Postbiotics of Naturally Fermented Synbiotic Mixture of Rice Water Aids in Promoting Colonocyte Health

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 344 - 344

Published: March 13, 2024

The eubiotic state of the gut microbiota is primarily brought about by various probiotic species that colonize gut. It becoming very clear probiotic-metabolite mixtures in luminal milieu central establishing cross-kingdom signalling networks to maintain gut-multi-organ axes health. Culturally, different fermented foods and beverages have been regional staples since ancient times, are known be enriched with probiotics. However, variations including environment, staple food source (prebiotics), fermentation methods, among other factors, influence fermenting species. Fermented rice water (FRW), an economical, easy make, simple beverage a rich synbiotics. Therefore, consumption allows for intake variety region-specific live secondary metabolites (postbiotics) present such symbiotic may also contribute toward maintaining normal intestinal cellular functions. In this study, we highlight as consumed their form hold promise alleviating gut-related diseases. Our results show overnight cooked edible enables growth bacterial belonging Lactic Acid Bacteria group (Leuconostoc lactis, Weisella confusa, cibacria, Lactococcus lactococcus taiwanensis, Lactobacillus fermentum, nagelii, delbrueckii ssp. indicus). Metabolomic analysis over two-nights identified more than 200 postbiotic metabolites. postbiotics contributing energy metabolism, gut-multiorgan axes, microbial paraprobiotics (~10 h) compared water. Functional via gene expression studies nutrient absorption (mct-1 mct-2) barrier integrity (occludin zo-1) reveals significant upregulation these genes upon FRW treatment HT29 colon cells. This study first-of-its-kind demonstrate proof-of-principle naturally positively modulates colonocyte

Language: Английский

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Cardiac energy metabolic disorder and gut microbiota imbalance: a study on the therapeutic potential of Shenfu Injection in rats with heart failure

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

To investigate the relationship between heart failure (HF) and gut microbiota-mediated energy metabolism, to explore role of Shenfu Injection in this process. In study, Adriamycin-induced chronic (CHF) rat model was used randomly divided into blank control group (Normal, n = 9), HF (Model, 12), treatment (SFI, positive drug (TMZ, 9). The changes microbiota structure were analyzed by 16S rRNA high-throughput sequencing, content short-chain fatty acids (SCFAs) detected targeted metabolomics technology, cardiac function metabolism-related indicators evaluated. Myocardial metabolism rats disordered, characterized reduced acid oxidation, enhanced anaerobic glycolysis glucose, mitochondrial damage, decreased ATP content; imbalanced, with a reduction beneficial bacteria, an increase conditional pathogenic impaired intestinal barrier function; Both trimetazidine improved myocardial function, but more significant regulating improving health; production SCFAs from increased, which may be closely related metabolism; SCFAs-producing bacteria Akkermansia Blautia played key development HF, their abundance positively correlated content. treating improve health microbiota, especially Blautia, thereby exerting therapeutic effects. This provides theoretical support for strategies based on microbiota.

Language: Английский

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High Altitude Microbiome: Insight into Yak Gut Microbiota and its Nutritional and Functional Involvement for Food Systems

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104897 - 104897

Published: Feb. 1, 2025

Language: Английский

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Atypical gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice

Cell Reports, Journal Year: 2025, Volume and Issue: unknown, P. 115448 - 115448

Published: March 1, 2025

Language: Английский

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Role and Mechanism of Short-Chain Fatty Acids in Skeletal Muscle Homeostasis and Exercise Performance

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1463 - 1463

Published: April 26, 2025

Acetate, propionate, and butyrate are major short-chain fatty acids (SCFAs) produced by the gut microbiota as key metabolic byproducts. These SCFAs influence skeletal muscle homeostasis exercise performance through various mechanisms. This review explores current knowledge on mechanisms which mass, strength, metabolism, inflammation. Acetate enhances mitochondrial function glucose while supports mass preservation suppressing inflammation autophagy. Propionate plays complex roles, aiding regulation, but potentially impairing myogenic differentiation at high concentrations. modulate insulin sensitivity oxidative stress; their interactions with host energy systems immunity significantly health. Although therapeutic potential is evident, further studies, especially human clinical trials, necessary to validate effective applications. synthesizes emerging evidence outlines specific future research priorities.

Language: Английский

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The Improvement and Related Mechanism of Microecologics on the Sports Performance and Post-Exercise Recovery of Athletes: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1602 - 1602

Published: May 24, 2024

The diversity and functionality of gut microbiota may play a crucial role in the function human motor-related systems. In addition to traditional nutritional supplements, there is growing interest microecologics due their potential enhance sports performance facilitate post-exercise recovery by modulating microecological environment. However, lack relevant reviews on this topic. This review provides comprehensive overview studies investigating effects various types microecologics, such as probiotics, prebiotics, synbiotics, postbiotics, enhancing facilitating regulating energy metabolism, mitigating oxidative-stress-induced damage, immune responses, attenuating bone loss. Although further investigations are warranted elucidate underlying mechanisms through which exert effects. summary, study aims provide scientific evidence for future development athletics.

Language: Английский

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Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice

Metabolism Open, Journal Year: 2024, Volume and Issue: 24, P. 100326 - 100326

Published: Oct. 23, 2024

Language: Английский

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β cell acetate production and release are negligible

Islets, Journal Year: 2024, Volume and Issue: 16(1)

Published: April 12, 2024

Background Studies suggest that short chain fatty acids (SCFAs), which are primarily produced from fermentation of fiber, regulate insulin secretion through free acid receptors 2 and 3 (FFA2 FFA3). As these G-protein coupled (GPCRs), they have potential therapeutic value as targets for treating type diabetes (T2D). The exact mechanism by other aspects pancreatic β cell function is unclear. It has been reported glucose-dependent release acetate cells negatively regulates glucose stimulated secretion. While data raise the possibility acetate's autocrine action on receptors, findings not independently confirmed, multiple concerns exist with this observation, particularly lack specificity precision detection methodology used.

Language: Английский

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Study on the physicochemical properties and immune regulatory mechanism of polysaccharide fraction from Aronia Melanocarpa fruit

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137696 - 137696

Published: Nov. 16, 2024

Language: Английский

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Jingfang Granules alleviates the lipid peroxidation induced ferroptosis in rheumatoid arthritis rats by regulating gut microbiota and metabolism of short chain fatty acids

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119160 - 119160

Published: Nov. 1, 2024

Language: Английский

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