Regulatory roles of miRNA-530 in the post-transcriptional regulation of NF-κB signaling pathway through targeted modulation of IκBα in Sebastes schlegelii DOI
Ning Ning Wang,

Yize Song,

Yan Xu

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 149, P. 109604 - 109604

Published: May 5, 2024

Language: Английский

Cloning of Camellia sinensis MLO1 gene and analysis of disease resistance of miRNA as green pesticide DOI
Xin Jing, Yichen Zhao

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2025, Volume and Issue: 161(1)

Published: March 25, 2025

Language: Английский

Citations

0
MicroRNA-770 promotes polarization of macrophages and hemorrhoids by suppressing RYBP expression and monoubiquitination of histone H2A on Lys119 modification DOI
Haikun Zhou, Te Liu, Silin Zhong

et al.

Molecular Immunology, Journal Year: 2025, Volume and Issue: 182, P. 41 - 53

Published: April 4, 2025

Language: Английский

Citations

0
Epigenetics factors in schizophrenia: future directions for etiologic and therapeutic study approaches DOI Creative Commons
Haidong Yang, Wenxi Sun, Jin Li

et al.

Annals of General Psychiatry, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 4, 2025

Schizophrenia is a complex, heterogeneous, and highly disabling severe mental disorder whose pathogenesis has not yet been fully elucidated. Epigenetics, as bridge between genetic environmental factors, plays an important role in the pathophysiology of schizophrenia. Over past decade, epigenetic-wide association studies have rapidly become branch psychiatric research, especially deciphering molecular mechanisms This review systematically analyzes recent advances epigenome-wide (EWAS) schizophrenia, focusing on technological developments. We synthesize findings from large-scale EWAS alongside emerging evidence DNA methylation patterns, histone modifications, regulatory networks, emphasizing their roles disease treatment responses. In addition, this provides prospective outlook, evaluating impact that developments may future With continuous advancement high-throughput sequencing technology increasing maturity big data analysis methods, epigenetics expected to significant early diagnosis, prognosis assessment even personalized

Language: Английский

Citations

0
Recent advances in investigation of circRNA/lncRNA-miRNA-mRNA networks through RNA sequencing data analysis DOI Creative Commons

Yulan Gao,

Konii Takenaka,

Si-Mei Xu

et al.

Briefings in Functional Genomics, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Abstract Non-coding RNAs (ncRNAs) are RNA molecules that transcribed from DNA but not translated into proteins. Studies over the past decades have revealed ncRNAs can be classified small RNAs, long non-coding and circular by genomic size structure. Accumulated evidences eludicated critical roles of these transcripts in regulating gene expression through transcription translation, thereby shaping cellular function disease pathogenesis. Notably, recent studies investigated as competitive endogenous (ceRNAs) sequester miRNAs modulate mRNAs expression. The ceRNAs network emerges a pivotal regulatory function, with significant implications various diseases such cancer neurodegenerative disease. Therefore, we highlighted multiple bioinformatics tools databases aim to predict interaction. Furthermore, discussed limitations using current technologies potential improvement for detection. Understanding dynamic interplay within may advance biological comprehension, well providing targets therapeutic intervention.

Language: Английский

Citations

0
miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression DOI Creative Commons
Chen Wang, Runxi Fu, Yunkun Wang

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(6), P. 941 - 954

Published: March 19, 2024

Abstract Medulloblastoma (MB), a prevalent pediatric central nervous system tumor, is influenced by microRNAs (miRNAs) that impact tumor initiation and progression. However, the specific involvement of miRNAs in MB tumorigenesis remains unclear. Using single-cell RNA sequencing, we identified ROR2 expression normal human fetal cerebellum. Subsequent analyses, including immunofluorescence, quantitative real-time PCR (qRT-PCR), Western blot, assessed tissues cell lines. We investigated miR-124-3p miR-194-5p their regulatory role through dual-luciferase reporter, qRT-PCR, western blot assays. Mechanistic insights were gained functional assays exploring miR-124-3p, miR-194-5p, on growth vitro vivo. observed significantly reduced elevated High inversely correlated with overall survival WNT SHH subgroups patients. Functionally, overexpressing inhibiting suppressed malignant transformation vivo tumorigenicity. Mechanistically, synergistically regulated ROR2/PI3K/Akt pathway, influencing Our findings indicate function as suppressors, progression via axis, suggesting key mechanism therapeutic targets for

Language: Английский

Citations

3
DNMT1 driven by mouse amniotic fluid mesenchymal stem cell exosomes improved corneal cryoinjury via inducing microRNA-33 promoter DNA hypermethylation modification in corneal epithelium cells DOI
Weiqi Xu,

Xinfeng Fei,

Zeyu Cui

et al.

Human Cell, Journal Year: 2024, Volume and Issue: 37(4), P. 1091 - 1106

Published: May 23, 2024

Language: Английский

Citations

2
METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a DOI Creative Commons

Dengyun Gao,

Jian Shi,

Siyu Lu

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 6, 2024

Osteomyelitis (OM) is an inflammatory disease of bone infection and destruction characterized by dysregulation homeostasis. Staphylococcus aureus (SA) has been reported to be the most common pathogen causing infectious OM. Recent studies have demonstrated that N6-methyladenosine (m6A) regulators are associated with development However, molecular mechanism m6A modifications in OM remains unclear. Here, we investigated function methyltransferase-like 3 (METTL3)-mediated modification development. In this study, human mesenchymal stem cells (hBMSCs) were treated staphylococcal protein A (SpA), a vital virulence factor SA, construct cell models Firstly, found METTL3 was upregulated patients SpA-induced hBMSCs, SpA treatment suppressed osteogenic differentiation induced oxidative stress injury hBMSCs. Functional experiments showed knockdown alleviated inhibition promotion inflammation SpA-treated Furthermore, METTL3-mediated miR-320a expression promoting pri-miR-320a maturation, mitigating effects on SpA-mediated differentiation, responses can reversed miR-320 mimic. addition, phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) downstream target miR-320a, upregulation PIK3CA miR-320a-induced during infection. Finally, silencing regulating miR-320a/PIK3CA axis. Taken together, our data METTL3/m6A/miR-320a/PIK3CA axis regulated stress, OM, which may provide new therapeutic strategy for patients.

Language: Английский

Citations

2
The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma DOI
Zhiyi Wang, Zhenyuan Gao, Yifei Yang

et al.

Bone, Journal Year: 2024, Volume and Issue: unknown, P. 117333 - 117333

Published: Nov. 1, 2024

Language: Английский

Citations

2
MiR-103-5p deficiency suppresses lipid accumulation via upregulating PLSCR4 and its host gene PANK3 in goat mammary epithelial cells DOI
Lu Zhu,

Hongyun Jiao,

Wenchang Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131240 - 131240

Published: April 5, 2024

Language: Английский

Citations

1
Regulatory RNA: from molecular insights to therapeutic frontiers DOI Creative Commons
Tae Soo Kim, Tae-Kyung Kim

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(6), P. 1233 - 1234

Published: June 14, 2024

Language: Английский

Citations

1