The Synergistic Effect on the Mimetic Optical Structure of Feline Eyes toward Household Health Monitoring of Acute and Chronic Diseases DOI
Shan Zhang, Guanglin Zhang, Guqiao Ding

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 4944 - 4956

Published: Feb. 1, 2024

A breakthrough in the performance of bionic optical structures will only be achieved if we can obtain an in-depth understanding synergy mechanisms operating natural and find ways to imitate them. In this work, inspired by feline eyes, substrate that takes advantage a synergistic effect occurs between resonant reflective was designed. The components leads Raman enhancement factor (EF) 1.16 × 107, which is much greater than using reflective/resonant cavities on their own. Finite-difference time-domain (FDTD) simulations experimental results together confirm mechanism realizing multiple reflections repeated absorptions light, generating strong local electric field. Thus, 2–3 order magnitude increase sensitivity could achieved. More importantly, with homemade centrifugal device, above substrates were further used develop rapidly highly sensitive household health monitoring system (detection time <3 min). It thus give early warning acute diseases high risk (e.g., myocardial infarction (AMI) cerebral peduncle). Due good reusability storability (9% 8% reduction EF after washing 30 times 9 months storage, respectively) substrates, reduce detection costs (to ∼$1), making them cheaper use current gold-standard methods ∼$16 for gout detection).

Language: Английский

Novel portable photoelectrochemical sensor based on CdS/Au/TiO2 nanotube arrays for sensitive, non-invasive, and instantaneous uric acid detection in saliva DOI
Xiaolong Ma,

Lijun Deng,

Ziwei Zou

et al.

Talanta, Journal Year: 2024, Volume and Issue: 271, P. 125646 - 125646

Published: Jan. 7, 2024

Language: Английский

Citations

18
Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential DOI Open Access
Arrigo F.G. Cicero, Federica Fogacci, Valentina Di Micoli

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7027 - 7027

Published: April 10, 2023

Purines, such as adenine and guanine, perform several important functions in the cell. They are found nucleic acids; structural components of some coenzymes, including NADH coenzyme A; have a crucial role modulation energy metabolism signal transduction. Moreover, purines been shown to play an physiology platelets, muscles, neurotransmission. All cells require balanced number for growth, proliferation, survival. Under physiological conditions, enzymes involved maintain ratio between their synthesis degradation In humans, final product purine catabolism is uric acid, while most other mammals possess enzyme uricase that converts acid allantoin, which can be easily eliminated with urine. During last decades, hyperuricemia has associated human extra-articular diseases (in particular, cardiovascular ones) clinical severity. this review, we go through methods investigation dysfunctions, looking at functionality xanthine oxidoreductase formation catabolites urine saliva. Finally, discuss how these molecules used markers oxidative stress.

Language: Английский

Citations

41
Progress in optical sensors-based uric acid detection DOI Open Access

Chiyu Ma,

Nan Jiang, Xianyou Sun

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 237, P. 115495 - 115495

Published: July 3, 2023

Language: Английский

Citations

41
Pyrene Derivative Incorporated Ni MOF as an Enzyme Mimic for Noninvasive Salivary Glucose Detection Toward Diagnosis of Diabetes Mellitus DOI
Mallikarjuna Swamy Shabanur Matada,

Guru Prasad Kuppuswamy,

Sheethal Sasi

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(14), P. 17219 - 17231

Published: April 2, 2024

Herein, we demonstrate the detection of glucose in a noninvasive and nonenzymatic manner by utilizing an extended gate field-effect transistor (EGFET) based on organic molecule pyrene phosphonic acid (PyP4OH8) incorporated nickel metal–organic framework (NiOM-MOF). The prepared electrode responds selectively to instead sucrose, fructose, maltose, ascorbic acid, uric 1× phosphate buffer saline solution. Also, scanning Kelvin probe system, sensing electrode's work function (Φ) is measured validate glucose-sensing mechanism. sensitivity, range, response time, limit detection, quantification are determined be 24.5 μA mM–1 cm–2, 20 μM 10 mM, less than 5 s, 2.73 μM, 8.27 respectively. Most interestingly, developed follows Michaelis–Menten kinetics, calculated rate constant (km) 0.07 mM indicates higher affinity NiOM-MOF toward glucose. real-time analysis has revealed that sensitive detect real human saliva, it can alternative device for Overall, outcomes EGFET studies electrodes well-suited expeditious levels saliva.

Language: Английский

Citations

11
A point-of-care, label-free OECT sensor for uric acid detection: validation in human saliva DOI Creative Commons

Francesca Ceccardi,

Federica Mariani, Francesco Decataldo

et al.

Electrochimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 145834 - 145834

Published: Feb. 1, 2025

Language: Английский

Citations

1
A non-enzymatic electrochemical sensor composed of nano-berry shaped cobalt oxide nanostructures on a glassy carbon electrode for uric acid detection DOI
Vandana Nagal,

Talia Tuba,

Virendra Kumar

et al.

New Journal of Chemistry, Journal Year: 2022, Volume and Issue: 46(25), P. 12333 - 12341

Published: Jan. 1, 2022

Non-enzymatic electrochemical uric acid sensor fabrication with excellent performance using nano-berry shaped cobalt oxide nanostructures on a glassy carbon electrode.

Language: Английский

Citations

38
Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules) DOI

Harshita,

Hui‐Fen Wu, Suresh Kumar Kailasa

et al.

Luminescence, Journal Year: 2022, Volume and Issue: 38(7), P. 954 - 998

Published: Aug. 5, 2022

Abstract This review briefly emphasizes the different detection approaches (electrochemical sensors, chemiluminescence, surface‐enhanced Raman scattering), functional nanostructure materials (quantum dots, metal nanoparticles, nanoclusters, magnetic nanomaterials, oxide polymer‐based and carbonaceous nanomaterials) mechanisms. Furthermore, emphasis of this is on integration nanomaterials with optical spectroscopic techniques for identification various biomarkers (nucleic acids, glucose, uric acid, oxytocin, dopamine, ascorbic bilirubin, spermine, serotonin, thiocyanate, Pb 2+ , Cu Hg F − peptides), cancer (mucin 1, prostate specific antigen, carcinoembryonic CA15‐3, human epidermal growth factor receptor 2, C‐reactive protein, interleukin‐6). Analytical characteristics nanomaterials‐based sensors are summarized in tables, providing insights detection. Finally, opportunities challenges analytical (inorganic, organic, biomolecules, peptides proteins) discussed.

Language: Английский

Citations

37
Label‐Free Metal‐Oxide Transistor Biosensors for Metabolite Detection in Human Saliva DOI Creative Commons
Abhinav Sharma, Hendrik Faber, Wejdan S. AlGhamdi

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(27)

Published: Feb. 21, 2024

Metabolites are essential molecules involved in various metabolic processes, and their deficiencies excessive concentrations can trigger significant physiological consequences. The detection of multiple metabolites within a non-invasively collected biofluid could facilitate early prognosis diagnosis severe diseases. Here, metal oxide heterojunction transistor (HJ-TFT) sensor is developed for the label-free, rapid uric acid (UA) 25(OH)Vitamin-D3 (Vit-D3) human saliva. HJ-TFTs utilize solution-processed In

Language: Английский

Citations

7
Electrochemical detection of uric acid in undiluted human saliva using uricase paper integrated electrodes DOI Creative Commons
Seong-Hyun Han, You‐Jung Ha, Eun Ha Kang

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: July 14, 2022

Abstract In this study, we introduce a uricase-immobilized paper (UOx­-paper) integrated electrochemical sensor for detection of uric acid (UA) in saliva. The UOx was immobilized on the zone wax-patterned substrate. This UOx-paper with Prussian blue­-modified, screen-printed carbon electrode after electropolymerization o-phenylenediamine to construct an cell small-volume (20 μL) samples. First, optimized fabrication conditions UOx-paper. Next, amperometric response UOx-paper-based UA analyzed using known concentration standard solution artificial saliva at applied potential − 0.1 V (versus Ag pseudo-reference electrode). UOx-­paper based showed sensitivity 4.9 μA·mM −1 linear range 50 1000 μM (R 2 = 0.998), high selectivity and good reproducibility, as well limit 18.7 (0.31 mg/dL) UA. Finally, quantified levels undiluted samples healthy controls (n 20) gout patients 8). were correlated those measured conventional salivary enzymatic assays serum levels. is user-friendly convenient tool assess

Language: Английский

Citations

25
Surface-Enhanced Raman Analysis of Uric Acid and Hypoxanthine Analysis in Fractionated Bodily Fluids DOI Creative Commons
Furong Tian, Luis Felipe das Chagas e Silva de Carvalho, Alan Casey

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(7), P. 1216 - 1216

Published: March 29, 2023

In recent years, the disease burden of hyperuricemia has been increasing, especially in high-income countries and economically developing world with a Western lifestyle. Abnormal levels uric acid hypoxanthine are associated many diseases, therefore, to demonstrate improved methods detection, three different bodily fluids were analysed using surface-enhanced Raman spectroscopy (SERS) high-performance liquid chromatography (HPLC). Gold nanostar suspensions mixed series dilutions hypoxanthine, 3 kDa centrifugally filtered human blood serum, urine saliva. The results show that gold nanostars enable quantitative detection concentration range 5-50 μg/mL 50-250 ng/mL, respectively. peak areas HPLC maximum intensity SERS have strongly correlated, notably peaks at 1000 640 cm-1, r2 is 0.975 0.959 for Each body number spectral features common hypoxanthine. large overlap bands against spectra 442, 712, 802, 1000, 1086, 1206, 1343, 1436 1560 cm-1. 560, 640, 803, 1290 1620 cm-1 from saliva urine. There no statistical difference between determination (p > 0.05). For clinical applications, centrifugal filtration followed by can be used screening is, which reveal subtle abnormalities enhancing great potential vibrational as an analytical tool. Our work supports hypnosis it possible obtain specific comparing SER signals future, analysis other biofluids employed detect biomarkers diagnosis systemic pathologies.

Language: Английский

Citations

16