Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(11), P. 2745 - 2755
Published: May 11, 2024
Language: Английский
BMC Nephrology, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 8, 2025
The effects of acute kidney injury (AKI) on liver-related outcomes in patients with hepatitis B virus (HBV) infection remain unclear. study aimed to evaluate the association between AKI mortality and complications HBV infection. multicenter, retrospective cohort included Chinese adults from 24 regional central hospitals January 2000 December 2022. was defined as a ≥ 26.5 μmol/l increase serum creatinine concentration within 48 h, or 50% over baseline 7 days. primary outcome post-discharge mortality, while secondary composite new-onset liver cirrhosis hepatocellular carcinoma. Cox proportional hazard model employed for analyses. Of 86,204 inpatients without cancer at baseline, 4407(5.1%) experienced AKI. During mean follow-up 4.6 ± 2.4 years, 334 (0.4%) died events. After adjustment, during hospitalization significantly associated higher risk after discharge (adjusted ratio (HR), 1.78; 95% confidence intervals (CI), 1.26–2.51, P = 0.001), especially those severe Similarly, carcinoma HR, 1.33; 95%CI, 1.10–1.60, 0.004). remained consistent across different subgroups. substantial increased incident complication. Our findings highlight importance monitoring tailoring personalized treatments.
Language: Английский
Citations
2
Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(6), P. 2069 - 2081
Published: Feb. 26, 2024
Abstract Aim We aimed to determine the macrovascular and microvascular outcomes of intensive versus standard glucose‐lowering strategies in type 2 diabetes (T2D) investigate relationships between these trial arm glycated haemoglobin (HbA1c) reduction. Materials Methods In this systematic review meta‐analysis, we identified relevant trials from MEDLINE, Embase, Cochrane Library, bibliographies up August 2023. Macrovascular outcomes, along with safety were evaluated. Pooled study‐specific hazard ratios (HRs) 95% confidence intervals (CIs) calculated, meta‐regression was employed analyse HbA1c Results included 11 unique RCTs involving 51 469 patients T2D (intensive therapy, N = 26 691; 24 778). Intensive therapy reduced risk non‐fatal myocardial infarction (MI) (HR 0.84; CI 0.75‐0.94) no difference major adverse cardiovascular events 0.97; 0.92‐1.03) other outcomes. retinopathy 0.85; 0.78‐0.93), nephropathy 0.71; 0.58‐0.87) composite 0.88; 0.77‐1.00). Meta‐regression analyses showed modest evidence inverse linear reduction events, MI, stroke retinopathy, but not statistically significant. Conclusions people T2D, glucose control associated a MI several particularly nephropathy. The lack an effect on most calls for more comprehensive approach managing factors alongside glycaemic control.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1683 - 1683
Published: Feb. 16, 2025
High-density lipoprotein (HDL) exhibits multiple metabolic protective functions, such as facilitating cellular cholesterol efflux, antioxidant, anti-inflammatory, anti-apoptotic and anti-thrombotic properties, showing antidiabetic renoprotective potential. Diabetic kidney disease (DKD) is considered to be associated with high-density (HDL-C). The hyperglycemic environment, non-enzymatic glycosylation, carbamylation, oxidative stress systemic inflammation can cause changes in the quantity quality of HDL, resulting reduced HDL levels abnormal function. Dysfunctional also have a negative impact on pancreatic β cells cells, leading progression DKD. Based these findings, new HDL-related DKD risk predictors gradually been proposed. Interventions aiming improve function, infusion recombinant (rHDL) or lipid-poor apolipoprotein A-I (apoA-I), significantly glycemic control show renal effects. However, recent studies revealed U-shaped relationship between HDL-C DKD, loss properties high may related composition deposition dysfunctional particles that exacerbate damage. Further research needed fully elucidate complex role Given important health, developing HDL-based therapies augment rather than simply increasing its level, critical step managing development
Language: Английский
Citations
1
Annals of Internal Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 28, 2024
Rosuvastatin and atorvastatin are the most widely prescribed moderate- to high-intensity statins. However, evidence on their efficacy safety during actual use is limited.
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 23, 2024
There is no reliable causal evidence for the effect of statins on diabetic nephropathy (DN) and retinopathy (DR), results previous observational studies are contradictory. Genetic variants linked to low-density lipoprotein cholesterol (LDL-C) from a UK biobank genome-wide association study located within 100kb window around HMGCR were used proxy statins, comparing with PCSK9 inhibitors (control). DN DR summary statistics obtained FinnGen study. Secondary MR analyses NHANES cross-sectional data validation. Drug-target Mendelian randomization (MR) was applied investigate between genetically proxied inhibition DR, p < 0.0125 considered significant after Bonferroni Correction. To triangulate findings, genetic whole blood-derived targets gene expression (cis-eQTL) plasma-derived protein (cis-pQTL) levels perform secondary National Health Nutrition Examination Survey analysis. Genetically associated higher risks (DN: OR = 1.79, 0.01; DR: 1.41, 0.004), while such found PCSK9. confirmed these associations. Cross-sectional analysis revealed positive link statin use incidence (OR 1.26, 0.03) negative glomerular filtration rate (Beta − 1.9, 0.03). This provides that increased DN/DR, this may not be attributed their LDL-C-lowering properties. For patients dyslipidemia, preferable alternative.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 3, 2024
Disorders of lipid metabolism play a key role in the initiation and progression chronic kidney disease (CKD). Recently, research on CKD has rapidly increased worldwide. However, comprehensive bibliometric analyses this field are lacking. Therefore, study aimed to evaluate publications over past 20 years based analysis methods understand important achievements, popular topics, emerging thematic trends.
Language: Английский
Citations
4
Journal of Diabetes Research, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Background: It remains unclear whether cholesterol-lowering therapy can reduce the incidence of microvascular complications in patients with diabetes. We aim to explore potential causal relationship between three common types drugs and diabetic through drug-target Mendelian randomization (MR) study, laying groundwork for development new medications. Methods: In this we collected single nucleotide polymorphisms (SNPs) associated HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) inhibitors, PCSK9 (proprotein convertase subtilisin/kexin type 9) NPC1L1 (Niemann-Pick C1-Like 1) inhibitors from published genome-wide association study statistics. Subsequently, MR analyses were performed investigate effects these on low-density lipoprotein cholesterol (LDL-C) level-mediated diabetes mellitus. Coronary atherosclerosis as a positive control. Primary outcomes included nephropathy, retinopathy, neuropathy FinnGen Consortium. Results: The analysis revealed significant associations inhibition increased risks nephropathy (OR [95%confidence interval (CI)] = 1.88 [1.50, 2.36], p 5.55 × 10-8), retinopathy [95%CI] 1.86 [1.54, 2.24], 6.28 10-11), 2.63 [1.84, 3.75], 1.14 10-7) using inverse variance weighted method. have been an risk 1.30 [1.07, 1.58], 0.009) 1.40 [1.15, 1.72], 0.001); significantly 0.48 [0.28, 0.85], 0.01). coronary heart disease Conclusions: findings show that may increase complications. However, provide protection against retinopathy.
Language: Английский
Citations
0
The Lancet Regional Health - Western Pacific, Journal Year: 2025, Volume and Issue: 54, P. 101275 - 101275
Published: Jan. 1, 2025
Early diagnosis of chronic kidney disease (CKD) is crucial for timely intervention to delay progression and improve patient outcomes. However, data clinical characteristics Chinese patients with undiagnosed, early-stage CKD are lacking. REVEAL-CKD a multinational, observational study using real-world in selected countries describe factors associated undiagnosed stage 3 CKD, time diagnosis, management post diagnosis. We analysed from 20 hospitals the China Renal Data System. Adult two consecutive estimated glomerular filtration rate (eGFR) measurements indicating (30-<60 ml/min/1.73 m2) recorded >90-730 days apart 2015 2020 were eligible. Among 35,222 eligible patients, 25,214 (71.6%) (lacked diagnostic code before up six months post-second-qualifying-eGFR). Only 2344 (9.3%) eventually received delayed whose median was 18.1 (95% CI: 17.6-18.8) months. Age ≥65 years, being female, 3A absence nephrology visit comorbidities (diabetes, established cardiovascular disease, heart failure, hypertension, or nephritic syndrome) (P < 0.001). diagnosed proportion receiving ≥1 prescription guideline-recommended medications (e.g. renin-angiotensin system inhibitors) increased their eGFR decline attenuated post-diagnosis. The high concerning. improved patterns attenuation post-diagnosis demonstrate importance early patients. AstraZeneca China.
Language: Английский
Citations
0
Clinical Kidney Journal, Journal Year: 2025, Volume and Issue: 18(4)
Published: March 12, 2025
Cardiovascular-kidney-metabolic (CKM) syndrome affects a significant portion of the general population. Urinary albumin-to-creatinine ratio (UACR) is an important indicator kidney injury. While some studies have indicated associations between UACR within normal range and mortality outcomes, it remains uncertain whether traditionally could help to distinguish prognosis CKM patients. This cohort study included patients with at stages 2 3 from China Renal Data System (CRDS) UK Biobank (UKB) databases. was treated as continuous variable categorized into low-normal high-normal. The were initially assessed in CRDS database subsequently validated UKB database. Multivariable Cox proportional hazards regression employed estimate UACR. Additionally, subgroup analyses sensitivity conducted enhance robustness results. encompassed total 14 602 82 694 Near-linear identified levels progression stage 4, well all-cause mortality. When compared group, individuals high-normal exhibited elevated risk 4 (HR 1.133, 95% CI 1.026-1.250) increased 2.321, 1.679-3.208) These further corroborated Consistent findings also observed through analyses. indicate that are significantly associated poor among 3. results underscore critical role identifying high-risk populations, particularly metabolic disorders. information may prove valuable for monitoring implementing intervention strategies
Language: Английский
Citations
0
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: April 27, 2025
Evidence regarding the causal relationship between lipid-lowering drugs and cystic kidney disease, including polycystic disease (PKD), was limited. This study aimed to evaluate lipid phenotypes mediated by drug targets-3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR), proprotein convertase subtilisin/kexin type-9 (PCSK9), Niemann-Pick C1-like 1 (NPC1L1)-and risk of PKD. Genetic variants encoding targets-HMGCR, PCSK9, NPC1L1-from published genome-wide association (GWAS) statistics were collected perform target Mendelian randomization (MR) analysis. Summary for GWAS PKD obtained from FinnGen consortium European Bioinformatics Institute. Inverse variance weighting (IVW) used as primary MR analysis method, with sensitivity analyses conducted ensure robustness results. Increased gene expression HMGCR associated an elevated (IVW-MR: odds ratio [OR] = 3.05, 95% confidence interval [CI] 1.19-7.84, p 0.02) OR 2.13, CI 1.01-4.46; 0.045). There no evidence effects PCSK9 NPC1L1 targets on Cochran's Q test, MR-PRESSO, MR-Egger intercept tests showed heterogeneity or horizontal pleiotropy among instrumental variables. supported that increased PKD, suggesting potential benefits statin therapy Further research is necessary elucidate specific mechanisms therapeutic applications inhibitors.
Language: Английский
Citations
0