitter substances. Cholesterol detection depends on five ionotropic (IR) family members, disrupting any these genes impairs flies' ability Ectopic expressions IRs in reveals two classes receptors, each with three shared one unique subunit. Additionally, expressing receptors sugar-responsive confers attraction cholesterol, GRNs.

Language: Английский

Avoiding alkaline taste through ionotropic receptors DOI Creative Commons
Prakash Pandey,

Bhanu Shrestha,

Youngseok Lee

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 110087 - 110087

Published: May 23, 2024

Taste organs contain distinct gustatory receptors that help organisms differentiate between nourishing and potentially harmful foods. The detection of high pH levels plays a crucial role in food selection, but the specific responsible for perceiving elevated foods have remained unknown. By using

Language: Английский

Citations

7
Cholesterol taste avoidance in Drosophila melanogaster DOI Open Access
Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee

et al.

Published: April 7, 2025

The question as to whether animals taste cholesterol is not resolved. This study investigates the fruit fly, Drosophila melanogaster , capable of detecting through their gustatory system. We found that flies are indifferent low levels and avoid higher levels. avoidance mediated by receptor neurons (GRNs), demonstrating can cholesterol. responsive GRNs comprise a subset also respond bitter substances. Cholesterol detection depends on five ionotropic (IR) family members, disrupting any these genes impairs flies’ ability Ectopic expressions IRs in reveals two classes receptors, each with three shared one unique subunit. Additionally, expressing receptors sugar-responsive confers attraction cholesterol, GRNs.

Language: Английский

Citations

0
Cholesterol taste avoidance in Drosophila melanogaster DOI Open Access
Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee

et al.

Published: April 7, 2025

The question as to whether animals taste cholesterol is not resolved. This study investigates the fruit fly, Drosophila melanogaster, capable of detecting through their gustatory system. We found that flies are indifferent low levels and avoid higher levels. avoidance mediated by receptor neurons (GRNs), demonstrating can cholesterol. cholesterol-responsive GRNs comprise a subset also responds bitter substances. Cholesterol detection depends on five ionotropic (IR) family members, disrupting any these genes impairs flies' ability Ectopic expressions IRs in reveals two classes receptors, each with three shared one unique subunit. Additionally, expressing receptors sugar-responsive confers attraction cholesterol, GRNs.

Language: Английский

Citations

0
Cholesterol taste avoidance in Drosophila melanogaster DOI Creative Commons
Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee

et al.

eLife, Journal Year: 2025, Volume and Issue: 14

Published: April 17, 2025

The question as to whether animals taste cholesterol is not resolved. This study investigates the fruit fly, Drosophila melanogaster , capable of detecting through their gustatory system. We found that flies are indifferent low levels and avoid higher levels. avoidance mediated by receptor neurons (GRNs), demonstrating can cholesterol. cholesterol-responsive GRNs comprise a subset also responds bitter substances. Cholesterol detection depends on five ionotropic (IR) family members, disrupting any these genes impairs flies' ability Ectopic expressions IRs in reveals two classes receptors, each with three shared one unique subunit. Additionally, expressing receptors sugar-responsive confers attraction cholesterol, GRNs.

Language: Английский

Citations

0